Search PubMed⌕ Search

Biomedical subjects

H Fritzsche

Publications and source records attributed to H Fritzsche.

131 records · Page 8Linked to original sources
PubMedDate not supplied

[Mixed connective tissue disease. Clinical studies on a new group of collagenoses].

The clinical features of 6 patients with symptoms of various connective tissue diseases and rheumatoid arthritis are reported. The frequency of symptoms corresponded to that of the syndrome, which Sharp et al. (1971) termed mixed connective tissue disease. The antibodies to an extractable nuclear antigen are a characteristic feature. Moreover, one may detect a speckled staining pattern by indirect immunofluorescence. In addition, moderate immunoglobulin deposits were observed in the skin and kidneys of our patients. The pathomechanism of these deposits is discussed.

Adult↗
PubMedDate not supplied

[Effect of DNA local conformation on the affinity and binding specificity of bis-netropsins to DNA].

The interaction of short nucleotide duplexes with bis-netropsins, in which netropsin fragments are linked in the tail-to-tail orientation via cis-diammineplatinum group (<--Nt-Pt(NH3)-Nt-->) or aliphatic pentamethylene chain (<--Nt-(CH2)5-Nt-->), has been studied. Both the bis-netropsins have been shown to bind to DNA oligomer 5'-CCTATATCC-3' (I) as a hairpin with parallel orientation of netropsin fragments in 1:1 stoichiometry. Monodentate binding has been detected upon binding of bis-netropsins to other duplexes of sequences 5'-CCXCC-3'--where X = TTATT (II), TTAAT (III), TTTTT (IV), and AATTT (V)--along with the binding of bis-netropsins as a hairpin. The formation of dimeric antiparallel motif between the halves of two bound bis-netropsin molecules has been observed in the complexes of <--Nt-(CH2)5-Nt--> with DNA oligomers IV and V. The ratio of binding constant of bis-netropsin as a hairpin (K2) to monodentate binding constant (K1) has been shown to correlate with the width and/or conformational lability of DNA in the binding site. The share of bis-netropsin bound as a hairpin decreases in the order: TATAT > TTATT > TTAAT > TTTTT > AATTT, whereas the contribution of monodentate binding rises. The minimal strong binding site for <--Nt-Pt(NH3)-Nt--> and <--Nt-(CH2)5-Nt--> binding as a hairpin has been found to be DNA duplex 5'-CGTATACG-3'.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Placental circulation in simultaneous beta-stimulation using hexoprenaline and beta-1 blockade with celiprolol].

In a therapy with Hexoprenalin 0.3 microgram/min an additional administration of Celiprolol (3 X 100 micrograms oral) or Placebo did not change significantly the Placenta perfusion. It remains a question, if an additional therapy with beta 1-mimetic agents is necessary, since Hexoprenalin alone did not change the cardiovascular parameters significantly. This results are not transferable to altered dose or to different betamimetic- and beta blocking agents.

Adult↗