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Biomedical subjects

H Gershon

Publications and source records attributed to H Gershon.

At least 91 records · Page 5Linked to original sources
PubMed1972

Antifungal activity of 5-, 7-, and 5,7-substituted 2-methyl-8-quinolinols.

2-Methyl-8-quinolinol and sixteen 5-, 7-, and 5,7-substituted derivatives with fluoro, chloro, bromo, iodo, nitro, and amino substituents were tested for in vitro antifungal activity against five fungi, Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes. The 5,7-dichloro and 5,7-dibromo derivatives were the most fungitoxic of the compounds tested. With the exception of these two compounds and 5-iodo-2-methyl-8-quinolinol, the 2-methyl analogues were less active than the corresponding 8-quinolinols.

Antifungal Agents↗
PubMed1971

Antifungal activity of substituted nitrobenzenes and anilines.

Series of 1,3-dihalogeno-5-nitrobenzenes, 3- and 3,5-halogenoanilines, and 2,6-dihalogeno-4-nitroanilines were tested for fungitoxicity against Aspergillus niger, A. oryzae, Trichoderma viride, Myrothecium verrucaria, and Trichophyton mentagrophytes in shaken culture by using Sabouraud dextrose broth enriched with yeast extract as the test medium. 1,3-Dichloro-5-nitrobenzene, 1,3-dibromo-5-nitrobenzene, 3-iodoaniline, 3,5-dichloroaniline, and 3,5-dibromoaniline were found to possess sufficient activity, compared with 8-quinolinol, to warrant further study.

Aniline Compounds↗
PubMed1968

Studies on the competence of single cells to produce antibodies of two specificities.

Two series of experiments were performed, utilizing a modification of the hemolysin plaque technique which registers 19S antibody, in an attempt to determine the frequency of cells capable of simultaneously producing antibody to two non-cross-reacting antigens. Mice were immunized i.v. with rabbit and camel RBC and their spleens assayed for cells producing antibody against both antigens. 16,904 cells producing antibody of one or the other specificity, from 26 mice, were counted. Not one cell was detected which produced antibody of two specificities. Rabbits were immunized intradermally with HSA to which polyalanyl and p-azobenzenearsonate groups were chemically attached. The individual haptens, polyalanyl, and p-azobenzenearsonate groups were coupled to separate aliquots of SRBC, and the lymph nodes of immunized rabbits were assayed for cells releasing antibody against both haptens. In a study of 11 rabbits, after counting 27,845 cells producing antibody, we detected no "double" plaques.

Animals↗