Search PubMed⌕ Search

Biomedical subjects

H Gomi

Publications and source records attributed to H Gomi.

At least 91 records · Page 5Linked to original sources
PubMed1986

Direct expression of urogastrone gene in Escherichia coli.

Human epidermal growth factor (urogastrone; UG) is a 53-amino acid polypeptide hormone. A 192-bp DNA fragment containing the coding sequence for methionyl UG (Met-UG) and the ribosome-binding site (RBS) was chemically synthesized and placed downstream from the promotor for the Escherichia coli outer-membrane lipoprotein gene (lpp) on a plasmid. E. coli cells harboring the plasmid directed the synthesis of Met-UG at 10(2)-10(3) molecules per cell. Next, the coding sequence for Met-UG was inserted in a runaway-replication plasmid and expressed under the control of the lpp promoter and the RBS derived from bacteriophage Mu cII gene. Upon heat induction, the cells harboring the recombinant plasmid synthesized 10(5) molecules of Met-UG per cell.

Amino Acid Sequence↗
PubMed1986

[Results of radiation therapy of nasopharyngeal cancer].

The results of irradiation therapy for nasopharyngeal carcinoma in 49 patients treated at the Department of Radiology, Jikei University of Medicine, between 1968 and 1981 are reviewed. The CR rate increased in proportion to increased dosage, especially in well-differentiated squamous cell carcinoma. The five-year cumulative survival rate was 40% in all stages. Severe late radiation injury occurred in two patients.

Adolescent↗
PubMed1986

[Interstitial radiotherapy for recurrent cancer of the uterine cervix].

Thirty-seven patients with recurrent cancer of the uterine cervix were treated with interstitial radiotherapy between 1966 and 1983 at NIRS. The 1-, 3- and 5-year survival rates after the salvage treatment were 57%, 30% and 24%, respectively. A local control rate of more than 80% was achieved in smaller-than-thumb-sized lesions. However, the rates decreased to 27% in larger tumors. The local control rate of all patients was 58%. A dosage of 60-70 Gy was required to control the smaller lesions, while the larger ones were difficult to control irrespective of the dosage. Therefore, early detection of recurrent cancer is most important for this treatment.

Brachytherapy↗
PubMed1986

[Radiation therapy of carcinoma of the vulva].

Thirty-three patients suffering from squamous cell carcinoma of the vulva were treated with radiation therapy alone between 1961 and 1980 at the NIRS. The five-year survival rate and local control rate in each stage were 91% and 36% in T2 and 71% and 64% in T3, respectively. These results indicated that the early detection of recurrent tumor by close follow-up and an adequate retreatment procedure is very important for prolonging survival. Late recurrence, more than five years after treatment, appeared in 30% of the patients and this may be one of the special figures of postirradiated vulval carcinoma. The primary site was irradiated with external electron beams or radium needles, and better results were obtained with the later. Irradiation to the lymph node area in the pelvic cavity was necessary in patients with a more advanced stage of disease than T2.

Adult↗
PubMed1986

[An analysis of prognostic factors in radiotherapy of carcinoma of the uterine cervix].

An analysis of prognostic factors for stage 3 carcinoma of the uterine cervix was performed using multivariate analysis. Such factors were closely related to prognosis of the patients as follows; 1) risen temperature during the treatment, kidney function before treatment and age which were concerned in local recurrence 2) risen temperature, leucocytosis, hypertension and kidney function which were concerned in distant metastasis. Since the patients have various factors which have correlation between one another, it is important to investigate each factors separately more detail aspect.

Aged↗
PubMed1985

Expression of a synthetic human growth hormone gene in yeast.

A synthetic human growth hormone (hGH) gene was efficiently expressed under the control of the repressible acid phosphatase promoter in yeast (Saccharomyces cerevisiae). More than 10(6) molecules of hormone were formed per cell despite the fact that the gene was constructed with codon preference for Escherichia coli.

Alkaline Phosphatase↗
PubMed1985

[Fast neutron radiotherapy at NIRS, indication and prospects].

Eleven hundred and seventy one patients, 921 previously untreated and 250 recurrent, have been treated with 30 MeV (d-Be) fast neutron beam between 1975 and 1984 at NIRS. Some trends have been identified: non-randomized results have been at least as good as those of photons in carcinomas such as: supraglottic carcinoma in the larynx, pancoast type tumor of the lung, malignant melanoma of the skin and so on. Randomized results with mixed beam studies for carcinoma of the uterine cervix have indicated no significant advantages against those of photons. Treatment technique for the beam concentration must be improved to demonstrate the merit of neutrons in the next step.

Adult↗
PubMed1981

Standard blood pressure curves of schoolboys and schoolgirls in Akita prefecture.

Blood pressure of 251,742 schoolboys and schoolgirls aged 7 to 18 years was measured in the year 1970. Analyzing these data, the authors obtained the percentile values classified by age. The lowest hypertensive systolic blood pressures, which are represented by the 95th percentile, are 123, 126, 128, 128, 129, 134, 138, 144, 149, 152, 155, and 154 mmHg in boys from 7 to 18 years of age, respectively. The corresponding values are 123, 126, 128, 130, 134, 138, 139, 143, 144, 142, 142, 141 mmHg in girls of the same ages. Girls' systolic blood pressure is higher than that of boys between the ages of 10 and 13 years. After the 14th year of age, girls' systolic blood pressure does not increase any further, whereas boy's blood pressure continuously increases until 18 years. The present results differ in the following two points from the study in USA (1977): 1) The uniform rise of blood pressure with age is not observed. 2) Blood pressure, especially systolic pressure, is higher in girls than in boys between the ages of 10 and 13 years, although it is higher in boys thereafter until 18 years.

Adolescent↗