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Biomedical subjects

H Fukaya

Publications and source records attributed to H Fukaya.

29 records · Page 2Linked to original sources
PubMed1981

Experimental and clinical studies on renal disturbance in obstructive jaundice.

Renal functions and the clinical courses of 14 patients with renal disturbances associated with obstructive jaundice were studied. All patients had high concentrations of serum bilirubin, long durations of jaundice and episodes of shock due to massive hemorrhage or severe inflammation. In an experimental study on jaundiced rats, effects of hypotension or bilateral renal artery occlusion on renal function and renal cortical mitochondrial respiration at 1 week, 3 or 6-weeks after biliary obstruction were investigated. In jaundiced rats, there was no remarkable difference in renal function, but the renal mitochondrial respiration indices decreased with prolongation of the biliary obstruction. In hypotensive rats with prolonged biliary obstruction, the mitochondrial function was impaired, and in the rats with renal artery occlusion, the mitochondrial impairment was more severe. Based on these clinical and experimental data, it is tentatively suggested that patients with prolonged jaundice should be considered in a prodromal state of renal failure and that any minute circulatory failure may induce acute renal failure.

Acute Kidney Injury↗
PubMed1969

Simple uniaxial and uniform biaxial deformation of nearly isotropic incompressible tissues.

A method is developed for analyzing in a unified manner both uniaxial and uniform biaxial strain data obtained from nearly isotropic tissues. The formulation is a direct application of nonlinear elasticity theory pertaining to large deformations. The general relation between Eulerian stress (sigma) and extension ratio (lambda) in soft isotropic elastic bodies undergoing uniform deformation takes the simple form: sigma = ((lambda(3) - 1)/lambda) f(lambda), where f(lambda) must be determined for each material. The extension ratio may be either greater than 1.0 (uniaxial elongation), or lie between zero and 1.0 (uniform biaxial extension). Simple analytical functions for f(lambda) are most readily found for each tissue by plotting all data as (lambda(3) - 1)/lambdasigma vs. lambda. Of those tissues investigated in this way (dog pericardium and pleura, and cat mesentery and dura), all but pleura could be adequately described by a parabola: 1/f(lambda) = 1/k{[(lambda(M) - lambda)(lambda - lambda(m))]/[lambda(M) - lambda(m)}. In these instances, three material constants per tissue (K, lambda(M), lambda(m)) served to predict approximately the stresses attained during both small and large deformations, in strips and sheets alike. It was further found that the uniaxial strain asymptote (lambda(M)) was linearly related to the biaxial strain asymptote (Lambda(M)), thus effectively reducing the number of constants by one.

Animals↗