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Biomedical subjects

H Gastpar

Publications and source records attributed to H Gastpar.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Endolaryngeal surgery using highly concentrated human fibrinogen as tissue adhesive. Further trials with fibrin glue].

The use of an activated human fibrinogen concentrate in endolaryngeal surgery has been performed in 31 cases without the conventional suturing technique. Among the satisfactory results of fibrin gluing in endolaryngeal regions are optimum healing tendency due to haemostasis, lack of tissue irritation and toxicity. Persistence and highly adhesive properties were studied in experimental investigations in the dog following motoric stress of clot-sutured vocal cords.

Adult↗
PubMed1979

Studies on vasoocclusive crisis of sickle cell disease. I. Effect of pentoxifylline.

A method was developed to induce and continuously monitor vasoocclusive crisis of sickle cell disease in non-human primates. Pentoxifylline, a phosphodiesterase inhibitory agent, showed significant preventive effect. This may be based on its ability to increase intracellular cAMP levels and consequently to decrease platelet aggregation and to increase red cell deformability.

Anemia, Sickle Cell↗
PubMed1979

[Clinical experiences with a human fibrin adhesive in head and neck surgery (author's transl)].

Clinical experiences in a timespan of two and a half years with a human fibrinogen concentrate in head and neck surgery are reported. In 49 patients with different bleeding disorders tonsillectomies, adenectomies and nasal dermoplasties (Osler's disease) were carried out. In these cases primary hemostasis due to the fibrin adhesive combined with an allogenic collagen implant could be obtained without any subsitution of the deficient blood clotting factors. In all these cases no complications could be observed. In other 193 cases which underwent a surgical treatment in the head and neck region (frontobasal and laterobasal fractures, rupture of the carotid artery, closure of perforations of the nasal septum and oroantral fistulas, different methods of skinmucosa- and nerve-grafting) the fibrin adhesive was successfully used.

Carotid Artery Diseases↗
PubMed1978

[Inhibition of cancer cell stickiness, a model for the testing of in vivo thrombocyte aggregation inhibitors. IV. Effect of sulfinpyrazone].

It has been shown that sulfinpyrazone is able to interfere with the dynamic interaction between sticky Walker-256-carcinosarcoma cells and the vascular endothelium. This effect is due to a dose-dependent inhibition of platelet adhesiveness and aggregation to sticky circulating tumor cells and their consequent attachment to the vascular endothelium as observed by means of intravital capillary microscopy in the mesentery of rats. Further proof of these investigations was that sulfinpyrazone led to a dose-dependent inhibition of the immediate drop of circulating platelets and reduced significantly the lethal pulmonary tumor cell embolism which occurred in 57.5% of the controls within 5-10 minutes after intravenous transplantation of 1 X 10(6) Walker-256-carcinosarcoma cells. These results are interpreted in an inhibition of platelet adhesiveness and aggregation in vivo by sulfinpyrazone.

Animals↗
PubMed1977

[Tonsillectomy in patients with bleeding disorders].

When injury of a major vessel can be ruled out as the cause of bleeding after tonsillectomy, a discrete disturbance of hemostasis must be considered. These are mainly slight thrombopathies or a pathologically increased fibrinolysis, which were not detected by routine tests and the past history. In former times severe bleeding disorders were a strict contra-indication for tonsillectomy. Under the supposition of an exact coagulogram and the substitution of highly purified factor concentrates the risk of severe post-tonsillectomy hemorrhages in such patients today is nearly the same as in patients with a normal hemostase.

Antifibrinolytic Agents↗
PubMed1977

Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis.

The mechanism of the early stage of metastasis formation by sticky blood-born cancer cells is discussed. Abnormal platelet aggregation to circulating and lodged cancer cells, as well as alterations of blood coagulation and fibrinolysis play an important role. The reducing effect of several platelet aggregation inhibitors on cancer cell stickiness and tumor embolism mortality has been investigated in rats after intravenous transplantation of 1 X 10(6) Walker-256 carcinosarcoma cells. The tested substances diminished platelet aggregation to circulating cancer cells, leading to a dose-dependent inhibition of cancer cell lodgment to the endothelium. Furthermore, some of the substances prevented lethal pulmonary tumor cell embolism which was observed in 60% of the controls. These results are interpreted by assuming an inhibition of disseminated intravascular coagulation which occured after intravenous transplantation of Walker-256 carcinosarcoma. On this basis a clinical long-term study for metastasis prophylaxis was started more than 4 years ago with one of the tested substances, the dipyridamole derivative RA 233, in 40 patients with sarcoma or malignant lymphoma of the head and neck region. The provisional results obtained in matched pairs are discussed.

Animals↗