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Biomedical subjects

H Gofferje

Publications and source records attributed to H Gofferje.

35 records · Page 2Linked to original sources
PubMed1977

[The behavior of prealbumin, retinol binding protein and the immunoglobulins during 3 weeks of nutritional rehabilitation].

A significant improvement in the protein status of twelve malnourished geriatric patients was achieved during a three-week daily supplementation of the hospital diet by 9 g essential amino acids (eight classical essential amino acids plus histidine). This was especially evident in the doubled serum concentration of prealbumin and retinol-binding protein. The changes of total serum protein and hemoglobin were much less distinct. The immunoglobulins IgA, IgM and IgG remained unchanged for the entire observation period.

Amino Acids, Essential↗
PubMed1977

[The geriatric patient and his nutrition].

The nutrition of geriatric patients should observe the following characteristics of advanced age: diminished calorie requirement, impaired glucose tolerance, tendency to elevated serum cholesterin and triglyceride levels, increased requirements for protein of high biological value, absence of thirst and reduced total body water. Considering these metabolic changes recommendations for an adequate nutrition of senescent people are discussed.

Adult↗
PubMed1977

[Blood proteins during short-term fasting and during supply of essential amino acids].

A most significant decrease of prealbumin and retinol-binding protein was observed in the serum during an absolute alimentary abstinence for five days, whereas the immunoglobulins IgG, IgA and IgM were not influenced. The decrease in the concentration of prealbumin and retinol-binding protein was significantly diminished through a minimum diet of 15 g essential aminoacids and 60 g carbohydrates. Both proteins form a complex in a mole ratio of 1:1. Based on the four to five times higher prealbumin concentration, we recommend this parameter for the routine observation of protein metabolism during weight reduction.

Administration, Oral↗
PubMed1977

[Hyperamylasemia following infusion of hydroxyethyl starch with different molecular weight distributions].

The infusion of hydroxyethyl-starch leads to hyperamylasemia due to the complex structural interrelation of the amylase molecules in the serum and the hydroxyethyl-starch molecules. The amylase clearance is reduced because glomerular filtration of the macromolecules thus formed is not possible. The extent of hyperamylasemia is dependent on the intravascular remission duration of the hydroxyethyl-starch preparation used. The question, whether and to what extent an enzyme induction in the liver also contributes to the observed hyperamylasemia, remains open.

Alkaline Phosphatase↗
PubMed1975

[Osmo-oncotherapy in brain edema].

The treatment of cerebral edema must be directed towards improving the volume regulation of the brain cell which is disturbed due to reduced blood flow and hypoxia and towards restoring the disturbed function of the blood-brain barrier. Onco-osmotherapy increases the effective intracranial blood pressure difference and improves cerebral blood supply and oxygen absorption, thus exerting a positive effect on sodium concentration in the brain cell which is responsible for the intracellular corticocerebral edema. After renal excretion of the osmotherapeutic agent, however, water may again flow into the brain cell, depending on the osmotic gradient. When the function of the blood-brain barrier is disturbed, osmotherapy may lead to an undesired increase of the osmotic pressure in the tissue. In spite of this, onco-osmotherapy is one of the most effective measures in the treatment of cerebral edema. Choice of therapeutic agents, dosage, infusion rates, side effects and contraindications are dealt with in detail.

Biological Transport↗
PubMed1975

[Acid-base equilibrium- -disorders and therapy].

The purpose of this work is to give a brief resume, with figures and tables, of the knowledge concerning the acid-base balance which is indispensable in intensive therapy. The effects of disturbances of the acid-base balance on organic functions are shown and, therefore, the importance of a situation-adapted therapy is particularly stressed. In this connection, the role of infusion therapy in the treatment of disturbances of the acid-base balance is especially discussed.

Acid-Base Equilibrium↗
PubMedDate not supplied

[Malnutrition in old age - diagnosis and therapy].

The nutritional state of 309 geriatric patients in a medical clinic was determined with the following parameters: Weight/height index, triceps skin fold, arm muscle circumference, creatinine/height index, albumins, prealbumin, transferrin and cholinesterase. Using these parameters we found that 54,4% of these patients were suffering from malnutrition (27,8% marasmus, 9,4% kwashiorkor-like syndrome, 17,2% marasmic kwashiorkor). Triceps skin fold, arm muscle circumference and creatinine/height index were the most precise parameters to confirm marasmus. Prealbumin and cholinesterase are especially recommended to determine acute protein deficiency, albumin to confirm chronic protein deficiency. It was also possible to demonstrate the deleterious effect of malnutrition on the immunological system of the patient through determination of the absolute lymphocyte count in peripheral blood and intracutaneous testing with streptokinase-dornase, mumps skin test antigen and candida vaccine.

Aged↗