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Biomedical subjects

H Gleispach

Publications and source records attributed to H Gleispach.

At least 55 records · Page 3Linked to original sources
PubMed1982

Changes in blood catecholamines, insulin, corticosterone and glucose during the course of the Sephadex inflammation.

During an acute inflammation, the blood levels of noradrenaline, dopamine and insulin increase uniformly until the fourth day, then reach a climax which for dopamine is above the norm, while the suppressed levels of noradrenaline and insulin approach the norm. All values decrease on the fifth day (end of the experiment). Glucose behaves inversely, showing a minimum on the fourth day. Corticosterone displays two peaks, on the first and fourth days. The adrenaline level differs distinctly from these patterns: it is elevated on the second, fourth and fifth days. By releasing each catecholamine independently, the organism can possibly influence the course of the inflammation.

Animals↗
PubMed1981

[The metabolism of hydrocortisone, prednisolone and fluocortolone (author's transl)].

The plasma levels of hydrocortisone, prednisolone and fluocortolone were studied in healthy males by a competitive protein-binding technique after separation by thin-layer chromatography. Cortisone showed a mean morning level of 440 nmol/l +/- 165 nmol/l and a half life of 4.8 hours. The half life of prednisolone was determined after intravenous injection of 25 mg and found to be 2.4 hours and that of fluocortolone, after oral administration of 60 mg, was calculated to be 1.7 hours.

Adolescent↗
PubMed1981

[Urinary testosterone excretion in boys in relation to other parameters of somatic maturity (a longitudinal study) (author's transl)].

The dependence of urinary testosterone excretion on age was studied in healthy male volunteers. Furthermore, it was determined monthly over 2 years in 20 boys aged 10 to 12 years. The values obtained for urinary testosterone were compared with the parameters of somatic growth like bone age, height, weight and testicular volume. The greatest intraindividual changes in testosterone excretion were found during puberty, and also a great interindividual difference in the onset of puberty. A relatively good correlation was obtained for the mean testosterone excretion and the bone age, on the one hand, and the testicular volume of a boy on the other hand.

Adolescent↗
PubMed1981

[Valproic acid -- clinical efficiency and serum concentration in the treatment of petit mal epilepsy in childhood (author's transl)].

28 children with Petit mal epilepsy were treated with valproic acid either as drug of primary choice or because of resistance to other antiepileptic drugs. Efficacy of treatment was measured by reduction of seizure frequency and EEG-recordings. Serum concentration of valproic acid was measured in all patients. The best clinical efficacy was found in children with absence seizures, who also required the lowest dosages. Side effects of therapy were (in most cases) transitory.

Child↗
PubMed1979

Tumor host relations. I. Increased plasma cortisol in tumor-bearing humans compared with patients with benign surgical diseases.

Plasma cortisol was measured by a protein binding technique in 81 patients with malignant tumors of different extent and various sites and in 82 patients with benign surgical diseases. The mean value of the tumor patients (x +/- s = 165 +/- 69 micrograms cortisol/l plasma) was increased significantly compared with the benign surgical disorders (100 +/- 45 micrograms/l). Within the group of patients with benign surgical disorders there was little variation by the type of disease (cortisol mean values given in brackets): benign breast tumors (95), gall stones (107), ulcer of the stomach and duodenum (96), hernia (78), appendicitis acuta (112), and struma (90). The results are in accordance with the hypothesis that glucocorticoids are involved in the increased protein catabolism of skeletal muscles and other signs of cachectic tumor patients.

Adolescent↗
PubMed1979

Changes of serum testosterone and of LH-RH test after treatment of cryptorchidism by intranasal LH-RH.

The aim of the present investigation was to study, in a collaborative double-blind study, the treatment with intranasal LH-RH application of boys aged 1 1/2 to 12 years, who suffered from unilateral or bilateral cryptorchidism. A total of 88 subjects were randomly and blindly allocated to LH-RH and placebo therapy. Before and after 4 weeks of treatment basal testosterone serum levels were estimated and LH-RH tests were performed. Intranasal treatment with LH-RH resulted in partial or complete descents of testes in 23 out of 88 patients, whereas the position of testes remained unchanged in 17 subjects. 42 boys did not respond to placebo therapy, but complete descents were observed in 6 boys of the placebo group. Hormone analysis data of 4 different laboratories were recorded and statistically evaluated. No changes of LH, FSH and testosterone were found in the placebo groups. Only patients of the Frankfurt group responded to LH-RH test with augmented LH release after therapy (P less than 0.05). All patients treated with intranasal LH-RH showed a significant decrease of FSH release after therapy (P less than 0.05 to P less than 0.01). Basal testosterone serum levels were found to be increased after therapy only in the patients treated at Zürich (P less than 0.05). Data of the present study combine to suggest that chronic application of LH-RH may result in an overstimulation phenomenon, and that LH-RH test as well as basal testosterone levels cannot be used as prognostic index of therapy efficacy.

Administration, Intranasal↗
PubMed1977

Digoxin elimination by exchange transfusion.

The report covers four cases presenting simultaneous indications for digitalisation and exchange transfusions. Intravenous administration of digoxin was followed: 1. by monitoring of the behaviour of the plasma digoxin level; 2. by determination of the total amount of glycoside eliminated by the blood exchange. Particular attention was paid to the effect of the delay between injection and exchange transfusion on the amount of digoxin eliminated. All four cases showed moderate falls in plasma levels. The amounts of digoxin eliminated by exchange transfusion were in reverse relationship to the delay between administration of digoxin and the blood exchange. At no time did the eliminated fraction exceed 5% of the total amount present in the body.

Child, Preschool↗
PubMed1977

[Binding of cortisol, fluocortolone and difluocortolone to human plasma proteins (author's transl)].

The binding properties of [3H]cortisol, [3H]fluocortolone and [3H]difluocortolone by human plasma, human albumin, human- beta- and gamma-globulins have been studied by equilibrium dialysis. Cortisol, in physiological concentrations (0,4 micromol/l), is 98% bound in human plasma at 25 degrees C, fluocortolone 96% and diflucortolone 85%. Uncer physiological conditions cortisol is mainly bound to the corticosteroid binding globulin (transcortin). 2/3 of fluocortolone is bound to transcortin and 1/3 to albumin and globulins, whereas difluocortolone is mainly bound to albumin and to globulins but not to transcortin. The binding affinities of beta- and gamma-globulins are -ery low for the corticoids investigated, but they are higher for fluocortolone and difluocortolone than for cortisol.

Carrier Proteins↗
PubMed1976

[Results with the Clinicard analyser in a paediatric hospital (author's transl)].

The most important chemical pathological investigations which require to be undertaken in the emergency laboratory of a paediatric hospital are of the serum electrolytes, blood glucose, cerebrospinal fluid glucose, blood urea nitrogen, total proteins, bilirubin and calcium. It is imperative to have the opportunity of controlling these parameters both during the day and night. In order to be independent of the presence of a technician we were interested in finding an instrument which can be used by untrained personnel and gives results of sufficient accuracy. Hence, the clinicard analyser was tested in regard to reproducibility and accuracy of results when used by highly-trained technicians and by persons without knowledge of laboratory work. It was established that the values obtained by these two groups are similar and sufficiently reproducible for emergency use. The accuracy of the instrument was tested with 2 charges of cuvettes and with different control sera. In the case of total proteins differences were found between the different control sera used. The values obtained for blood urea nitrogen and for blood glucose lay within the range given for Labtrol and for Seronorm. The accuracy of bilirubin was tested with 5 different control sera and all values lay within the ranged given by the factory. Calcium was tested with Labtrol and Fluinorm and also with sera and urines from different patients. The values were within the range given for the test sera and were comparable to those measured with the calcium analyser of EEL, but were about 7% lower than those determined using atomic absorption. The values obtained for cerebrospinal fluid glucose correlated well with those obtained by the routine method.

Adolescent↗
PubMed1975

[Rudimentary uterus in testicular feminization (author's transl)].

The absence of uterus has been regarded by a number of authors as a condition for the diagnosis of testicular feminization, although cases with a rudimentary uterus have been reported. However, their number within the framework of this syndrome cannot be exactly determined. In the present report on a 22 year-old patient with testicular feminization and uterus bicornis solidus a double uterus malformation identical with that described in the Mayer-Rokitansky-küster syndrome was found. Forms of testicular feminization with rudimentary uterus in genetically-male individuals may be explained by the absence of androgens, or the absence of reactivity on the part of the target organ, and a simultaneous disturbance (lessening) of the function of the so-called X-factor (oviduct repressor) during early embryonal development. Our own observations, as well as reports in the literature, suggest a theory according to which testicular feminization may be regarded as a series of morphological variants, from male-oriented forms with vaginal aplasie, hypertrophy of the clitoris and male distribution of pubic hair, to female-orientated ones with a vagina of normal length and a rudimentary uterus. The absence of a uterus as a condition for the definition of the syndrome can be maintained only so far as no cases have, as yet been observed with a normally-developed uterus in a typical position. The karyogram showed a small Y-chromosome. Functional anomalies may only be surmised, since Y-anomalies are frequent (3% in a random collection). The morphology of the testes mirrored the functional embryonal insufficiency (pre-pubertal, undifferentiated testicular tissue with a varying amount of stroma and Leydig cells); the basal excretion of testosterone, 17-ketosteroid fractions and pregnane in the 24-hour urine was within the normal range for males. Oestrogen production over and above the "adrenal values" was also present. The values for plasma testosterone, which are in accordance with those of males of a similar age, are considered as indicating the importance of "androgen resistance in the periphery" as a factor in the aetiology of testicular feminization.

17-Ketosteroids↗