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Biomedical subjects

H G Wolf

Publications and source records attributed to H G Wolf.

At least 19 recordsLinked to original sources
PubMed2004

[Assessment and outcome of perinatal and neonatal care in North Rhine area].

The objective of the quality assurance program "Perinatalerhebung" and "Neonatalerhebung" is to ameliorate the perinatal and neonatal care in German hospitals. Standardised data defined by a team of experts in the early seventies are documented for more than 20 years in the North Rhine area. The documentation of more than 1.6 million deliveries created a data pool that served as a thesaurus for the improvement of medical care in obstetrical units. The same has been achieved for neonatal care on the documentation basis of more than 168,000 newborn infants admitted to a neonatal department. The results show that the approach to evaluate continuously the data monitored enables improvement in care. The support given is the anonymous collection of the documentation sheets/data sets and their evaluation by an expert committee. The results show that obstetrical management changed and the measurable results improved demonstrably. The efforts seem to be worthwhile in view of the fact that less than 1 % of the total cost of care has been spent for this project.

Female↗
PubMed1997

Pregnancy outcomes in mothers with pregestational diabetes: a population-based study in North Rhine (Germany) from 1988 to 1993.

UNLABELLED: The purpose of this study was to estimate the proportion of pregnancies with pregestational diabetes in Germany, to compare the outcome of these pregnancies to pregnancies in nondiabetic mothers and to identify risk factors for poor pregnancy outcomes in mothers with pregestational diabetes. Data of the "Perinatalerhebung Nordrhine" from 1988-1993 were analysed. The Perinatalerhebung is an ongoing quality assurance programme of prenatal and perinatal care in the region of North Rhine (South Western part of North Rhine-Westphalia). During the observation period a proportion of 93%-100% of the annual births in the region (n = approximately 100000) were included in the study. Their data had been documented by the obstetricians in a standard multiple choice questionnaire. The outcome parameters perinatal mortality, macrosomia, prematurity, and malformations were analysed in relation to several defined explanatory variables. There were 2,402 births in mothers with pregestational diabetes (0.4% of all births). The proportions of poor pregnancy outcomes in women with pregestational diabetes were 2.8% for perinatal mortality, 27.6% for macrosomia, 21.1% for prematurity and 2.1% for malformations . The respective relative risks compared to the non diabetic mothers were 4.3 (95% CI 3.4-5.5) for perinatal mortality, 3.1 (95% CI 2.9-3.3) for macrosomia, 2.7 (95% CI 2.5-2.9) for prematurity and 1.7 (95% CI 1.3-2.3) for malformations . The main risk factor for perinatal mortality in children of diabetic mothers after adjustment for maternal smoking, ethnicity, parents' professional achievement, type of obstetric hospital, and maternal age was substandard use of prenatal care. CONCLUSIONS: The prevalence of births from mothers with pregestational diabetes and their pregnancy outcomes were similar to those in other Western countries. The standard for non-diabetic mothers has not been reached yet. Further improvements may be achieved if all diabetic women are convinced to use the standard prenatal care facilities throughout pregnancy.

Diabetes, Gestational↗
PubMed1987

Experimental evidence for the adaptive value of sexual reproduction.

It is generally believed that recombination by sexual reproduction is unfavourable in constant environments but is of adaptive value under changing environmental conditions. To test this theory, experimental populations of yeast (Saccharomyces cerevisiae) were set up and maintained at different levels of environmental heterogeneity. Recombination was estimated by determining sporulation rates. Sporulation rates first increased in populations living in highly variable environments, but after some time began to decrease. The decrease started last and was slowest in populations which were maintained under the same conditions for a sufficiently long time, to allow some adaptation of the gene pool to the respective environment. Patterns of genotypic variability could not be interpreted in such simple terms, but there was a statistically significant correlation between sporulation rate and genotypic variability. This correlation is to be expected because recombination generates genotypic variability. Summing up, recombination by sexual reproduction is advantageous in changing environments if the population can track the changes in the environment by changing its genotypic structure.

Alleles↗
PubMed1975

Canine osteosarcoma karyotypes from an original tumor, its metastasis, and tumor cells in tissue culture.

Radiation-induced osteosarcoma, its metastasis, and cells grown in tissue culture were karyotyped. Both hypodiploid and hyperdiploid stem lines were observed. The hypodiploid line contained 45-55 chromosomes with 10-15 abnormal metacentric and submetacentric chromosomes and one subtelocentric marker. The hyperdiploid line contained 90-105 chromosomes with 20-30 abnormal metacentric and submetacentric chromosomes with two subtelocentric markers. Karyotypic analysis can be used to monitor osteosarcomas maintained in tissue culture.

Animals↗