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Biomedical subjects

H H Gray

Publications and source records attributed to H H Gray.

49 records · Page 3Linked to original sources
PubMed1985

Intraperitoneal vancomycin and ceftazidime in the treatment of CAPD peritonitis.

The use of intraperitoneal vancomycin and ceftazidime in the treatment of 64 episodes of CAPD peritonitis is reported. Serum and dialysate antibiotic concentrations were measured in 19 of these and the maximum serum vancomycin level recorded was 30 mg/l. Culture of the dialysate was sterile in 52% of the cases, staphylococci were isolated in 30% and the infection rate during 1983 was 2.22 episodes per patient-year. This antibiotic combination has proven safe and effective and easily administered by the patients.

Bacterial Infections↗
PubMed1985

The effect of dietary sodium restriction on leucocyte sodium transport in normotensive subjects and in patients with essential hypertension.

Dietary sodium restriction (10 mmol Na/day) for a period of 2 weeks did not result in any change in the blood pressure of 12 healthy young adults (mean age 21). There was also no change in their leucocyte sodium transport investigated immediately before the diet and on the last day. Sodium restriction (10 mmol Na/day) in 12 middle-aged hypertensive subjects (mean age 56) for the same period of time caused a significant fall in both systolic and diastolic blood pressure. The leucocyte total sodium efflux rate constant was initially low, but after the diet significantly increased towards the control value. The results are compatible with the theory that a circulating sodium transport inhibitor is present in patients with essential hypertension, and is related to salt intake.

Adolescent↗
PubMed1984

Reversal by verapamil of defect in sodium transport in leucocytes in essential hypertension.

The effect of treatment with verapamil on cell sodium transport was studied in the leucocytes of patients with essential hypertension. Previously described abnormalities of sodium efflux rate constant and intracellular sodium content were confirmed, the component of the sodium efflux rate constant sensitive to ouabain being lower and the intracellular sodium content higher in the patients compared with controls. Verapamil reversed these abnormalities and reduced blood pressure.

Adult↗
PubMed1984

Cellular sodium concentration and vasoconstrictor state in hypertension.

The sodium content of peripheral blood leucocytes was estimated in two separate investigations of the relationship between cellular sodium content and the vasoconstrictor state. In the first study various parameters of forearm blood flow were measured in a group of 31 normal subjects. A positive correlation was found between peripheral vascular resistance and leucocyte sodium content (p less than 0.05), and a negative correlation between venous compliance (VV60) and leucocyte sodium content (p less than 0.001). In the second study the leucocyte sodium content of 14 patients with essential hypertension was investigated before and after treatment with the calcium antagonist verapamil. The sodium content was found to be abnormally high, as previously described, and treatment with verapamil was found to reverse the defect. Both studies indicate a link between cell sodium content and the vasoconstrictor state, and the results are discussed in light of current theory.

Adult↗
PubMed1984

Sodium transport by leucocytes and erythrocytes in hypertensive subjects and their normotensive relatives.

Intracellular sodium content and ouabain-sensitive sodium efflux rate constant were measured in leucocytes and erythrocytes from subjects with untreated essential hypertension and also in normotensive subjects with and without a family history of hypertension. Leucocytes from hypertensives were again shown to have a higher intracellular sodium content and lower ouabain-sensitive sodium efflux rate constant than normotensive controls but there were no differences between those normotensive subjects with and those without a family history of hypertension. No differences in erythrocyte sodium content or efflux rate constant were seen between any of the three groups.

Adult↗
PubMedDate not supplied

Late rupture of a superior intercostal artery following repair of aortic coarctation.

Having had surgical repair of aortic coarctation at the age of 12 years, and re-operation at the age of 19 years for stenosis at the site of the previous repair, a 29 years old man presented as an emergency with a 24 hour history of interscapular pain, haemoptysis and collapse. At thoracotomy he was found to have a ruptured superior intercostal artery which was ligated. Spontaneous rupture of an intercostal artery has not been previously recorded.

Adult↗