Biomedical subjects

H Frydman

Publications and source records attributed to H Frydman.

3 recordsLinked to original sources

PubMed1995

Semiparametric estimation in a three-state duration-dependent Markov model from interval-censored observations with application to AIDS data.

The semiparametric maximum likelihood estimation is considered in a three-state duration dependent Markov process when times of the intermediate transition (e.g., onset of a disease) are interval censored and the times of transitions to an absorbing state (e.g., death) are known exactly or are right censored. It is assumed that the intensity of the transition to an absorbing state depends both on chronological time and duration in the intermediate state. De Gruttola and Lagakos (1989, Biometrics 45, 1-11) and Frydman (1992, Journal of the Royal Statistical Society, Series B 54, 853-866) discussed non-parametric estimation from the same sampling scheme under the assumption that the intensity of transition to an absorbing state depends only on the duration in the intermediate state or only on the chronological time respectively. The approach taken here generalizes, but in discrete time framework, the results from Frydman (1992). The distribution of the time to the intermediate transition is modelled nonparametrically and the intensity of onset of terminal condition semiparametrically. The algorithm is developed for the computation of the estimators. The methods are illustrated with AIDS data.

Acquired Immunodeficiency Syndrome↗

PubMed1990

Malignant melanoma. Changing trends in factors influencing metastasis-free survival from 1964 to 1982.

Seven hundred fourteen patients with cutaneous melanoma in clinical Stage I treated between 1964 and 1982 were included in this study. In an analysis of metastasis-free survival, thickness of the tumor, ulceration, gender, epithelioid cells as predominant cells in the tumor, and localization of the tumor were found to be independent prognostic factors. In a time trends analysis, the distributions of three of the prognostic factors (thickness of the tumor, ulceration, and inflammatory cell infiltrate) were found to shift during the last decade in the direction of improved prognosis, indicating that tumors are detected earlier than before. The distributions of two other factors (cell type and location of the tumors) shifted in the direction of deteriorated prognosis, suggesting partly that the biologic nature of the disease may have changed and partly that other behavioral factors may have played a role.

Female↗

PubMed1985

Predicting outcome from hypoxic-ischemic coma.

Outcome from coma caused by cerebral hypoxia-ischemia (eg, cardiac arrest) was compared with serial neurological findings in 210 patients. Thirteen percent of patients regained independent function at some point during the first postarrest year. Computer application of new multivariate techniques to the prospectively observed findings generated easily utilized rules that classified patients by likely outcome. At the time of initial examination, 52 patients (one fourth of the total population) had absent pupillary light reflexes, and none of these patients ever regained independent daily function. By contrast, the initial presence of pupillary light reflexes, the development of spontaneous eye movements that were roving conjugate or better, and the findings of extensor, flexor, or withdrawal responses to pain identified a smaller group of 27 patients, 11 (41%) of whom regained independence in their daily lives. By 24 hours after onset, 93 poor-outcome patients were identified by motor responses that were absent, extensor, or flexor and by spontaneous eye movements that were neither orienting nor roving conjugate; only one regained independent function. This contrasts with recovery in 19 (63%) of 30 patients who at that time showed improvement in their eye-opening responses and obeyed commands or had motor responses that were withdrawal or localizing. Similarly simple rules distinguished between good- and poor-prognosis patients on postarrest days 3, 7, and 14.

Adult↗