Search PubMed⌕ Search

Biomedical subjects

H G Borst

Publications and source records attributed to H G Borst.

At least 127 records · Page 7Linked to original sources
PubMed1988

Treatment of extensive aortic aneurysms by a new multiple-stage approach.

A new multiple-stage approach to extensive aneurysmal disease of the aorta is presented. The method is designed to obviate the proximal graft-to-aorta anastomosis in second-stage and third-stage aortic replacement to simplify and facilitate these operative steps. Since 1981 a total of 17 such procedures were performed in seven patients with dissecting and nondissecting aneurysms without deaths or complications related to the method.

Adult↗
PubMed1987

[Heart transplantation--status and perspectives].

Transplantation of the heart (HTx) has become a realistic procedure in the treatment of terminal cardiac failure. However, several problems remain and are to be discussed on the basis of our experience in 160 cases of HTx. A dramatic widening of indications for HTx presently is not to be expected while the lack of donor organs is magnified by the growing transplantation frequency. This bottle neck only can be lessened by mobilization of all organ sources. Longterm survival rate in HTx patients seems to stabilize at well over 70%. Persisting mortality and morbidity of HTx are the result of imperfect recognition and treatment of rejection as well as infection. The use of circulatory aids in patients expecting HTx and in those with a failing transplant is of growing importance at the same time posing the problem of high urgency in patients thus instrumented. It is likely that the intermediate-term use of the totally implantable artificial heart will lessen this dilemma. Costs and efforts of cardiac transplantation are considerable. A plea therefore is made for concentration of organ transplantations of all types in special centers.

Heart Failure↗
PubMed1987

Results of orthotopic heart transplantation for ischaemic cardiomyopathy.

From July 1983 to May 1987, 172 orthotopic heart transplantations were performed in 165 patients. Of these, 46 recipients (39 male, 7 female), aged between 26 and 56 years (mean age 47), suffered from ischaemic cardiomyopathy. Postoperative immunosuppression consisted of a triple drug regimen of cyclosporine A, azathioprine and, in the last 31 patients, low-dose steroids. The actuarial survival in this group of patients at 1 year and at 2 years was 71.9%. There were five early deaths: three due to acute rejection and two from multiple-organ failure and sepsis. Of the eight late deaths, two could be attributed to acute cardiac rejection and four to bacterial infections. In two patients, sudden death occurred in the presence of accelerated graft atherosclerosis. Mild-to-moderate coronary artery lesions were seen in five other patients undergoing angiography one year after transplantation. Apart from the well-known postoperative risk factors in cardiac transplant recipients, accelerated graft atherosclerosis appears to be an additional hazard in the subgroup surgically treated for ischaemic cardiomyopathy.

Adult↗
PubMed1987

A new look at acute type-A dissection of the aorta.

A new method of treating acute type-A dissection of the aorta is described and illustrated. It involves the reconstruction of both the valve and the ascending aorta. This procedure was employed in 17 patients, 2 of whom succumbed early of complications unrelated to the method while one committed suicide at a later date. One of the surviving patients required reoperation due to breakdown of a resuspended aortic commissure. Two patients show minor non-progressive valve regurgitation in the absence of annulo-aortic ectasia. Two patients have developed dilatation of the aortic root--one will require reoperation in the foreseeable future. In our hands, this method has served to make emergency operation for acute aortic dissection both simpler and safer. The limitations of its use are discussed.

Acute Disease↗
PubMed1987

Occlusion of intercostal and lumbar aortic branches using plastic plugs.

Retrograde bleeding from the orifices of intercostal and lumbar arteries during aortic surgery is usually controlled by suture placement, a procedure that is time-consuming and may result in considerable blood loss. We have devised a method of occluding these arteries using polyurethane plugs. We have experienced no instances of perforation or delayed bleeding using this technique.

Aorta↗
PubMed1987

Late increase in luminal diameter of aortocoronary venous bypass grafts associated with an increase in the vascular region under supply.

In a previous study, a significant inverse relation was found between the luminal size of aortocoronary venous bypass grafts and the vascular resistance of the coronary region that was perfused by the bypass graft in late stages after bypass surgery. This observation suggested that changes in the graft-dependent vascular area could influence the luminal size of the vein graft, even when they occurred several years after operation. Whereas it is well established today that aortocoronary vein grafts often decrease in luminal diameter after implantation, an increase in the bypass lumen has so far not been reported. Therefore, changes in luminal diameter of 27 vein grafts in 21 patients who underwent at least two postoperative angiographic studies (first study 8 +/- 5 months after surgery, second study 58 +/- 32 months after surgery) were compared with the size of the vascular region supplied by the bypass. The graft diameter was found to be unchanged between the two studies (3.3 +/- 0.6 versus 3.4 +/- 0.7 mm, p = NS) when the dependent vascular area was unchanged. A significant increase in graft diameter from 2.8 +/- 0.8 to 3.9 +/- 0.9 mm (p less than 0.001) was observed in nine patients in whom the area of perfusion had increased between the two studies because of the development of occlusion or obstruction of major coronary branches that were now perfused from the grafted vessel by way of collateral vessels. These data support the contention that the luminal size of aortocoronary vein grafts can adapt to the needs of the dependent myocardial vascular region even late after operation rather than being the result of a nonreversible degenerative process as commonly assumed.

Adult↗
PubMed1987

Surgical decision making in acute aortic dissection type A.

In principle there are 3 different approaches to the treatment of acute aortic dissection type A (AADA): replacement of the aortic valve and ascending aorta, reconstruction of these structures, and a combination of both techniques. This study summarizes our experiences with these methods and delineates indication for the different surgical procedures. Since 1979, a total of 51 patients (39 male, 12 female, mean age 45.5 years) underwent surgery for AADA with an overall mortality of 25%. Differences in mortality of the operative variants (reconstruction 12%, composite replacement 18%, combined reconstruction and replacement 47%) predominantly mirror growing experience than applicability of the methods. The follow-up of patients with reconstruction of the aortic valve revealed a reoperation rate of only 9% after 0.3 to 6.3 years. Four patients with constant and minor annuloectasia and/or subclinical aortic insufficiency are observed in short intervals. We conclude, that the operative procedure in AADA must be adapted to the intraoperative pathoanatomical findings. Patients with primary annuloectasia should undergo graft replacement. Reconstruction of the ascending aorta and aortic valve is considered to be the preferable method in patients with primarily normal caliber of the ascending aorta and aortic anulus.

Adult↗
PubMed1987

[Heart transplantation--postoperative management].

Heart transplantation represents a widely accepted therapeutic modality for patients with end-stage myocardial failure. With increasing experience, 1-year survival rates of over 75% and 5-year survival rates of over 60% have been achieved, mainly due to patient selection, standardized surgical techniques as well as improved postoperative management. During early follow-up, particular attention should focus on diagnosis and treatment of graft rejection and infection, which require individualized immunosuppression, while in the later postoperative course coronary atherosclerosis, hypertension, chronic renal insufficiency and malignancy become more important as potential complications. The general principles in the management of these patients are discussed.

Adolescent↗