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Biomedical subjects

H Friedman

Publications and source records attributed to H Friedman.

At least 559 records · Page 31Linked to original sources
PubMed1970

Vibriolytic antibody-forming cells: a new application of the Pfeiffer phenomenon.

Complement-mediated immune lysis was first described by Pfeiffer after observing an immune reaction against Vibrio cholerae. Application of this reaction in agar gel, with viable vibro organisms, gave results which were unique compared to the red blood cell or enterobacterial systems. Among these was the lack of a detectable "background," a lengthened latent period and differentiable results among the three major cell wall antigens characteristic of this bacterial groups.

Animals↗
PubMed1970

L-asparaginase-induced immunosuppression: effects on antibody-forming cells and serum titers.

Treatment of mice with L-asparaginase from Escherichia coli resulted in a marked suppression of the immune response, as assessed both cellularly and humorally. Suppression occurred only when the enzyme was injected together with the sheep erythrocytes used as antigen. There was little or no effect when the enzyme was injected before the antigen. Simultaneous injection of asparagine prevented suppression, an indication that the effect of the enzyme was due to depletion of an amino acid probably essential for normal lymphoid cell function during antibody production.

Animals↗