A syndrome resembling thrombotic thrombocytopenic purpura associated with Capnocytophaga canimorsus septicemia.
Explore the source record for details and available documents.
Aged↗
Biomedical subjects
H G Williamson
Publications and source records attributed to H G Williamson.
Alcaligenes piechaudii from chronic ear discharge.
A recently described bacterium, Alcaligenes piechaudii, was isolated repeatedly from the ear discharge of a diabetic man. This appears to be the first report of human infection in which there is clinical evidence of a pathogenic role for this species.
Alcaligenes↗
The course of idiopathic dilated cardiomyopathy in New Zealand.
The course of dilated cardiomyopathy in New Zealand was studied in 72 cases that were followed up for less than or equal to 10 years after cardiac catheterisation and coronary angiography. Eighty one per cent were male and 86% were white; the remainder were Maori. The mean age of patients at the time of investigation was 50 X 15 years. Most patients were unskilled labourers. The commonest presenting symptom was dyspnoea and the commonest physical sign was cardiomegaly. Mean survival time from first hospital presentation was 85 months; half the deaths were sudden. Factors predicting a poor survival included cardiomegaly, age, arrhythmias, cigarette smoking, and subclinical thiamine deficiency. The syndrome of dilated cardiomyopathy in New Zealand appears to be identical with that seen in other European populations.
Adult↗
Serological markers of hepatitis B infection in Niue children.
Hepatitis B infection is hyperendemic in the adult population of Niue. In order to determine the age at which infection is acquired and the contribution of vertical and horizontal transmission, the sera from 1055 children were tested for markers of hepatitis B infection. Eleven percent (11.0%) were found to be carriers of hepatitis B surface antigen (HBsAg) and a further 33.6% had antibody to hepatitis B surface antigen (anti-HBs). While less than 15% of the population were infected before the age of two years, these children had the greatest risk of becoming chronic carriers. The simplest method of controlling hepatitis B infection in Niue would be to immunise all newborn babies.
Adolescent↗
Do antibodies to myelin basic protein isolated from multiple sclerosis cross-react with measles and other common virus antigens?
Immunological activity to various antigens, including brain components, measles and other viruses, has been associated with IgG in multiple sclerosis (MS). One possible explanation for the presence of anti-viral antibodies and antibody to myelin basic protein (MBP) in MS patients is that there are antigenic determinants common to certain viruses and MBP. To assess this possibility, IgG from individual brains and sera from patients with MS, subacute sclerosing panencephalitis (SSPE) and controls was isolated by protein A and MBP-Sepharose affinity chromatography. Antibody to MBP was measured with a solid phase radioimmunoassay and antibody to measles and other viruses by immunofluorescence and/or complement fixation. Anti-MBP activity was detected in brain extracts and sera of all MS patients tested. In contrast to the low levels of antibody to MBP in control brains, high levels of anti-MBP antibodies were found in most of the normal sera. There was no correlation between the presence and levels of serum anti-measles antibodies and the anti-MBP activity. None of the anti-MBP antibodies affinity purified from brain and serum of MS patients reacted with any of the viruses tested, including measles. IgG purified from SSPE patients or from a rabbit hyperimmunized with measles antigen had no reactivity to MBP, despite high levels of anti-measles antibody. It is concluded that there is not direct link between the presence of antibody to MBP and antibody to measles and other viruses in MS patients.
Adenoviridae↗
A longitudinal study of hepatitis infection in an institution for the mentally retarded.
The natural history of hepatitis A and B infections in a large institution for the mentally retarded were studied over an eight year period. Serum samples were obtained from most subjects on three occasions and tested for anti-HAV, HBsAg, anti-HBs and occasionally anti-HBc, by solid-phase radioimmunoassay. Hepatitis A was found to have been a common infection was 74.8% of subjects having detectable levels of antibody. The virus does not appear to be endemic, as the prevalence of antibody in children admitted since the last outbreak was no higher than amongst non-institutionalised children. The infection rate amongst subjects with Down's syndrome (DS) was higher than amongst subjects with other forms of mental retardation (OMR), and more than 95% of infections in both groups were unrecognised. By contrast with hepatitis A, hepatitis B virus was endemic in the institution with 81.2% of residents showing serological evidence of current or past infection. Of these, 40.8% of subjects with DS and 9.2% of those with OMR were found to be chronic carriers. The carrier rate was higher in males than females and tended to be more prolonged in subjects with DS. During the study period, the predominant subtype of HBsAg detected in the institution changed from adw to ayw.
Adolescent↗
Human rotavirus infection in Efate, Vanuatu.
Serum and fecal samples collected from children with gastroenteritis and healthy children and adults living in Efate, Vanuatu (formerly the New Hebrides), were tested for the presence of human rotavirus antigen or antibody by electron microscopy and enzyme-linked immunosorbent assay. Virtually every subject was found to have detectable levels of antibody and age-specific studies showed that primary infections occur early in life. Human rotavirus was demonstrated to be the cause of an outbreak of gastroenteritis among children which occurred between August and September 1980, although it had not been detected in the population in the preceding 13 months. Epidemics of human rotavirus-associated gastroenteritis appear to occur every 2nd year in this population.
Adolescent↗
Coronavirus-like particles and other agents in the faeces of children in Efate, Vanuatu.
Between June 1979 and July 1980, faecal specimens were collected from 100 children in Efate, Vanuatu, and examined for the presence of virus-like particles by direct negative staining electron microscopy. Of the children, 40 were hospital patients 22 of whom had gastroenteritis and 18 had other illnesses. The remaining 60 children were apparently healthy controls. Coronavirus-like particles were the most common agents encountered and were detected in approximately 20% of all three groups of children. Particles with the morphological features of calicivirus, astrovirus, adenovirus and parvovirus were also detected.
Adenovirus Infections, Human↗
Maintenance dialysis of patients infected with hepatitis B virus.
Haemodialysis of patients who were acutely or chronically infected with hepatitis B virus has been undertaken at Fairfield Hospital for Communicable Diseases for the past 10 years. Over this period, only one staff member has shown serological evidence of infection. The procedures taken to prevent the spread of infection, and the results of an ongoing serological survey of all persons associated with the haemodialysis unit are presented.
Carrier State↗
Echovirus type 11 infection in Melbourne--1953 to 1980.
Echovirus type 11 (echo 11) has been isolated at the virus laboratory of Fairfield Hospital, Melbourne, Australia, in 20 of the 28 years since the laboratory was established. During this time two major epidemics have occurred; the first, in 1971-2 involved 90 patients with aseptic meningitis or respiratory illness. The second began in June 1979 and lasted for 11 months, during which echo 11 was isolated from 174 patients admitted to Fairfield Hospital, other Victorian and Tasmanian hospitals and a children's reception centre. The patients' illnesses included viral meningitis (66%), fever (10%), respiratory infections (7%) and gastroenteritis (2%). One baby died. Echo 11 was recovered from nasopharyngeal swabs or aspirates, cerebrospinal fluid and faecal specimens and was isolated most frequently in the Borrie cell line. Isolates were readily identified by immune electron microscopy and/or neutralization tests.
Adolescent↗
Errors in derived kinematic variables determined from a fixed accelerometer configuration.
Previous authors have described the unstable nature of the differential equations to be solved in order to derive angular velocity components of a rigid body from an accelerometer configuration mounted on the body. Suggestions for alternatives have been made using redundant accelerometers or a combination of accelerometers and gyros. It is the purpose of this paper to present the errors in derived linear and angular kinematic variables consistent with a particular 3-2-1 accelerometer configuration for acceleration experiments conducted at the Naval Biodynamics Laboratory (NBDL). Accelerometer errors of sensitivity, linearity and orientation are considered. The statistics of those errors are obtained from repetitive calibrations of the instrumentation packages and are consistent with the calibration techniques at NBDL. Worst case combinations of the standard deviation errors in sensitivity, linearity and orientation are presented. The performance of the six-accelerometer configuration is compared with the least squares solution using three triaxial accelerometers.
Acceleration↗