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Biomedical subjects

H G Classen

Publications and source records attributed to H G Classen.

At least 73 records · Page 4Linked to original sources
PubMed1975

[Chromaffine tumours: diagnosis and catamnestic features based on the data collected at the Institute of Experimental Therapy between 1949 and 1974 (author's transl)].

From 1949 to 1974, urine samples of 1669 patients with unclarified arterial hypertension were tested for non-conjugated catecholamines. Chromaffine tumours--among them one pheochromoblastoma and two families with inherited forms--were found in 1.1% of all cases. With the procedure applied, adrenergic alpha- and/or beta-mimetic actions on the circulation of cats can be identified when the excretion of total catecholamines is increased by the factor 1.5 to 2.0. Hence, chromaffine tumours with smaller excretion rates (about 200 mug/24 h) are also detectable, so in one case where the excretion of vanillyl-mandelic acid was normal. Thus all prerequisites concerning sensitivity and specificity of a screening method are fulfilled. The large variety of symptoms of chromaffine tumours becomes obvious from the catamnestic data of 19 patients indicating problems which may arise in differential diagnosis.

Adolescent↗
PubMed1975

Improvement by chlorine of the intestinal absorption of inorganic and organic Mg compounds and of their protective effect against adrenergic cardiopathy.

Comparative studies on the therapeutic effects of MgSO4, MgCl2, Mg aspartate, and Mg aspartate hydrochloride were carried out in Sprague-Dawlwy rats. In general, the intestinal absorption of Mg and its uptake into bone were improved after oral or intraduodenal administration of the two compounds containing chlorine; however, in these animals, gain in body weight was reduced, especially after MgCl2. Treatment with 9-alpha-fluorocortisol plus epinephrine resulted in cardiac hypertrophy and necroses. All Mg compounds fed in amounts leading to marked hypermagnesemia prevented hypertrophy; as regards the incidence and severity of necroses, however, MgSO4 and Mg aspartate proved ineffective. Significant protective effects were observed only after MgCl2 and Mg aspartate hydrochloride, indicating the central pathogenic role of extracellular hypochloremic alkalosis in metabolic heart necroses.

Animals↗
PubMed1975

Platelet aggregation induced by anaphylatoxin and its inhibition.

Anaphylatoxin (AT), a splitting product of the fifth component of the complement system can be prepared by incubation of rat plasma with low-molecular weight dextran (MW 2000) at 37 degrees C, or by treatment with cobra venom factor. Using the turbidimetric method of Born the effect of AT was studied on platelets from man, dog, rabbit, cat, guinea pig, and rat. AT was found to induce aggregation only in platelet rich plasma from cat and guinea pig. This aggregation could be reduced by several known inhibitors of aggregation and platelet function, such as phentolamine, tosylarginine-methylester (TAMe), p-chloromercuribenzoate (PCMB), and ethylenediamine-tetraacetic acid (EDTA) whereas adenosine, methysergide-bimaleinate, and mepyramine-maleate proved to be ineffective. Experiments with PCMB and TAMe suggest a release reaction induced by AT. Further more, there is evidence that with platelets from guinea pigs AT produces some tachyphylactic state.

Adenosine↗