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Biomedical subjects

H H Goh

Publications and source records attributed to H H Goh.

44 records · Page 3Linked to original sources
PubMed1980

Plasma concentration of steroid hormones after intravenous infusion of testosterone in castrated male transsexuals.

Ten male transsexuals who had surgical operations for sex-reassignment at least three months previously were given intravenous infusion of 2.4 mg (7 subjects) or 12 mg (3 subjects) testosterone over a period of seven hours. In both groups, plasma levels of testosterone and oestradiol measured by radioimmunoassay were significantly elevated one hour after the start of the infusion and remained raised throughout the infusion period. With the lower rate of infusion, plasma levels of testosterone rose from 0.6 ng/ml to 7.4 ng/ml, oestradiol from 16.2 pg/ml to 22.4 pg/ml while levels of androstenedione remained unchanged. When 12 mg testosterone was infused, the level of this hormone was elevated from 0.5 ng/ml to 29.6 ng/ml, while oestradiol increased from 16.5 pg/ml to 45.0 pg/ml. These results indicate that when physiological doses of testosterone are infused, conversion to oestradiol contributes to approximately 13.5% of total circulating oestradiol in men.

Castration↗
PubMed1979

The effect of clomiphene on uncastrated and castrated male transsexuals.

Clomiphene was administered at a daily dose of 100 mg for 5 consecutive days to two groups of male subjects. There were three uncastrated male transsexuals (Group A) and nine castrated male transsexuals (Group B). In the uncastrated subjects Clomiphene enhanced the secretion of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) starting from day 3 of treatment. The magnitude of the increment ranged from 150%--250% over the mean basal plasma level for LH, 113%--262% for FSH and 12%--68% for T. In contrast, Clomiphene suppressed both FSH and LH in the castrated subjects. Equal suppression of both the gonadotrophins were observed. The levels of FSH and LH in plasma on day 3 were suppressed to 66.4% and 66.2% of their respective mean basal levels. Two days after the termination of treatment, suppressions were maintained. These results suggest that Clomiphene acts as an anti-oestrogen in uncastrated male transsexuals and in castrated male transsexuals who have subphysiological levels of oestradiol it acts as a weak oestrogen.

Adult↗
PubMed1979

Testosterone production with hydatidiform moles--in vitro and in vivo studies.

Fresh molar tissues obtained from seven patients were incubated in vitro with dehydroepiandrosterone and androstenedione. The testosterone concentration in molar tissue ranged from 5.4 ng/g wet weight to 43.8 ng/g wet weight. Both precursors were readily converted to testosterone indicating that 17-hydroxysteroid dehydrogenase and 3beta-hydroxysteroid dehydrogenase are present in molar trophoblast. A 50 mg dose of dehydroepiandrosterone was infused into patients with hydatidiform mole before and after uterine evacuation. There was a testosterone peak preceding an oestrogen rise which disappeared after uterine evacuation. It is suggested that the elevated testosterone level in molar pregnancy is mainly due to the conversion of dehydroepiandrosterone in the molar trophoblast.

Androstenedione↗
PubMed1978

Testosterone in the molar vesicle fluid and theca-lutein cyst fluid.

Testosterone was estimated by radioimmunoassay in molar vesicle fluid in 41 patients and theca-lutein cyst fluid in three patients with hydatidiform moles. The testosterone concentration in the molar vesicle fluid ranged from 0.4 ng/ml to 28.1 ng/ml with a mean+/-SEM of 6.0+/-1.0 ng/ml while in the theca-lutein cyst fluid, it ranged from 4.7 ng/ml to 23.5 ng/ml. Oestradiol-17beta and human chorionic gonadotrophin (HCG) were also estimated in the molar vesicle fluid. The oestradiol-17beta concentration ranged from 0.1 ng/ml to 26.2 ng/ml with a mean+/-SEM of 10.7+/-1.1 ng/ml. HCG concentration ranged from 18 000 to 150 000 mIU/ml with a mean+/-SEM of 49 800+/-5 000 mIU/ml. A positive correlation was found between testosterone and oestradiol-17beta (r = +0.37; P less than 0.01) but not between testosterone and HCG (r = 0.32; 0.1 greater than P greater than 0.05). Our findings suggest that molar trophoblast is the major source of testosterone.

Chorionic Gonadotropin↗
PubMed1978

Plasma testosterone in molar pregnancy: Correlation with gestational age, uterine size, theca-lutein cyst and serum HCG.

Plasma testosterone and serum HCG were measured by radioimmunoassay in 46 patients with intact molar pregnancy. There was no significant difference in plasma testosterone between patients with theca-lutein cyst and those without the cyst. This suggests that ovarian contribution to the elevated testosterone in molar pregnancy is probably a minor one. No correlation was found between plasma testosterone and uterine size. However, a positive correlation (r=+0.3567, P less than 0.001) was found between plasma testosterone and the HCG and a rising trend in plasma testosterone was observed with increasing gestation. These results suggest that molar trophoblast is probably the major source of elevated testosterone in the maternal circulation.

Adolescent↗
PubMed1977

Maternal plasma testosterone levels in molar pregnancy.

Plasma testosterone levels in 14 patients with intact molar pregnancy were found to be elevated compared to patients with normal pregnancies of corresponding gestation. The plasma testosterone concentration ranged from 2-0 to 8-4 ng/ml with a mean +/- SE of 5-2 +/- 0-5 ng/ml. After evacuation of the uterus, there was a significant fall in plasma testosterone levels which ranged from 1-6 to 5-9 ng/ml with a mean +/- SE of 3-2 +/-0-3 ng/ml. The trophoblast might have been the source of extra testosterone in molar pregnancy.

Adolescent↗
PubMedDate not supplied

Quantitative comparison of prolactin production by decidua compacta and spongiosa from the first trimester elective termination of pregnancy.

Prolactin (PRL) producing capacity was studied in explants of decidua compacta and decidua spongiosa obtained from 41 patients undergoing termination of pregnancy at gestation 6 to 12 weeks. In vitro PRL producing capacity, expressed as mIU/g protein, of the decidua compacta was significantly higher (P < 0.05) than those of decidua spongiosa. Production of PRL increased with gestation from 6 to 12 weeks with a more rapid rate at the later gestation. The pattern of increase fitted significantly (P < 0.0001) to the exponential model for both decidua compacta and decidua spongiosa. The exponential regression equations for decidua compacta and decidua spongiosa were (ln y = 4.25 + 0.19x) and (ln y = 2.80 + 0.31x) respectively. Hence, although both decidua compacta and decidua spongiosa had a similar pattern of increase in PRL production, the rate of increment was significantly greater in decidua spongiosa than in decidua compacta. These findings suggest that separating decidua compacta and decidua spongiosa of the first trimester would reduce the heterogeneity of decidual tissue and offer a new approach to the studies of the synthesis, release and regulation of PRL production by human decidua.

Abortion, Induced↗