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Biomedical subjects

H Gustafsson

Publications and source records attributed to H Gustafsson.

At least 127 records · Page 7Linked to original sources
PubMed1986

Epidemiology of head injuries in Sweden.

The estimated number and cause of head injuries in Sweden are discussed. Head injuries are common in many activities and the need of head protection is stressed.

Accidents, Occupational↗
PubMed1986

Acute injury statistics--a true picture?

The official data on traffic victims are based on police-reported accidents. Many authors have shown that these data are not fully representative. In order to obtain reliable accident statistics, it is suggested that these be based primarily on injured persons with long-term consequences.

Accidents, Traffic↗
PubMed1985

Ultrastructural morphometry and secretory behavior of acinic cell carcinoma.

Cells from three parotid acinic cell carcinomas were compared stereologically with normal parotid acinar cells. The morphometric studies revealed that the granular volume density was increased in the tumor cells. The cells contained more granules, but the mean granule diameter was considerably less, compared with normal controls. On the other hand, no difference in cell volume or nuclear volume density could be found. Although morphologically similar to normal acinar cells, the tumor cells had a much lower content of amylase. However, in a batch-incubated system, amylase secretion could be elicited with noradrenaline from the tumor cells. Furthermore, noradrenaline stimulation increases tumor tissue cyclic AMP content dramatically. The current study demonstrated the similarity between normal acinar cells and acinic cell tumor cells: the latter respond to physiologic secretion stimuli with an increased tissue level of cyclic AMP accompanied by amylase release.

Amylases↗
PubMed1985

Cytoskeletal proteins in oncocytic tumors of the parotid gland.

Oncocytomas and Warthin's tumors were studied ultrastructurally and with immunofluorescence microscopic techniques against cytokeratins, desmin, vimentin, and actin, the latter characterizing myoepithelial cells. The cell types were found within oncocytomas, one type packed with mitochondria and virtually without filaments, the other contained fewer mitochondria but large amounts of cytokeratins. In Warthin's tumors, all cells contained cytokeratins, the basal cell to a much higher degree. No tumor cells contained vimentin or desmin. Actin was found only close to the apical cell surface in the cylindrical cells in the Warthin's tumors and around the few acinar lumina found in the oncocytomas; thus, a myoepithelial origin of oncocytic tumors of salivary glands seems less plausible. The similarity in staining pattern, namely the pronounced dimorphism of both tumor types, indicates a common progenitor of oncocytomas and the epithelial component in adenolymphomas.

Actins↗
PubMed1985

Characteristics of embryos from repeat breeder and virgin heifers.

The characteristics of 7-day-old embryos non-surgically collected from 35 repeat breeder heifers (RBH) and 24 virgin heifers (VH) were compared by repeated observations within each animal. A higher incidence of the embryos collected from the VH was classified as normal and had reached a more advanced developmental stage than embryos from the RBH. Nearly all VH yielded normal (N) embryos, but morphologically deviated (MD) or degenerated embryos (D) appeared occasionally in many VH. The RBH group contained three subgroups of animals. One group of RBH yielded a high percent of N embryos. A second group yielded mostly MD or D embryos with an occasional N embryo, and the third group only D embryos or no embryos. Heifers from which no embryos were recovered on day 7 yielded uncleaved ova, apparently retarded embryos or no embryos when slaughtered three days after insemination. It is concluded that retarded embryonic development may be a common factor for most RBH. The embryo morphology and the degree of retardation differ among animals and between oestrous periods in the same animal.

Journal Article↗
PubMed1985

Multiple acinic cell carcinoma. Some histological and ultrastructural features of a case.

A case is presented of multiple acinic cell carcinoma, occurring synchronously in the left parotid gland and in the right submaxillary gland of a 75-year-old male patient. Fourteen cases of primary multiple acinic cell carcinoma have previously been reported, all bilateral parotid gland tumours. To our knowledge this is the first report of extraparotid localization of an acinic cell carcinoma in a patient presenting multiple salivary gland tumours. The histologic and ultrastructural characteristics of the tumours are described and a review of the literature is given.

Aged↗
PubMed1985

Embryonic mortality in heifers after artificial insemination and embryo transfer: differences between virgin and repeat breeder heifers.

Embryos were collected from repeat breeder heifers and virgin heifers seven days after insemination, classified and transferred to the uterine horn contralateral to the corpus luteum of synchronised inseminated recipients. Altogether 35 transfers were performed, all reciprocally between repeat breeder heifers and virgin heifers. The recipients were slaughtered either 16 to 17 days or 32 to 35 days after insemination. The survival rate of the native embryos was lower among the repeat breeder heifers than among the virgin heifers both at 16 to 17 days (six of nine vs six of six) and at 32 to 35 days (three of 10 vs seven of 10) after insemination. A higher proportion of embryos transferred from repeat breeder heifers to virgin heifers than from virgin heifers to repeat breeder heifers survived to days 16 to 17 (five of six vs two of nine), while the same proportion of embryos survived to days 32 to 35 (two of 10) in both heifer categories. The results suggest that the uterine environment in repeat breeder heifers is suboptimal for the support of normal embryonic development.

Animals↗
PubMed1983

Ultrastructure of multinuclear giant cells of a human vocal cord Teflon granuloma.

The ultrastructural characteristics of multinuclear foreign-body giant cells (MCG) in a human vocal cord Teflon granuloma are described. The cells were found to contain varying numbers of Teflon particles within their cytoplasm. The particles, rounded or oval in shape, were surrounded by a rather electron-dense membrane. Numerous lysosomal structures were discerned within the cells. The fine structure of MCG in granulomas induced by foreign materials other than Teflon has already been described in man as well as in several experimental animals, and the Teflon MCG resembled these cells in many respects. No evidence of malignant change was found.

Foreign Bodies↗
PubMed1980

Intravesical therapy with adriamycin in patients with superficial bladder tumors.

An 80-mg dose of adriamycin was given intravesically once a month to 58 patients with superficial transitional cell tumor of the bladder. Complete cytological remission was achieved in all 11 patients with previously untreated, flat carcinoma in situ lesions. In 19 carcinoma in situ patients, who were previously treated by other means, cytological remission occurred in 74%. In T1 and T2 papillary tumor remission occurred in 65 and 20%, respectively. Minor local side effects were observed.

Administration, Topical↗
PubMed1980

Estramustine versus conventional estrogenic hormones in the initial treatment of highly or moderately differentiated prostatic carcinoma. A randomized study.

In a prospective randomized multicenter trial patients with highly or moderately differentiated prostatic carcinoma, previously untreated, were allotted either to oral Estramustine phosphate or to intramuscular polyestradiol phosphate plus oral ethinyl estradiol. As regards frequency and duration of tumour remission there was no statistical difference between the two groups. Nor did they differ significantly with respect to adverse reactions. This is an interim report and will be followed later on by a final evaluation.

Bone Neoplasms↗
PubMed1979

Quantitative structural analysis and the secretory behaviour of the rat parotid gland after long and short term isoprenaline treatment.

Isoprenaline (IPR) was administered as daily subcutaneous injections into newborn rats for a period of 9 weeks (long-term treatment) and into 8 week-old rats for 10 days (short-term treatment). Both the parotid and the submandibular glands increased five- to six-fold in weight in the two groups due to hypoertrophy as well as to hyperplasia. The parotid glands were subjected to electron microscopic stereological analyses and to in vitro secretory studies. The results were compared with non-treated controls. Whereas mean total cell volume in the latter was 807 microns 3 it amounted to 5804 microns 3 in glands from long-term IPR-treated rats. A striking increase in size and number of cytoplasmic granules was noted after IPR treatment; there was also a marked decrease in granule electron density as compared with control cells. Granule volume density was 31.2 +/- 1.8% in controls and 58.0 +/- 1.5% in long-term IPR-treated rats. The increase in volume density, however, was accompanied by a relative decrease in amylase and cyclic AMP contents. On a percentage basis, the basal secretion of amylase from incubated IPR-treated parotid glands was markedly higher (roughly twice) than that of control glands; the absolute release of amylase into the medium, however, was only slightly increased. Basal secretion was not energy requiring, which would suggest a passive diffusion. Stimulation by beta-adrenoceptor agonists, including beta 1 and beta 2 selective agents, had no or only a small stimulatory effect in vitro on IPR-treated glands. Dibutyryl cyclic AMP was effective in controls but not in treated glands. Cholinergic stimulation caused a considerable amylase release from glands of IPR-treated rats; this release was comparable to that obtained in controls. The results suggest that superstimulation of the beta-adrenoceptor leads to a decreased sensitivity for adrenergic agonists. This may be due to membrane changes (e.g. modified receptor sites) and/or to an altered intracellular metabolism (e.g. a modified turnover of cyclic nucleotides).

Adrenergic beta-Agonists↗