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Biomedical subjects

H Fukutomi

Publications and source records attributed to H Fukutomi.

At least 73 records · Page 4Linked to original sources
PubMed1990

Advanced carcinoma of the stomach treated with definitive proton therapy.

We report the case of a 72-yr-old man who suffered from severe chronic emphysema with poor pulmonary function, and who had advanced cancer of the stomach. Proton beam radiotherapy was applied to the lesion, since surgery was contraindicated. The total dose to the stomach lesion was 61 Gy in 7 wk. The tumor on the stomach regressed, with flattening of the round wall of the lesion. The reactive changes of the proton beam radiotherapy, based on the histopathological examination, revealed extensive tumor necrosis and sparing of vital architecture of normal tissue around the irradiated tumor tissue. Only small clusters of vital or devitalized tumor cells with less than approximately 5% of the whole tumor tissue remained after treatment. We suggest that a high dose of radiation delivered by well-defined proton field could result in an improved therapeutic outcome without undue risk of injury to normal tissue.

Adenocarcinoma↗
PubMed1990

[Combined treatment of esophageal small cell carcinoma with radiation and chemotherapy].

A 61-year-old male complaining of dysphagia and precordial chest pain was admitted to hospital. A series of upper G.I. examinations revealed an ulcerative tumor, approximately 8 cm in diameter, in the esophagus. A biopsy of a specimen led to the histological diagnosis of a small cell carcinoma (oat cell type). The cells were uniformly argentaffin-negative (Masson-Fontna) and many contained numerous tiny argyrophylic granules (Grimelius). Therefore, a combined therapy of radiation (70 Gy) and CDDP (total dose: 210 mg) was used to treat the lesion, and the disappearance of the mass shadow, as well as no narrowing of the esophagus, was noted without residual ulceration, indicating a complete response. Four months after the therapy, however, an extensive multiple liver metastasis occurred, and the patient died of hepatic and renal failure. His overall survival time was 7 months from start of the combined therapy. It thus is felt that a multi-drug regimen and systemic chemotherapy are important in treating small cell carcinomas of the esophagus.

Carcinoma, Small Cell↗
PubMed1990

[A recurrent gastric carcinoma found by metastasis to the scrotum].

Reported is a case of 67-year-old man with a recurrent gastric carcinoma that was associated with a possible lymphatic metastasis to the scrotum. Seven years earlier (October, 1980), since an adenocarcinoma of the stomach was present, a subtotal gastrectomy was performed. At that time, a IIc-like advanced tumor with a ul-III, measuring 32 x 28 mm in size, was noted on the anterior wall of the corpus near the greater curvature of the stomach, on macroscopical examination of the resected specimen. Microscopic findings showed a poorly differentiated adenocarcinoma with an involvement of the serosa but without a lymph node metastasis (H0, P0, n0, se, stage III). In July 1987, a tumor in the right scrotum was found and the patient underwent surgery. The resected specimen revealed a histologically cancerous involvement of the testis, the epididymis, the tunica vaginalis testis, and the spermatic cord. The cancerous cells showed the same poorly differentiated adenocarcinoma which had been observed in the primary locus of the stomach. Judging from these findings, this case was diagnosed as a recurrent gastric carcinoma with a lymphatic metastasis to the scrotum.

Adenocarcinoma↗
PubMed1989

[A case of superficial esophageal cancer with an intramural metastasis to the gastric wall].

Reported is a case of 61-year-old man with a superficial esophageal cancer that was associated with an intramural metastasis to the stomach. Examination of the upper G.I. tract revealed a slightly elevated lesion with an irregular surface at the left wall of the lower esophagus, and a large submucosal tumor with an ulcerous formation that had developed and had increased rapidly within a month. Thus a resection of the lower esophagus and a total gastrectomy were performed. Histopathologically, the tumor of the lower esophagus was determined as being a moderately differentiated squamous cell carcinoma with a deep invasion to the submucosal tissue. The submucosal tumor of the stomach also was found to be a moderately differentiated squamous carcinoma. Neither provided evidence, however, of a direct involvement of the gastric serosa may have metastasized from the neighboring lymph nodes or from other organs, nor of any continuous mucosal metastasis between the primary lesion of the esophagus and the submucosal tumor of the stomach. Judging from these findings, the case was diagnosed as an esophageal cancer with an intramural metastasis to the stomach.

Carcinoma, Squamous Cell↗
PubMed1989

[A case of superficial squamous cell carcinoma of the esophagus showing multicentric development].

A 43-year-old male was admitted to the hospital with a complaint of mild dysphagia. A barium esophagogram showed an annular narrowing in the lower esophagus. Further, an endoscopic examination revealed erosive mucosa of the esophagus about 35 cm anal to the incisor. Lugol staining also revealed a geographical unstained lesion. The histologic diagnosis of a biopsy specimen indicated a squamous cell carcinoma and a total resection of the esophagus was performed. The operated material macroscopically showed a tumor of a superficially mixed type (IIa + IIc + IIb). The resected specimen histologically consisted of 18 squamous carcinomas that were separated with the normal squamous epithelium from each other. The major part of these lesions were limited to the epithelium, and only a few specimens microscopically showed an invasion of cancer nests in the propria mucosae. Great permeation of cancer cells into lymph vessels and the metastasis of one regional lymph node also were noted. Taken together, these findings indicated that the squamous cell carcinomas of this case seemed to have multicentrically developed from the normal esophageal mucosa.

Adult↗
PubMed1988

[A case of leiomyosarcoma of the stomach treated effectively by tegafur and absolute curative resection].

A 51-year-old woman with leiomyosarcoma of the stomach treated effectively with FT 600 mg/day p.o., is reported. Leiomyosarcoma of the stomach was found in the greater curvature on the fornix by examinations involving X-ray and gastrofiberscopy with biopsy. She was subsequently treated with MMC 6 mg/2 alpha/w x 5 weeks and FT 600 mg/day continuously on account of liver metastasis determined by liver scintigram and CT. After one year, both gastrofiberscopy and X-ray pictures showed a decrease in the size of the SMT. An evaluation of the treatment showed partial response (PR), and the state of PR was maintained for more than 5 years. Six years and 9 months after chemotherapy, however, unresponsiveness to the therapy appeared and regrowth of the SMT followed. Furthermore, intrahepatic SOL was definitely diagnosed to be cavernous hemangioma of the liver. Consequently, proximal gastrectomy was performed using R1-absolute curative resection, after confirming that the histology of the SMT was leiomyosarcoma of the stomach by endoscopic partial tumorectomy.

Combined Modality Therapy↗
PubMed1988

[An autopsy case of esophageal cancer with brain metastasis].

A rare case of esophageal cancer with brain metastasis is reported. A 54-year-old man complaining of dysphagia was admitted to our hospital. Endoscopic and radiographic examinations revealed an advanced esophageal cancer with supraclavicular lymph node metastasis. Five months later, muscle weakness of right upper extremities developed. A brain CT scan revealed a low density area with a ring enhancement in the left front parietal region. The patient developed right hemiplegia and delirium, and died seven months later. Autopsy findings showed a hematogenous metastasis of the left precentral gyrus, measuring 3.0 x 2.5 x 2.5 cm.

Brain Neoplasms↗
PubMed1988

[Megacolon].

Explore the source record for details and available documents.

Adult↗
PubMed1988

[Endoscopic therapy of gastrointestinal cancer and its curability].

Endoscopic laser therapy was applied to the patients with early gastric cancer in surgically high risk. Results were as follow. (1) 31 lesions of 23 patients with early gastric cancer were treated by endoscopic Nd-YAG laser irradiation. About 76% of lesions were removed completely. (2) The laser therapy was effective in the cases of elevated type, small type, mucosal type and well differentiated type of the early gastric cancer. (3) According to statistical study of early gastric cancer operated in Japan, metastasis to regional lymph-node occurred in 4% of mucosal cancer. But lymph-nodes metastasis could not be found in the cases of pedunculated protruded type early cancer, II a type mucosal cancer smaller than 1cm, and II c type well differentiated adenocarcinoma limited to the mucosal layer with no ulceration. (4) There was no major complication in our therapy. Endoscopic Nd YAG laser therapy seems to become one of the therapeutic choice for small early gastric cancer (m) in elderly or critically ill patients.

Gastroscopy↗
PubMed1987

Famotidine: postmarketing clinical experience.

A postmarketing survey of famotidine usage (phase IV survey) tracked 6346 patients at 602 locations from August 1985 to April 1986. Through the survey, the efficacy and the safety of famotidine were studied. The patients included 4618 cases of peptic ulcer, 106 cases of reflux esophagitis, 1006 cases of upper gastrointestinal tract bleeding, 343 cases of bleeding and ulcer prophylaxis, and 273 cases of gastritis and other diseases, totalling 6346 patients. Efficacy was analyzed by type of disease in terms of overall improvement; results of intermittent hemostatic efficacy were obtained for upper gastrointestinal tract bleeding; and safety was assessed. Overall, the results were good; the 8-week healing rate was 92.4%, and 72.3% of patients had their bleeding controlled within 7 days of beginning famotidine therapy. Side effects occurred in only 0.43% of patients, and abnormalities in laboratory test results were observed in less than 1% of patients. Gastrointestinal side effects, especially constipation, occurred most frequently. Most side effects were mild. The results of this postmarketing survey indicate that famotidine is a safe and effective H2-receptor antagonist.

Adult↗
PubMed1987

[An autopsy case of AFP-producing gastric carcinoma resembling hepatocellular carcinoma on light microscopy].

We experienced an autopsy case of alpha-fetoprotein(AFP)-producing advanced gastric carcinoma with liver metastasis. Microscopically, the tumor was compose by medullary nests of poorly differentiated adenocarcinoma cells. The cells had an exclusively hepatoid pattern characterized by discrete masses, nests, and broad bands, consisting of large eosinophilic epithelial cells and separated by fibrous stroma. Immunohistochemical studies of hepatoid cells yielded a positive reaction for AFP, but negative for CEA. Electron microscopically, tumor cells possess a ductal lumina with abundant microvilli having a central core filaments, and secretory granules in cytoplasma. These findings suggest that the tumor cells differentiated into intestinal direction, irrespective of the appearance of their hepatoid features characterized by light microscopy.

Adenocarcinoma↗
PubMed1987

Efficacy of sucralfate in the prevention of recurrence of peptic ulcer--double blind multicenter study with cimetidine.

A double blind, multicenter, six-month maintenance study was performed to assess the efficacy and safety of sucralfate (S), cimetidine (C), and their combination (S + C) in the prevention of peptic ulcer recurrence in a six-month observation period. 127 patients with gastric ulcer (GU) (group S: 39, group S + C: 48, group C:40) and 103 patients with duodenal ulcer (DU) (group S: 35, group S + C: 36, group C:32) were available for statistical analysis. Six to 12 months after healing of GU, the cumulative recurrence prevention rates by Kaplan-Meier method were 89.7----80.3% in group S, 97.6----72.6% in group S + C, 84.5----44.6% in group C. In duodenal ulcer they were 75.9----41.9% in group S, 87.8----47.7% in group S + C, 80.8----40.5% in group C. These results indicate that maintenance therapies of S and S + C are effective and safe for the prevention of gastric ulcer recurrence.

Adult↗
PubMed1987

[A case of five cancerous lesions of the colon diagnosed by preoperative examination].

A rare case of five synchronous colon cancers has been reported. A 52-year-old woman was admitted to our hospital complaining of pain at the right lower quadrant. roentgenographic and endoscopic studies of the colon revealed three cancerous lesions in the cecum the ascending colon, and two lesions at the sigmoid and rectosigmoid colon. Histopathological findings of the respective specimens showed one advanced cancer which had invaded into the muscuralis propria on the upper part of the Bauhin's valve, and four early type carcinomas invaded into the mucosa or submucosa. There were metastatic lesions at the regional lymph nodes in sigma, but distant metastatic lesions were not observed. These histologic findings suggest that these carcinomas had not arisen in preexisting benign adenomas, but had arose from normal mucosa (de novo cancer).

Adenocarcinoma↗