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Biomedical subjects

H Garzuzi

Publications and source records attributed to H Garzuzi.

3 recordsLinked to original sources

[Mucormycosis].

Mucormycosis, which is caused by a group of fungi found in rotting fruit and vegetables, can be fatal. The fungi do not cause disease in healthy individuals, but attack those with immunodepression. The usual patient is a diabetic in ketoacidosis, but also those with other causes of metabolic acidosis, such as AIDS, burns, and gastrointestinal tract ulcers, may be affected. When the disease results in infection of the sinuses, the patient may present with orbital apex syndrome: exophthalmos, IInd, IIIrd, IVth and VIth nerve involvement, conjunctival chemosis and central artery or vein occlusion. The presence of necrotic tissue in the nose should alert the physician to the possibility of mucormycosis. Prognosis is poor if it spreads to the brain or cavernous sinus and if treatment does not include surgery. We present 3 typical cases: a 71-year-old women and men aged 62 and 73, respectively. The first 2 died soon after the diagnosis was established. They had been conservatively treated and the disease had spread to the brain. The third survived after several months of treatment which included surgical debridement.

Aged↗

Cone-rod dysfunction in patients with unexplained reduction in visual acuity.

Electrophysiologic tests were performed in 233 patients who complained of reduced visual acuity with no satisfactory clinical explanation. The functional integrity of the retina was assessed from the light- and dark-adapted electroretinogram. Macular function and conduction in the optic nerves were estimated from the flash visual evoked potentials. Of the 233 patients 78 were grouped together on the basis of the electrophysiologic and clinical findings. They were characterized by subnormal electroretinogram responses with the cone system more affected than the rod system. The flash visual evoked potential responses were of abnormal waveform and prolonged implicit times. Most of these patients exhibited normal fundi. The reduction in visual acuity, the degree of electroretinogram deficits and the pattern of the visual evoked potential responses were similar in both eyes of each patient, indicating a symmetric disorder. Slight deterioration of visual acuity and electrophysiologic variables were observed in 37 of the patients who were followed up over a period of up to 8 years. The electrophysiologic findings indicate that about 20% of patients complaining of unexplained reduction in visual acuity were suffering from a diffuse retinal disorder affecting the peripheral retina as well as the macular region. On the basis of electrophysiologic findings and clinical symptoms, we suggest grouping these patients under a new entity: cone-rod dysfunction.

Adaptation, Ocular↗