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H Furuya

Publications and source records attributed to H Furuya.

At least 235 records · Page 13Linked to original sources
PubMed1989

[Osseointegrated implants in clinical dentistry. Practice of osseointegration implants].

The average life span of the Japanese has grown to 75.61 years for men and 81.39 years for women: both Japanese men and women have the longest life spans of any peoples in the world. The Welfare Ministry has urged a review of the social security system including medicine and pensions, and is seeking to establish lives worth living in our old age for the coming aging society, because there is no sign of the increase in the average life span slowing down. Various functions of the living body change physiologically with aging. Figure 1 shows a well-known graph showing "Changes in Physiological Functions with Aging" reported by Shock in 1971. It shows that systemic basic metabolism decreases almost linearly with age after about 30 years that reaches the peak of body functions, as well as almost all autonomic functions, including the kidney, lung, heart, and nerves. The speed at which functions decrease varies with organs. The age when functions begin to decrease differs between individuals. Generally, however, the ability of the eye to adjust makes us aware of aging at the earliest stage of life. The distribution of all elements comprising a body decreases with age, except for extracellular fluid. There are many difficulties in establishing lives worth living in old age, because of the fact that aged people suffer from reduced physiological and physical functions. The pleasure of eating may be one of the things that make life worth living. Many aged people seem to wish that they could enjoy meals as they did in their youth.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1989

Clinical features and diagnosis by recombinant DNA techniques of familial amyloid polyneuropathy in Japan.

Diagnosis of familial amyloid polyneuropathy (FAP) was investigated by recombinant DNA techniques using Southern blot hybridization in 49 constituents of FAP pedigrees originated from Nagano and Hiroshima Prefectures in Japan. The results were correlated with clinical features of the patients. Twenty-nine patients originated from Ogawa Village in Nagano Prefecture of the central part of Japan had typical clinical features of Andrade type FAP including polyneuropathy with autonomic disorders. The variant prealbumin gene with a substitution of methionine (Met) for valine (Val) at position 30 was detected in their DNA analysis (positive DNA diagnosis). In 5 cases from Nagano and Hiroshima Prefectures who had clinical features of Andrade type FAP but no family history, DNA diagnosis was positive. In another 5 members of FAP pedigrees originated from Ogawa Village without clinical features of FAP, DNA diagnosis was positive. Two cases originated from Iiyama City in Nagano, who had central nervous system disorders resembling spinocerebellar degeneration with spastic paraplegia besides clinical features of Andrade type FAP, had the Val-Met interchange variant prealbumin gene. In a case from the same Iiyama family who had only the central nervous system disorders without clinical features of FAP, DNA diagnosis was negative. These findings indicate that the presence of the variant prealbumin gene closely linked to the clinical manifestations of Andrade type FAP. The diagnostic DNA analysis was considered to be useful for the diagnosis of Andrade type FAP for sporadic cases as well as so far nonsymptomatic gene carriers. In conclusion, FAP patients originated from Iiyama City and Ogawa village were considered to have the same mutation despite the variances in clinical features.

Adult↗
PubMed1989

Human transthyretin (prealbumin) gene and molecular genetics of familial amyloidotic polyneuropathy.

Transthyretin (TTR, also called prealbumin) is a plasma protein produced in liver. The variant types of TTR are known to be closely associated with familial amyloidotic polyneuropathy (FAP), an autosomal dominant genetic disorder. This article summarizes, together with some new data, our current knowledge on FAP from the view point of molecular genetics. As an initial step towards understanding the disease at the DNA level, the complete nucleotide sequence of the human TTR gene (-7 kb to 7 kb; 1 kb = 10(3) bases) was determined and analyzed. The gene is located on chromosome 18 q12.1 and consists of four exons. Homology search revealed that there exist several possible regulatory signals in the 5' flanking region of the gene, including the binding sites for liver-specific nuclear factors HNF-1, 3, 4 and C/E BP, which have been previously identified in mouse TTR gene. Sequence analysis enabled us to identify all the mutations related to various types of FAP. The mutations were shown to be almost completely linked to FAP and it has become possible to diagnose FAP even at presymptomatic (prenatal) stages by recombinant DNA technology, with a high reliability. Haplotype analysis of FAP families using DNA polymorphic markers in the TTR locus suggested that the Val30----Met mutation closely related to type I FAP, the most common type of FAP, has frequently recurred in the human population to generate FAP families of independent origin. Although the primary cause of FAP has become clear, extensive screening of FAP families in various locations suggested that the expression of FAP is a complicated process and affected by some unknown factors (other than TTR).(ABSTRACT TRUNCATED AT 250 WORDS)

Amyloidosis↗
PubMed1989

[The alterations of serum colloid osmotic pressure, serum protein and water balance during prolonged anesthesia].

The changes of serum colloid osmotic pressure (COPm), serum protein and water balance were examined in 9 patients during and for 2 weeks after operation which required prolonged anesthesia. The values of serum total protein (TP), serum albumin (Alb) and COPm decreased by about 17% three hours after the start of anesthesia and by 15%, 20% and 24%, respectively, after 18 hours. These values returned to each preoperative value about one week after the operation. The correlation coefficients (the values in parentheses were calculated using data obtained during anesthesia) comparing COPm to TP, Alb and calculated colloid osmotic pressure (Landis' equation) were 0.661 (0.710), 0.480 (0.649) and 0.666 (0.727). There was no correlation between COPm and water balance. When COPm was 17.5mmHg or lower, calculated colloid osmotic pressure value was higher than COPm as the Alb/TP ratio decreased. Decreases in the values of COPm and serum protein during operation were considered to have been caused mainly by increased capillary permeability.

Anesthesia↗
PubMed1988

Amyloid beta-protein gene duplication is not common in Alzheimer's disease: analysis by polymorphic restriction fragments.

The amyloid beta-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized that sporadic AD may involve the duplication of a subregion of chromosome 21 containing the BP locus. However, an improved method for detection of the BP gene duplication using polymorphic Hind III fragments led us to a conclusion that BP gene duplication is rare, if any, in (Japanese) sporadic AD patients, indicating that the duplication of the BP gene itself is not the common underlying genetic defect in AD.

Adolescent↗
PubMed1988

Therapeutic effectiveness and plasma levels of single or combination use of class I antiarrhythmic agents for ventricular arrhythmias.

The efficacy of disopyramide (DP), mexiletine (MX), aprindine (AP) and cibenzoline (CZ) on ventricular arrhythmias was compared (single drug therapy). In addition, the efficacy of the combination therapy of DP with MX was also studied (combination therapy). One hundred of the 106 patients completed the protocol of the single drug therapy. Fifty percent or more reduction in the frequency of ventricular premature contractions (VPCs) was obtained in 24 of 43 patients (56%) with DP, in 24 of 44 (55%) with MX, in 18 of 29 (62%) with AP and 10 of 18 (56%) with CZ. AP was comparatively more effective than the other drugs tested. DP was significantly effective on VPCs with organic heart disease as compared to idiopathic VPCs (p less than 0.05), while the other 3 drugs did not have such a tendency. With MX therapy, 10 of the 12 patients with fast VT rate (greater than or equal to 150 beats/min) showed a significant effect while only 4 of the 12 patients with non-fast VT rate (greater than or equal to 100 and 150 beats/min) had a significant one (p less than 0.05). On the other hand, DP, AP and CZ showed almost the same efficacy at any cycle length of VT. Six patients withdrew from the study, 4 because of digestive troubles with MX therapy, 1 because of micturition disturbances with DP and 1 because of skin rash with AP. The average therapeutic plasma levels of DP, MX, AP and CZ were 1.76 +/- 0.54 microgram/ml, 1.08 +/- 0.41 microgram/ml, 0.85 +/- 0.43 microgram/ml and 268.2 +/- 123.3 ng/ml, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1987

Complementary DNA for the mouse homolog of the human amyloid beta protein precursor.

The human amyloid beta protein is a major component of brain amyloid found in patients with Alzheimer's disease. As an initial step to understand the biological function of its precursor protein, we have isolated cDNA for the mouse homolog of the human beta protein precursor. Comparison of the predicted amino acid sequence with that of human revealed a quite high degree of homology (96.8%), and the calculated evolutionary rate of the mRNA at amino acid substitution site was relatively low (0.1 x 10(-9)/site/year). The mRNA was abundant in brain and kidney, and also detected in other tissues at low level. These results indicated that this protein is highly conserved through mammalian evolution and may be involved in a basic biological process(es).

Amino Acid Sequence↗
PubMed1987

Biochemical and genetic characterization of type I familial amyloidotic polyneuropathy.

Type I familial amyloidotic polyneuropathy is an autosomal dominant, inherited systemic amyloidosis characterized initially by dissociated sensory disturbance and autonomic dysfunction. The amyloid fibril protein seen in patients of Portuguese, Japanese, and Swedish descent in the U.S. mainly consists of a variant form of transthyretin (also called prealbumin) with the substitution of methionine for valine at position 30. Methods have been developed to detect this variant transthyretin in the serum, and to detect a base change in a mutated transthyretin gene. The biochemical and genetic abnormalities in transthyretin are completely linked to the clinical diagnosis of type I familial amyloidotic polyneuropathy. These diagnostic methods may allow early diagnosis and genetic counseling to avoid transmission of this intractable disorder to the next generation.

Amyloidosis↗
PubMed1987

"Sporadic" prealbumin-related amyloid polyneuropathy: report of two cases.

Two "sporadic" cases of amyloid polyneuropathy are reported. There was no family history or plasma cell dyscrasia. Both showed sensorimotor and autonomic polyneuropathy with onset in the seventh decade. Amyloid deposits in both cases reacted with anti-human prealbumin sera but not with antisera to human AA and anti-human immunoglobulin light-chain amyloids, including A kappa and A lambda. One patient had the abnormal serum prealbumin and abnormal DNA sequence found in type I familial amyloid polyneuropathy (FAP)(Japanese type). Investigations in "sporadic" amyloid polyneuropathy should include immunohistochemistry, using antisera to the different amyloid proteins, and the radioimmunoassay and recombinant DNA techniques for diagnosis of FAP.

Aged↗
PubMed1987

The effects of halothane and pentobarbital on the threshold of transpulmonary passage of venous air emboli in dogs.

The influence of halothane, pentobarbital, and their interaction on the passage of air across the pulmonary circulation was studied in 12 dogs using transesophageal M-mode echocardiography for air detection in the left atrium and/or aorta. Air was detected in the left atrium and/or aorta after pulmonary artery air injection of 0.04 ml/kg during 1% halothane anesthesia (n = 5). Addition of pentobarbital changed the threshold to 1.0 ml/kg. During pentobarbital anesthesia with and without halothane (n = 7), the thresholds were 1.1 and 1.2 ml/kg, respectively. The authors conclude that the threshold for transpulmonary passage of venous air is higher during anesthesia with pentobarbital with or without halothane than during anesthesia with halothane alone.

Anesthesia, General↗
PubMed1987

Molecular analysis of a variant type of familial amyloidotic polyneuropathy showing cerebellar ataxia and pyramidal tract signs.

A Japanese family with atypical type I familial amyloidotic polyneuropathy (FAP) in Iiyama, Japan was studied. Most of the family members have dysfunctions in the central nervous system, in addition to typical symptoms of type I FAP. The transthyretin (TTR, also called prealbumin) gene of the atypical FAP(FAP-IY) was analyzed with recombinant DNA techniques and a RIA method. FAP-IY was found to have the mutation responsible for the methionine-for-valine substitution at position 30 of TTR, as in the case of typical type I FAP. However, analysis of DNA polymorphisms in the TTR locus showed that FAP-IY has a genetic background differing from that of the typical type I FAP. These observations lead to the consideration that a genetic factor(s) involved in the dysfunction of the central nervous system may locate in a chromosome region in close proximity to the TTR gene.

Amyloidosis↗
PubMed1987

[Ca2+, phospholipid-dependent protein kinase (C-kinase) in the rat placental chorion].

C-kinase is one of the enzymes which phosphorylate cellular proteins, and is reported to be involved in transmission of the extracellular signals regarding hormones, etc. to inside the cell. This enzyme is widely distributed in many tissues and organs and several C-kinase-mediated cellular responses were reported. However, in the placenta, the presence of C-kinase has not been reported. In this paper we reported for the first time the purification of C-kinase from rat placental chorion and investigated the physiological functions of C-kinase. The results were as follows: A considerable amount of C-kinase was detected in the membrane fraction of rat placenta. C-kinase specifically phosphorylated several membrane proteins, and the phosphorylation pattern was different from those of mid pregnancy and late pregnancy. The C-kinase activity in late pregnancy was 6 times higher than that of mid pregnancy. Hemin and Polylysine inhibited partially-purified membrane-bound C-kinase. Substrate specificity C-kinase from rat placenta was similar to those from other organs.

Animals↗
PubMed1986

Nonfamilial prealbumin-type amyloid polyneuropathy.

A 53-year-old man with nonfamilial prealbumin-type amyloid polyneuropathy had severe motor, sensory, and autonomic polyneuropathy, beginning at age 48 years. These clinical features closely resembled familial amyloid polyneuropathy (FAP), but abnormal serum prealbumin levels, specific to FAP (Japanese type), were not detected by radioimmunoassay; DNA sequence for prealbumin was normal. Thus, the diagnosis of FAP was excluded. A possible diagnosis of systemic senile amyloidosis was also considered.

Amyloidosis↗