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Biomedical subjects

H Grosse

Publications and source records attributed to H Grosse.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Positive and negative false diagnosis of cancer detected by autopsy (author's transl)].

1. Among autopsied cases every third case of cancer is only discovered by autopsy or correctly diagnosed with regard to his localization or structure. 2. 90% and more of all cancer of the breast, the skin, the upper alimentary and aerial tract, of the uterus and the vagina and vulva are clinical correctly diagnosed, but only 70% of malignant lymphomas and cancers of the lung, the stomach, the bowel and the ovary. More than 50% of all cancers of the prostata gland, the urinary tract and the pancreas are exactly clinical diagnosed, but the diagnosis of tumours of the brain, the biliary tract and the liver is worse. 3. In about 10% of all clinically diagnosed cancers any cancer does not exist and 10% have another cancer than expected. The clinical and the epidemiological aspect of such cancers is perturbed by these positive false diagnoses. 4. The group of negative false diagnoses descends only from deaths without suspicion for cancer. If cancer cases are more often autopsied than other deaths, the percentage of negatives erroneous diagnoses decreases in spite of the number of unknown unautopsied cancer cases increases. 5. Among the present autopsy rates about 10% (or more) of all cancer cases are not included in medical statistics.

Adult↗
PubMed1979

[Endocarditis in cancer necropsies (author's transl)].

Terminal endocarditis develope in cancer patients almost latently. There is no difference between the so-called "tumor-endocarditis" and other verrucous endocarditis associated with terminal tuberculosis, sepsis or rheumatism. It is more frequent in cases with large or ulcerated primary tumours and multiple metastases than in cases with early cancer. It also develope more frequently in well differentiated cancer (squamous and adenocarcinoma) than in indifferentiated forms of cancer. Terminal endocarditis is often seen in patients with cancer of the gallbladder, pancreas, liver, stomach, rectum, and ovary. In carcinoma of the liver, pancreas and biliary tract the trend to embolism is more reduced through icterus than the trend to terminal endocarditis.

Adult↗
PubMed1979

[Pancreatic neoplasms and risk of thrombosis].

Among all cancers of the pancreas, the liver and the bile ducts with icterus terminal lung embolism ist seldomer then among the same cancers without icterus. The risk of terminal lung embolism is among all tumours of the abdominal region higher than among all tumours of the thorax region, because the compression of the vena cava inferior increases the risk of thrombosis with lung embolism. The prevalence of adenocarcinoma among all cases with lung embolism is caused by the fact, that cancers of the abdomen are more frequent adenocarcinomas then all other tumours.

Adenocarcinoma↗
PubMed1978

[The risk of diabetes after existing cholecystectomy].

No further increase of the risk of diabetes after cholecystectomy is shown in men. In the female sex the number of cases of diabetes may not be decreased by cholecystectomy, in particular, if an obesity occurs after the operation. From this is derived the demand for a normal nutrition after operations of the bile ducts.

Cholecystectomy↗
PubMed1978

[Cancer hazards in females with uterine myoma].

1. Women with uterine fibroids do not have an higher cancer risk than women without fibroids. 2. The carcinome of the breast is the most frequent cancer under autopsy cases with uterine fibroids. The carcinoma of the endometrium and of the pancreas are slightly increases, but tumours of other organs are less frequent. 3. The risk of sarcomatous degeneration of uterine fibroids is with 0,6% about fifty more less frequent then the risk of develope another cancer. 4. Hysterectomy does not diminuish the cancer risk of patients with uterine fibroids: Instead of the (not more possibles) cancers of the genital systems there develope tumours in other organs. 5. Under autopsy cases with uterins fibroids the trend to hypertonia, to adipositas, to myocardical infarction and to embollsm of the lung are slightly increased9

Bile Duct Neoplasms↗
PubMed1977

[Cancer risk in different types of gallstones (author's transl)].

Among 22,868 autopsied adults were 7,411 cases with cholelithiasis or cholecystectomy. In the cancerous gallbladders pigment-stones, pure crystalline cholesterol stones and lobulates stones were seldom found but multiple faceted stones and solitary combined stones are more frequent. If the partial volume of gallstones increased, there were more cases with cholecystitis or later carcinoma. Nevertheless in males with all forms of gallstones, carcinoma of the lung, the stomach, the colon and rectum and the prostatic gland were more frequent then carcinoma of the gallbladder. Only in female with multiple faceted stones and solitary combined stones, carcinoma of the gallbladder was the most frequent cancer. The "Störfeld" of the gallbladder with stones is more important for the localisation of a later carcinoma in female then for men. If the gallbladder with stones should be resected in good time, the patient is protected of the risk of cancer of gallbladder, but the percentage of all cancers among inoperated cases with gallstones is not higher than among cases with previons cholecystectomy. Instead of carcinoma of the gallbladder other cancers develop after cholecystectomy.

Adult↗
PubMed1976

[Comparative studies on the efficiency of ventilation by engström-respirator ER 300 (author's transl)].

The efficiency of ventilation provided by the Engstrom-Respirator ER 300 was examined in 35 patients under general anaesthesia and relaxation during normoventilation and hyperventilation of 15% and 30%. For criteria the acid-base-status of arterial blood was used. There was a tendency to acidosis in all kinds of ventilation, probably as a consequence of surgical effects. During normoventilation the acid-base-status showed changes of low hyperventilation which are desired for security. During hyperventilation of 15% and 30%, arterial pCO2 was reduced to 30 and 27 Torr. Both situations showed no advantage over normoventilation. Using the Engstron-Respirator, normoventilation should be preferred during general anesthesia. Higher degrees of hyperventilation should be avoided because of their effects in lowering cerebral blood flow.

Acid-Base Equilibrium↗
PubMed1975

[Epidemiology of myocardial infarction from the obductor's view].

Fibroses of the myocardium are more frequent in both sexes than acute infarctions. Men and women with microinfarctions or fibroses of the myocardium reach an older age than patients with a macroinfarction. Fresh necroses after infarction (as primary infarction or reinfarction) are less frequent in men than old scars after macroinfarctions, but not in women. With 20-30% the number of the quiescent myocardial infarctions is larger than generally is assumed. Men as well as women with old scars after infarction or with old aneurysms of the cardiac wall do not reach an older age than those with a fresh necrosis after infarction. This is explained by the fact that the chance of survival and also the further life expectancy are more favourable for younger patients with infarction than for older ones.

Age Factors↗
PubMed1975

[Haemodilution and cerebral blood flow (author's transl)].

Cerebral blood flow has been estimated in 10 patients during acute haemodilution and during the consecutive operation. Cerebral blood flow showed a lasting increase during the time of haemodilution, but this increase did not parallel the decrease of haematocrit value. The increase of cerebral blood flow became pronounced only, when the haematocrit become lower than 30%. Assumably the elevation of cerebral flow is mainly due to autoregulative mechanisms of cerebral blood flow to sustain oxygenation. It is concluded, that haemodilution below values of 30% hc might be dangerous in patients suffering from cerebral sclerosis.

Blood Gas Analysis↗
PubMed1975

[Use and limitations of acute normovolemic hemodilution].

Acute normovolemic hemodilution was performed in 46 pts. before major surgical procedures 1800 ml of pt's blood were withdrawn and hct. lowered to 24.8% mean. The hct. after retransfusion averaged 31.8% while homologous blood could widely be avoided. 78% of pts tolerated a.n.h. well or sufficiently. During a.n.h. circulatory parameters remained constant while CO rose from 4.4 to 6.1 1/min. Shortly after a.n.h., in 13 cases slight, in 10 cases, however, severe side reactions occurred: rise in BP, HR and PAP, peripheral vasoconstriction with decrease of peripheral blood flow, unproportional increase of CO and ST-depression in ECG. As a reason of this centralisation reaction a sympathetic reaction and hypoxia are discussed.

Adult↗
PubMed1975

[Blood gas studies on the efficiency of the ventilator "Pulmomat" (author's transl)].

Efficiency of ventilation of Pulmomat has been examined in 48 patients under general anaesthesia and relaxation during normoventilation and hyperventilation of 15 and 30% degree. For criteria the acid-base status of arterial blood has been used. In normoventilation acid-base status remained unchanged within the normal range providing a regular control respectively correction of ventilationvolumes. There was no significant difference between results of 15 and 30% hyperventilation. In both situations arterial pCO-2 was reduced 15-20%. There was a tendency to acidosis in all kinds of ventilation presumably as a consequence of surgical effects. For security using the Pulmomat as respirator, a hyperventilation of 15% degree is recommanded in clinical use.

Acid-Base Equilibrium↗