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Biomedical subjects

H Fukumoto

Publications and source records attributed to H Fukumoto.

At least 109 records · Page 6Linked to original sources
PubMed1988

[Arterial grafts for myocardial revascularization; experience of 65 internal mammary artery and gastroepiploic artery graftings].

From November, 1984, to February 1987, internal mammary artery (IMA) and gastroepiploic artery (GEA) graftings to coronary arteries were performed in 65 patients. Of these patients, 58 unilateral IMAs, 6 bilateral IMAs, 2 GEAs were utilized. The hospital mortality was 3.2% but no cardiogenic death occurred. Fifty-eight (89%) patients became asymptomatic after surgery. Postoperative angiography performed from 1 to 3 months after operation showed excellent patency in 57 (96%) IMAs and 2 (100%) GEAs. On the other hand, the patency of saphenous vein graft done at the same period were 88%. GEAs were used for 2 reoperated cases and revealed good patency and relief of symptoms without surgical complication. Cavitron ultrasonic surgical aspirator (CUSA) was used to dissect IMA from the chest wall, which was useful to shorten the operative time. In conclusion, arterial grafts, such as IMA and GEA were thought to be excellent coronary bypass conduits even for the small Japanese patient.

Adult↗
PubMed1988

Internal mammary artery grafting in patients with smaller body structure.

The results of internal mammary artery grafting in 50 patients with a body surface area less than 1.6 m2 were compared with those in 54 patients with a larger body surface area. Age (58.8 +/- 8.2 versus 54.9 +/- 10.3 years old) and prevalence of female gender (28% versus 4%) were significantly different between the group of patients with a small body surface area and the group with a large body surface area, respectively. However, the prevalence of unstable angina, previous myocardial infarction, extent of coronary artery disease, and preoperative ejection fraction was not significantly different between the two groups. The mean number of distal anastomoses was 3.0 and 2.8, and the mean duration of aortic occlusion was 65.6 +/- 23.0 minutes and 59.5 +/- 21.7 minutes in the small and large body surface area groups, respectively (not significant). The mean free flow rate of the internal mammary artery was 65.6 +/- 16.8 ml/min in the small body surface area group and 78.0 +/- 21.6 ml/min in the large body surface area group (p less than 0.05). The diameters of the anterior descending and the circumflex arteries were significantly smaller in the small body surface area group. Two patients (4%) died within 30 days of operation and one patient died later in the small body surface area group, whereas no death was noted in the large body surface area group (not significant). No significant differences were found in the incidence of aortic balloon pumping, perioperative myocardial infarction, and serious postoperative complications between the two groups. Symptomatic relief was equally good in both groups (92% and 96%). The patency rate of the internal mammary artery was 95% (42/44) in the small body surface area group and 100% (48/48) in the large body surface area group within 1 year, mean 2.3 +/- 2.4 months. In conclusion, internal mammary artery grafting can be performed safely and effectively even in patients with small body structure. Though the blood flow of the internal mammary artery and the size of the coronary arteries were smaller in patients with small body structure, excellent patency of the internal mammary artery graft and satisfactory symptomatic relief can be expected.

Blood Flow Velocity↗
PubMed1987

Sequence of an intestinal cDNA encoding human motilin precursor.

A cDNA clone encoding the human motilin precursor was isolated from an intestinal library using synthetic oligonucleotide probes. The predicted amino acid sequence indicates that the motilin precursor consists of 115 amino acids and includes a 25-residue N-terminal signal peptide followed by the 22-amino-acid motilin sequence and a long, 68-residue C-terminal peptide. The amino acid sequence of human motilin predicted from the cDNA sequence is identical to its porcine counterpart, which has been determined by protein sequencing. Proteolytic processing of promotilin to motilin occurs at the sequence, Lys-Lys, this being the first reported instance of processing occurring at a pair of Lys residues. In other precursors it occurs at Lys-Arg, Arg-Arg, Arg, or very rarely Lys.

Amino Acid Sequence↗
PubMed1987

Effect of the alpha 2-blocker DG-5128 on insulin and somatostatin release from the isolated perfused rat pancreas.

2[2-(4.5-Dihydro-1H-imidazol-2-yl)-1-phenylethyl] pyridine dihydrochloride sesquihydrate (DG-5128) is an alpha 2-specific-adrenergic antagonist. We have studied the effect of DG-5128 on insulin and somatostatin release from the isolated perfused rat pancrease. DG-5128 stimulated somatostatin and insulin release not only at a low glucose concentration but also at a high glucose concentration. These findings suggest that an alpha 2-adrenergic receptor plays an important role in the regulation of insulin and somatostatin secretion.

Animals↗
PubMed1987

Application of ultrasonic aspirator for dissection of the internal mammary artery in coronary artery bypass grafting.

The low-power ultrasonic aspirator was used for the dissection of the internal mammary artery (IMA) in 20 patients undergoing coronary artery bypass grafting. Harvesting time was shorter and the amount of bleeding was less than with the ordinary method. The short-term patency rate (1 to 6 months) for those IMA grafts was 95% (19 of 20 remained patent). These results have encouraged us to use the ultrasonic aspirator routinely for IMA dissection.

Coronary Artery Bypass↗
PubMed1987

Coronary artery bypass grafting by utilizing in situ right gastroepiploic artery: basic study and clinical application.

The right gastroepiploic artery (GEA) was studied angiographically and histologically to determine its suitability for coronary artery bypass grafting. One hundred celiac angiograms demonstrated that the right GEA has the appropriate size (diameter less than 1.5 mm, 4%; 1.5 to 2 mm, 29%; more than 2 mm, 67%) and length (less than half of the greater curvature, 5%; more than half of the greater curvature, 95%; more than two-thirds of the greater curvature, 34%) for use as an in situ graft. A stenotic lesion of a GEA was observed in only 1 angiogram. Histological examination of a right GEA from 5 patients who had undergone gastrectomy demonstrated no evidence of arteriosclerosis. Encouraged by these results, we performed a coronary artery bypass reoperation utilizing an in situ right GEA graft in 2 women. Postoperative angiograms showed good patency of those grafts. The patients recovered well and were free from angina.

Adult↗
PubMed1987

Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.

Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum. The predicted amino acid sequence indicates that GIP is derived by proteolytic processing of a 153-residue precursor, preproGIP. The GIP moiety is flanked by polypeptide segments of 51 and 60 amino acids at its NH2 and COOH termini, respectively. The former includes a signal peptide of about 21 residues and an NH2-terminal propeptide of 30 amino acids. GIP is released from the precursor by processing at single arginine residues. There is a region of nine amino acids in the COOH-terminal propeptide of the GIP precursor that has partial homology with a portion of chromogranin A as well as pancreastatin.

Amino Acid Sequence↗
PubMed1987

Factors controlling induction of commitment of murine erythroleukemia (TSA8) cells to CFU-E (colony forming unit-erythroid).

On addition of DMSO, the MEL cell line TSA8 becomes committed into erythroid progenitor cells (CFU-E) which can form differentiated colonies in the presence of erythropoietin. To understand the mechanism of cellular commitment, the number and the affinity of the receptors for erythropoietin were estimated. The affinity of the receptors did not change before or after induction. The number of receptors changed depending on the growth phase, but was not dependent on the addition of the inducer. Thus, the presence of the receptors for erythropoietin may be required, but are not essential for responsiveness to erythropoietin. Further examination of the optimum conditions for commitment suggests that the concomitant actions of induced factor(s) with the receptors may control commitment of TSA8 cells to CFU-E.

Animals↗