Biomedical subjects
Publications and source records attributed to H Goldstein.
A new class of statistical models is proposed for the analysis of longitudinal data, especially those from growth studies. The models are all derived from a simple univariate two-level polynomial model. It is shown that they make efficient use of available data, and can handle a very wide range of problems. They have several important advantages over existing procedures.
A new method for estimating age-related centile curves has been developed, which is suitable for measurement covering a wide age range. The method was used to calculate weight centile curves of 8995 children from birth to 6 years obtained by the Collaborating Centre for Physical Growth and Psychosocial Development of Children in Shanghai, China.
A new statistical model is proposed for the analysis of hierarchically structured cross-sectional growth data, especially for where measurements are made over long age ranges. The model combines a two-level model with grafted piecewise polynomials, to make efficient use of available data.
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In an open-label, multicenter study, the efficacy and safety of gadopentetate dimeglumine (0.1 mmol/kg) administered IV as an MR imaging contrast agent were evaluated in 113 patients with symptoms of spinal tumors. The examinations were performed with a variety of imagers at different field strengths. Scans with short and long TRs were obtained in all patients before and after IV administration of the contrast medium. Contrast enhancement was seen in 77% of patients. No enhancement was seen in 23%, but this absence was useful diagnostic information in all cases. In 66% of the cases, additional information regarding location, size, configuration, and/or characterization of the lesion was obtained from postcontrast scans. The investigators made a change from referral diagnosis to postinjection diagnosis in 30% of the cases. Postinjection images provided additional information in 96% (43/45) of intradural extramedullary and intramedullary tumors; it also provided additional information in 20 (53%) of 38 cases of extradural tumor. Gadopentetate dimeglumine demonstrated a high level of safety and tolerance, as evidenced by the lack of clinically significant trends toward abnormal changes from baseline evaluations for physical and neurologic examinations, vital signs, and hematologic and blood chemistry parameters and by the low prevalence and mild nature of adverse reactions. Gadopentetate dimeglumine was found to be efficacious in the evaluation of suspected spinal tumors. High levels of safety and tolerance were demonstrated.
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