Biomedical subjects

H G E Hentschel

Publications and source records attributed to H G E Hentschel.

7 recordsLinked to original sources

PubMed2005

On multiscale approaches to three-dimensional modelling of morphogenesis.

In this paper we present the foundation of a unified, object-oriented, three-dimensional biomodelling environment, which allows us to integrate multiple submodels at scales from subcellular to those of tissues and organs. Our current implementation combines a modified discrete model from statistical mechanics, the Cellular Potts Model, with a continuum reaction-diffusion model and a state automaton with well-defined conditions for cell differentiation transitions to model genetic regulation. This environment allows us to rapidly and compactly create computational models of a class of complex-developmental phenomena. To illustrate model development, we simulate a simplified version of the formation of the skeletal pattern in a growing embryonic vertebrate limb.

Animals↗

PubMed2005

Synchronization is enhanced in weighted complex networks.

The propensity for synchronization of complex networks with directed and weighted links is considered. We show that a weighting procedure based upon the global structure of network pathways enhances complete synchronization of identical dynamical units in scale-free networks. Furthermore, we numerically show that very similar conditions hold also for phase synchronization of nonidentical chaotic oscillators.

Biophysics↗

PubMed2004

Synchronization of spatially extended chaotic systems in the presence of asymmetric coupling.

In a recent paper [Phys. Rev. Lett. 91, 064103 (2003)]] we described the effects of asymmetric coupling configurations on the synchronization of spatially extended systems. In this paper, we report the consequences induced by the presence of asymmetries in the coupling scheme on the synchronization process of a pair of one-dimensional fields obeying complex Ginzburg-Landau equations. While synchronization always occurs for large enough coupling strengths, asymmetries have the effect of enhancing synchronization and play a crucial role in setting the threshold for the appearance of the synchronized dynamics, as well as in selecting the statistical and dynamical properties of the synchronized motion. We analyze the process of synchronization in the presence of asymmetries when the dynamics is affected by the presence of phase singularities, and show that defects tend to anchor one system to the other. In addition, asymmetry controls the number of synchronized defects that are present in the dynamics. Possible consequences of such asymmetry induced effects in biological and natural systems are discussed.

Journal Article↗

PubMed2004

Dynamical mechanisms for skeletal pattern formation in the vertebrate limb.

We describe a 'reactor-diffusion' mechanism for precartilage condensation based on recent experiments on chondrogenesis in the early vertebrate limb and additional hypotheses. Cellular differentiation of mesenchymal cells into subtypes with different fibroblast growth factor (FGF) receptors occurs in the presence of spatio-temporal variations of FGFs and transforming growth factor-betas (TGF-betas). One class of differentiated cells produces elevated quantities of the extracellular matrix protein fibronectin, which initiates adhesion-mediated preskeletal mesenchymal condensation. The same class of cells also produces an FGF-dependent laterally acting inhibitor that keeps condensations from expanding beyond a critical size. We show that this 'reactor-diffusion' mechanism leads naturally to patterning consistent with skeletal form, and describe simulations of spatio-temporal distribution of these differentiated cell types and the TGF-beta and inhibitor concentrations in the developing limb bud.

Animals↗

PubMed2004

Anisotropic diffusion-limited aggregation.

Using stochastic conformal mappings, we study the effects of anisotropic perturbations on diffusion-limited aggregation (DLA) in two dimensions. The harmonic measure of the growth probability for DLA can be conformally mapped onto a constant measure on a unit circle. Here we map m preferred directions for growth to a distribution on the unit circle, which is a periodic function with m peaks in [-pi,pi) such that the angular width sigma of the peak defines the "strength" of anisotropy kappa= sigma(-1) along any of the m chosen directions. The two parameters (m,kappa) map out a parameter space of perturbations that allows a continuous transition from DLA (for small enough kappa ) to m needlelike fingers as kappa--> infinity. We show that at fixed m the effective fractal dimension of the clusters D(m,kappa) obtained from mass-radius scaling decreases with increasing kappa from D(DLA) approximately 1.71 to a value bounded from below by D(min) = 3 / 2. Scaling arguments suggest a specific form for the dependence of the fractal dimension D(m,kappa) on kappa for large kappa which compares favorably with numerical results.

Journal Article↗

PubMed2004

Diffusion-limited aggregation with power-law pinning.

Using stochastic conformal mapping techniques we study the patterns emerging from Laplacian growth with a power-law decaying threshold for growth R(-gamma)(N) (where R(N) is the radius of the N-particle cluster). For gamma>1 the growth pattern is in the same universality class as diffusion limited aggregation (DLA), while for gamma<1 the resulting patterns have a lower fractal dimension D(gamma) than a DLA cluster due to the enhancement of growth at the hot tips of the developing pattern. Our results indicate that a pinning transition occurs at gamma=1/2, significantly smaller than might be expected from the lower bound alpha(min) approximately 0.67 of multifractal spectrum of DLA. This limiting case shows that the most singular tips in the pruned cluster now correspond to those expected for a purely one-dimensional line. Using multifractal analysis, analytic expressions are established for D(gamma) both close to the breakdown of DLA universality class, i.e., gamma less, similar 1, and close to the pinning transition, i.e., gamma greater, similar 1/2.

Journal Article↗

PubMed2002

Conformal map modeling of the pinning transition in Laplacian growth.

In Laplacian growth processes pinning may be expected due to a nonlinear response of a material during dielectric breakdown, or due to stick-slip boundary conditions in two-fluid flow in a porous medium, while thermal noise will lead to depinning. Using a method recently proposed by Hastings and Levitov, the size R(max) approximately E(-alpha)(c) of the pinned pattern is shown to scale with the critical field E(c) (electric field for dielectric breakdown, pressure gradient for fluid flow). These pinned patterns have a lower effective fractal dimension d(f) than diffusion-limited aggregation due to the enhancement of growth at the hot tips of the developing pattern. At finite temperature, thermal noise leads to depinning and growth of patterns with a shape and dimensionality dependent on both E(c) and the thermal noise. Using multifractal analysis, scaling expressions are established for this dependency.

Journal Article↗