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Biomedical subjects

H G Morgan

Publications and source records attributed to H G Morgan.

At least 19 recordsLinked to original sources
PubMed1991

Suicide and other unexpected deaths among psychiatric in-patients. The Bristol confidential inquiry.

By matching information collected from coroner inquest records with hospital admission and discharge registers, 27 suicides and 5 other unexpected deaths were identified over 30 months among persons who either were psychiatric in-patients at the time or had been up to eight weeks previously. The relevant consultant completed a questionnaire concerning assessment and management in each case. It is suggested that such an approach might usefully be adopted widely as an audit of unexpected deaths. In 20 of the suicides the seriousness of the risk was not fully recognised; 13 absented themselves from the hospital ward without leave. Misleading clinical improvement in the absence of corresponding alleviation of situational problems, and patient alienation appeared important hazards. The findings have implications for service development, particularly when major reduction of bed numbers is planned.

Adult↗
PubMed1990

The transmission of onchocerciasis at a forest village in Sierra Leone. I. Simulium damnosum s.l. biting densities and infection with Onchocerca volvulus at five representative sites.

Previous studies in the forest area of Sierra Leone have shown that transmission of Onchocerca volvulus takes place many kilometers away from large breeding rivers and sometimes in open farmland. To determine where and when people in a forest village were most likely to be infected, catches of Simulium damnosum s.l. were carried out every week for 12 months, at five sites in and near a village where onchocerciasis was mesoendemic. The number of flies caught per man a day at open farm sites was significantly higher than the number caught at riverside sites. Infective flies were caught only in farmland and only during the early rainy season. The combined Annual Transmission Potential for the five sites was 129 larvae per man per year. Isoenzyme electrophoresis and morphology of biting flies identified the S. sanctipauli/soubrense subcomplex as the most common vector species. Simulium yahense and S. squamosum were sometimes present. It was concluded that the classical riverside monitoring sites do not represent high risk areas for the transmission of onchocerciasis in a forest village sited well away from the main S. damnosum s.l. breeding sites. The highest risk areas are in open farmland.

Animals↗
PubMed1990

Managing suicide risk in the general ward.

In this paper we look first at those groups and situations which denote a high risk for suicide. Thorough assessment, which is the first essential step in approaching any clinical problem, is then addressed. Finally we consider the many potential hazards that may complicate assessment and management of individuals at risk of killing themselves.

Emergencies↗
PubMed1988

Clinical assessment of anorexia nervosa. The Morgan-Russell outcome assessment schedule.

The Morgan-Russell outcome assessment schedule is described and statistically analysed with reference to two independent series of patients suffering from anorexia nervosa. The value of check lists and simple scaling of data is emphasised as one way of improving the standards of routine case-note documentation in clinical psychiatric practice.

Anorexia Nervosa↗
PubMed1987

Our response to AIDS.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Functional vomiting.

Explore the source record for details and available documents.

Adaptation, Psychological↗
PubMed1979

The effects of cholestyramine on high density lipoprotein metabolism.

This study on 4 type II hyperlipoproteinaemic subjects examines the effects of pharmacologic doses (8 g twice daily) of the bile acid sequestrant cholestyramine on the plasma distribution and chemical composition of the high density lipoprotein subfractions, HDL2 and HDL3, and describes the influence of the drug on the metabolism of the major HDL aporoteins, apolipoprotein A-I and A-II. Cholestyramine lowered plasma low density lipoprotein cholesterol (32%; P less than 0.05) without affecting the level of that lipid in very low density or high density lipoproteins. However, the plasma HDL2/HDL3 ratio and apolipoprotein A-I concentration rose significantly on treatment, while apolipoprotein A-II remained unchanged. The rise in apolipoprotein A-I derived from an increase in its synthetic rate and produced a relative enrichment of the protein with respect to apolipoprotein A-II in both HDL subfractions. These results demonstrate the cholestyramine treatment affects HDL metabolism in a way which, according to current concepts, may prove beneficial to the recipient.

Apolipoproteins↗
PubMed1979

Severe hypokalemia in hospitalized patients.

Profound hypokalemia was observed in 73 patients in a major university teaching hospital during a three-year period. When compared with hospitalized subjects used as controls, these patients experienced a greater mortality, were substantially more likely to be female, but were not more likely to suffer from cardiovascular disease. Use of a diuretic appeared to precipitate profound hypokalemia infrequently, and when it did, the clinical situation was extremely complex. Over 10% of the patients with hypokalemia had acute myeloid leukemia, an incidence 22 times greater than that expected. Hypokalemia should be sought in all patients with this disease, since it is an avoidable cause of death. Further studies into the mechanism of hypokalemia are required to explain its striking preponderance in women.

Cardiovascular Diseases↗
PubMed1977

Lipoprotein concentrations in untreated adult onset diabetes mellitus and the relationship of the fasting plasma triglyceride concentration to insulin secretion.

Plasma lipoprotein concentrations in 64 untreated adult onset diabetics were compared to the lipoprotein levels found in non diabetics. No significant difference was found. The relationship of the fasting plasma triglyceride concentration to the plasma immunoreaction insulin response to 50 g glucose orally was investigated. Using correlation analysis a significant and insulin response in the non diabetics but not in the diabetics.

Cholesterol↗
PubMed1976

Radioimmunoassay for human plasma apolipoprotein B.

We have developed a simplified double antibody radioimmunoassay for human apolipoprotein beta. The purified antigen, a narrow density subclass of beta lipoprotein (d 1.030-1.050 g/ml; was isolated by a combination of gel filtration and ultracentrifugationmthis material gave a single immunoprecipitin arc on crossed immunoelectrophoresis into an antibody to whole human serum. The antigen was radiolabelled using iodine monochloride at pH 10. The iodinated antigen was indistinguishable immunochemically from native material and eluted as a single radioactive peak from a Sephadex G-200 column. The lower limit of sensitivity of the assay was 15 ng protein, and the working range, 15-200 ng. The mean apolipoprotein B level (+/-1 S.D.) in 128 healthy control subjects was 86.6 +/- 29.6 mg/100ml and is in agreement the values published by other workers using unmodified assays.

Apoproteins↗