Biomedical subjects

H Fruhstorfer

Publications and source records attributed to H Fruhstorfer.

At least 37 records · Page 2Linked to original sources

PubMed1978

[Comparative studies of the local anaesthetic action of carticaine 1% and mepivacaine 1% (author's transl)].

The actions of carticaine 1% and mepivacaine 1% in peripheral nerve block were investigated in double-blind study. Bilateral ulnar nerve blocks were performed in 14 healthy subjects (age range 20-30 years), and latency, duration, and intensity of anaesthesia were quantitatively determined. There were no differences in latency of nerve block, but a significant difference in the duration of effect: Mepivacaine acted for nearly twice as long as Carticaine. In addition, several incomplete blocks were noted with Carticaine. On the basis of these results mepivacaine is preferred in peripheral nerve block because of its longer and more reliable action.

Adult↗

PubMed1976

Method for quantitative estimation of thermal thresholds in patients.

A quantitative method for the examination of thermal sensibility was applied in 26 normal subjects and in patients with various neurological disorders. The stimulation technique resembled Békésy audiometry: the patient reversed the direction of the temperature change of a thermode whenever warm, cold, or thermal pain thresholds were reached. The resulting temperature curve enables a quantitative description of the subject's thermal sensibility and of the degree of impairment displayed by neurological patients.

Abdomen↗

PubMed1975

A comparative study between etidocaine and bupivacaine in ulnar nerve block.

The long-acting local anaesthetics bupivacaine and etidocaine were compared in a double-blind study using ulnar nerve block. Eleven volunteers took part in the study. Solutions used were: bupivacaine 0.25% and 0.5% and etidocaine 0.5% and 1 %. All solutions contained adrenaline 5 mug/ml. The time of onset and duration of analgesia and motor block, degree of motor block, and changes in skin temperature were investigated. The results did not show any differences in the duration of sensory of motor block. Differences were seen in the degree of motor block in favour of etidocaine. The sympathetic block seemed to be more intense and of longer duration with bupivacaine. Etidocaine had a shorter time of onset in all nerve fibres.

Acetanilides↗

PubMed1975

Brachial plexus blockade for evaluation of local anaesthetic agents.

Brachial plexus block (axillary approach) has been compared with ulnar nerve block for the evaluation of local anaesthetic drugs. Duration of analgesia is the same in both techniques with the same drugs. Following axillary nerve block the median, ulnar and radial nerves are blocked for a different time. The onset of motor block is faster following axillary nerve block, according to muscle power, but not according to action potentials in the e.m.g. Once all the nerves are blocked, no differences exist for the duration of muscle paralysis. The rate of techinical failure is higher with brachial plexus blocks compared with single nerve blocks. Larger amounts of local anaesthetic solutions are necessary for plexus blockade and this may cause toxic effects. The volunteer's comfort is less after plexus block because of more widespread paralysis. Therefore, ulnar nerve block and extradural block are in many respects the most suitable techniques for evaluation of new local anaesthetic agents.

Action Potentials↗

PubMed1975

[Axillary plexus block with long-acting local anaesthetics (a comparative study of etidocaine and bupivacaine) (author's transl)].

Brachial and axillary plexus blockade was carried out on volunteers using a mixture of etidocaine 1% with adrenaline, and bupivacine 0,5% with adrenaline. Both drugs are long-acting local anaesthetics. No difference has been established with regard to duration of analgesia and motor nerve block. Blockade of sympathetic nerve fibres lasts significantly longer with bupivacaine than with etidocaine. With the latter motor blockade seems to be more strongly influenced and significantly outlasts sensory sympathetic nerve block. The results and findings of other authors are discussed, and whether the different behaviour of the 2 long acting local anaesthetics in this context implies a different affinity of the drugs to the different types of nerves.

Acetanilides↗

PubMed1974