Esophageal motility in tracheoesophageal fistula and esophageal atresia.
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Child↗
Biomedical subjects
H Guyda
Publications and source records attributed to H Guyda.
Hormonal derangements in uremia.
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Calcitonin↗
Circadian rhythms of anterior pituitary hormone secretion: effects of dexamethasone.
Circadian rhythms of hormone secretion are by now well recognized but there are limited data available to compare such rhythms of multiple hormones in individual subjects. Therefore concentrations of serum thyrotropin (TSH), cortisol, growth hormone (GH), triiodothyronine (T3) and prolactin (PRL) were determined in blood samples from six healthy males over periods of 24 hours. A circadian periodicity was identified for cortisol, GH, PRL and TSH; maximum concentrations for TSH and PRL occurred at dissimilar times, namely respectively before and after the GH peak. Maximum TSH coincided with nadir values forplasma cortisol. Dexamethasone administration (3 mg over 36 hours) lowered serum T3 concentration and abolished TSH periodicity without affecting the PRL rhythm. These data suggest that a) nocturnal TSH and PRL maximum levels do not have common mediation; b) there may be an inverse relationship between cortisol and TSH, and c) glucocorticoids at low doses preferentially affect secretion of thyrotropin.
Adult↗
Growth hormone response to apomorphine, a dopamine receptor agonist, in normal aging and in dementia of the Alzheimer type.
The growth hormone (GH) response to the dopamine (DA) receptor agonist, apomorphine HCl (Apo) (0.5 mg SC) was studied in young and elderly normal subjects as well as in patients with dementia of the Alzheimer type (DAT) and controls matched for age, gender and Quetelet index. The GH response was significantly decreased in normal elderly men (mean age 67.3 years; N = 16) compared with young men (mean age 21.2 years; N = 12) and in elderly women (mean age 65.4 years; N = 9) compared with young women (mean age 25.5 years; N = 6) in the luteal phase but not in the early follicular phase. Young men had a significantly greater GH response than young women in either phase of the menstrual cycle. The decline in GH response with normal aging may be related to a decrease in sex steroid activity. There was no significant difference in GH response between DAT patients (N = 15) and paired controls. This suggests that hypothalamic D2 receptor function regulating GH secretion is not altered in DAT.
Adult↗
Somatostatin analogue SMS 201-995 reduces serum IGF-I levels in patients with neoplasms potentially dependent on IGF-I.
Tumors of several organs have been shown to bear cell surface receptors for insulin-like growth factor I (IGF-I), and to exhibit dependence on this mitogen for optimum proliferation both in vivo and in vitro. To investigate the feasibility of a novel form of endocrine therapy that would exploit such dependence, we treated 8 patients with non-endocrine solid tumours with the somatostatin analogue SMS 201-995, in an effort to reduce growth hormone-stimulated IGF-I production. Significant decreases in basal and arginine-stimulated serum growth hormone and serum IGF-I were noted. This approach deserves evaluation as a potentially useful form of palliative endocrine therapy for certain cancers.
Adult↗
[Growth factor activity on cultured chondrocytes (author's transl)].
Somatomedins and vitamin D metabolites have been shown to interact with cartilage metabolism. In the present work their stimulating effect on the growth of rabbit cultured chondrocytes is studied. These cells possess specific binding sites for an insulin like preparation (ILA) distinct from insulin binding sites. They also possess specific nuclear binding sites for one vitamin D metabolite : 24,25- (OH)2D3. In the absence of seric factors, these two types of hormone stimulate the proteoglycan synthesis but do not increase DNA polymerase activities in chondrocytes. Another type of growth factor enhances the cellular multiplication but inhibits the specific protein synthesis (Fibroblast growth factor or Retinal factor). When DNA polymerase activities are induced by fetal calf serum, ILA or vitamin D metabolites may increase the rate of DNA synthesis.
24,25-Dihydroxyvitamin D 3↗