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Biomedical subjects

H Fung

Publications and source records attributed to H Fung.

46 records · Page 3Linked to original sources
PubMed1987

Recurrent pancreatitis contributing to choledochal cyst formation.

We report three cases of choledochal cyst. The calibre of the common bile duct in each of them was demonstrated by ultrasonogram, CT scan, radiography and laparotomy to be almost normal before recurrent attacks of pancreatitis, following which the common bile duct was shown to become grossly dilated. This observation leads us to surmise that recurrent pancreatitis contributes to the formation of choledochal cysts.

Adult↗
PubMed1987

The effect of preoperative Lugol's iodine on thyroid blood flow in patients with Graves' hyperthyroidism.

A study was conducted to investigate the effect of Lugol's iodine on the superior thyroid artery (STA) blood flow with use of a Duplex ultrasound scanner for 12 patients with Graves' disease. All patients were treated with antithyroid drugs until they were euthyroid and then, with randomization, the patients received either Lugol's iodine, 0.3 ml thrice daily, or placebo for 9 days in a double-blind fashion. Antithyroid drugs were continued throughout the study. Reduction in the diameter, time-averaged velocity (TAV), and volume flow (VF) of the STAs was demonstrated in all patients in the treatment group, whereas there were no consistent trends in the placebo group. The changes in TAV and VF were significantly different between the placebo and treatment groups (p less than 0.01 for TAV and p less than 0.005 for VF). These changes were more marked in patients with high initial VF and minimal in patients with low initial VF. On the basis of these results, we recommend that patients with high thyroid blood flow before thyroidectomy should receive Lugol's iodine preoperatively.

Adult↗
PubMed1985

Adriamycin uptake, intracellular binding and cytotoxicity in Chinese hamster ovary cells.

The interaction between adriamycin influx, efflux and cytotoxicity has been studied in Chinese hamster ovary (CHO) cells. The rate of adriamycin uptake showed no evidence of saturation with increasing concentration suggesting that uptake occurred by passive diffusion. Plateau levels of adriamycin were reached within 20 min and more than 60% of this was firmly bound to the nucleus and did not efflux. Cytotoxicity studies did not correlate with uptake studies in that cell killing was an exponential function of drug exposure time well beyond the point at which intracellular concentrations had reached a maximum. This suggests that bound adriamycin is not primarily responsible for cytotoxicity.

Animals↗
PubMed1975

The myocardial effects of pancuronium.

The effect of pancuronium on myocardial contractility was studied in three different animal preparations. Pancuronium produced no change in isometric contraction of rabbit atrial or cat papillary muscle but displaced the acetylcholine dose-response curve to the right in the papillary muscle preparations, verifying a muscarinic blocking effect of this drug. In atropinized dogs in vivo pancuronium produced no significant change in the cardiovascular parameters studied. These studies show that pancuronium exerts its cardiovascular effects primarily by blocking muscarinic receptors in the heart.

Acetylcholine↗
PubMedDate not supplied

Transient post-partum thyroid dysfunction and postnatal depression.

In the course of a population study of thyroid dysfunction in pregnancy and the post-partum period, 65 women, considered to be antibody-positive (microsomal and thyroglobulin), and 82 antibody-negative women were assessed for postnatal depression at 6-8 weeks post partum. The women were also assessed for the development of post-partum thyroid dysfunction. Of the 147 women, 22 met DSM-III criteria for major depression. The presence of autoantibodies showed little association with depressed mood but there was a minor association of postnatal depression with actual thyroid dysfunction in that incidence of the latter condition was higher in depressed women (Raskin scale P less than 0.01; Edinburgh scale P less than 0.05; Montgomery-Asberg scale P less than 0.1). Three of eight mothers with thyroid dysfunction had major depression and were depressed on all three scales.

Adult↗