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Biomedical subjects

H Fox

Publications and source records attributed to H Fox.

At least 145 records · Page 8Linked to original sources
PubMed1985

The prognostic value of morphometry in ovarian epithelial tumors of borderline malignancy.

A fully "blind" morphometric analysis was made of 20 ovarian epithelial tumors; 18 of these were of borderline malignancy, one was a well-differentiated adenocarcinoma and one had been categorized as "borderline? malignant?" Morphometry correctly identified the adenocarcinoma, which had proved fatal, and the two tumors of borderline malignancy that had directly led to the patients' deaths, as having a "poor" prognosis. One tumor thought to have a "poor" prognosis was associated with long-term survival, but the patient had received chemotherapy. All the patients whose tumors were morphometrically graded as having a "good" prognosis were alive and tumor-free at intervals ranging from 4 to 14 years. It is concluded that the predictive prognostic power of morphometry, when applied to ovarian epithelial tumors of borderline malignancy, is greater than that of unaided light microscopy.

Adenocarcinoma, Mucinous↗
PubMed1985

The pathology of tampon usage and of the toxic shock syndrome.

Tampon usage is commonly associated with the development of transient, asymptomatic focal vaginal abnormalities such as dehydration, epithelial peeling and micro-ulceration. These abnormalities occur most commonly with superabsorbent tampons and are probably due to a fluid shift across the vaginal epithelium. Clinically apparent vaginal ulceration due to tampon usage is rare: these ulcers may develop from asymptomatic tampon-induced micro-ulcers. The pathological changes seen in the toxic shock syndrome are inconsistent but are, in general, due either to reduced tissue perfusion, or to the effects of a toxin. Cervico-vaginal ulceration in women with the toxic shock syndrome is probably a consequence rather than a cause of toxin entry into the systemic circulation.

Adult↗
PubMed1985

[Colorectal complications of radiological examinations].

These complications are uncommon, but can be very serious. They are dominated by perforations, in the case of barium enemas. The use of rigid canulas and/or balloons are often implicated in rectal perforations which occur most readily in rectal tissue damaged by a biopsy. Colonic perforations usually occur in damaged tissues (various forms of colitis, cancer, colostomy). The hydrostatic pressure seems to be incriminated as a precipitating factor in the development of spasms in the presence of an underlying obstruction. The other complications are much less common. In children, perforation usually occurs during reduction of an intestinal intussusception. The complications of embolisation of the abdominal arteries consist of necrosis; the left colonic flexure is at greatest risk because of its blood supply. Emergency embolisation can be performed provided certain rules are respected.

Barium Sulfate↗
PubMed1984

Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma.

The authors have studied 17 cases of ovarian clear cell tumors having an adenofibromatous pattern and classified them on a histologic basis into three categories: benign, of low malignant potential, and associated with invasive clear cell carcinoma. Clear cell adenofibroma is characterized by orderly tubules and glands lined by uniform epithelium with little or no nuclear atypia set in an abundant stroma with an interlacing pattern resembling ovarian stroma. Clear cell adenofibromatous tumors of low malignant potential had a similar stroma, but exhibited moderate to marked degrees of epithelial proliferation and atypia. In the third category there were cases of invasive clear cell carcinoma in which a distinct portion of the tumor met the criteria for clear cell adenofibroma, or clear cell adenofibromatous tumor of low malignant potential. Cases of invasive clear cell carcinoma exhibiting a desmoplastic reaction or a diffuse fibrous stroma, but lacking typical adenofibromatous areas, were not included in this study. The benign and low malignant potential tumors showed no clinical evidence of aggressive behavior, whereas those associated with invasive clear cell carcinoma often did. Although there have been no recurrences in our small group of patients with tumors of low malignant potential, the histologic similarity of the epithelium in these tumors to that seen in invasive carcinomas justifies such a categorization. Further studies of larger series using the proposed classification should yield more information concerning the biologic behavior of these types of clear cell adenofibromatous tumors.

Adenocarcinoma↗
PubMed1984

Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes.

Fragments of the proximal half of mouse chromosome 17 including the t-complex region were microdissected from metaphase spreads. DNA was isolated from a pool of such fragments, and was cloned on microscale. Individual clones were used to probe genomic digests of DNA from a pair of Chinese hamster cell lines with or without mouse chromosome 17, and livers of congenic inbred lines of mice carrying wild-type and/or t-haplotype forms of chromosome 17. The data obtained indicate that 95% of the low copy number microclone inserts recognize DNA sequences present on mouse chromosome 17. It has been possible to use one-third of these clones to identify restriction-fragment-length polymorphisms between wild-type and t-haplotype DNA on a congenic background. These results demonstrate that these clones have been derived from the t-complex or regions closely linked to it. Clones of this type should provide starting points for a molecular analysis of this region of the mouse genome.

Animals↗
PubMed1984

Endometrial carcinogenesis and its relation to oestrogens.

The epidemiological evidence suggesting an association between the administration of exogenous oestrogens and an increased risk of developing endometrial adenocarcinoma is critically reviewed and it is concluded that the case for oestrogens being a cause of endometrial cancer is proven. The benefits flowing from preventing postmenopausal osteoporosis by oestrogen replacement therapy are assessed and contrasted with the danger to life posed by endometrial adenocarcinoma: it is pointed out that the type of neoplasm developing in patients taking oestrogens is well differentiated, nonaggressive and easily cured, the survival rate being very high. The addition of progestational agents to the therapeutic regime may prevent the development of endometrial carcinoma but could introduce a risk of cardiovascular disease.

Adenocarcinoma↗
PubMed1984

Absence of the aortic valve: antenatal and postnatal two-dimensional and Doppler echocardiographic features.

Antenatal and postnatal two-dimensional and gated pulsed Doppler echocardiography, beginning at 32 weeks' gestation, were used to evaluate the cardiovascular contribution to nonimmunologic hydrops in a gravida 1, para 0 nineteen year old woman. Antenatal two-dimensional imaging demonstrated a hypoplastic left heart variant of complete common atrioventricular (AV) canal. Antenatal gated pulsed Doppler examination of the fetal thoracoabdominal aorta revealed atypical pandiastolic retrograde flow. Postnatal noninvasive examination at 36 weeks' gestational age was unchanged from the prenatal study. Postmortem examination confirmed the noninvasive anatomic findings and revealed polysplenia. The mechanism of pandiastolic retrograde flow was attributable to "absence of the aortic valve," a previously unreported congenital cardiac anomaly, which resulted in severe antenatal and postnatal aortic regurgitation.

Abnormalities, Multiple↗
PubMed1984

The expression of Ca antigen in normal, hyperplastic and neoplastic endometrium.

The expression of Ca antigen in normal, hyperplastic and neoplastic endometria has been studied by an immunoperoxidase technique. Ca antigen was frequently detectable in normal secretory endometrium, was found only rarely in cystic glandular hyperplasia or hyperplasia with architectural atypia, was expressed with moderate frequency in hyperplasia with cytological atypia and was invariably present in endometrial adenocarcinoma. It is concluded that the Ca antigen is of no discriminatory value in differentiating between hyperplastic and neoplastic conditions of the endometrium.

Adenocarcinoma↗
PubMed1984

A study of the Ca antigen in epithelial tumours of the ovary.

The expression of Ca antigen in ovarian epithelial tumours has been studied by an immunohistochemical technique using the Ca 1 monoclonal antibody. The antigen was found to be present in some examples of each of the histological subtypes of ovarian epithelial neoplasms and was detected in benign, borderline and malignant tumours. It is concluded that the presence of Ca antigen is of no discriminatory value in the assessment of malignancy in ovarian epithelial neoplasms.

Adolescent↗
PubMed1984

Vulvar intraepithelial neoplasia and microinvasive carcinoma of the vulva.

The pathological, cytological, and clinical features of vulvar intraepithelial neoplasia (VIN) are described. The rate of progression of VIN III to an invasive carcinoma is very low and spontaneous regression can occur. These features prevent the drawing of a direct analogy between vulvar and cervical intraepithelial neoplasia. The concept of microinvasive carcinoma of the vulva is discussed, and it is concluded that no satisfactory definition of this entity has been achieved.

Adult↗
PubMed1984

Argyrophil cells in normal, hyperplastic, and neoplastic endometrium.

Scanty argyrophil cells are present in a substantial proportion of normal endometria, particularly during the secretory stage of the cycle. Argyrophil cells are also present in the various types of hyperplastic endometria and are found in more than half of endometrial adenocarcinomas. In some endometrial neoplasms they are present in abundance, but tumours rich in such cells do not have any features suggestive of a carcinoid tumour and are morphologically identical to adenocarcinomas of similar grade which are devoid of argyrophil cells. Endometrial adenocarcinomas containing argyrophil cells tend to be well differentiated and tend not to invade deeply into the myometrium. It is suggested that Müllerian epithelial stem cells possess a potentiality for differentiation into APUD cells.

Adenocarcinoma↗
PubMed1984

Pelvic endometriosis and tubal inflammatory disease.

The incidence of tubal inflammatory disease in women with endometriosis who had undergone surgery was compared with that in women who had undergone similar operative procedures but who did not have endometriosis and with that in a group of clinically healthy women undergoing tubal sterilisation. The incidence of tubal inflammatory lesions was much higher in all women who had undergone surgery than in those undergoing sterilisation, but there was no difference in the incidence of tubal lesions between those women with endometriosis and those not suffering from this disease. Women with endometriosis and tubal inflammatory disease did not have a significantly lower mean gravidity than did those with healthy tubes. It is concluded that there is no specific association between endometriosis and tubal inflammation and that tubal inflammatory disease is unlikely to be a significant factor contributing to infertility in endometriosis.

Endometriosis↗
PubMed1984

Effects of talc on the rat ovary.

Exposure of rat ovaries to talc was accomplished by intrabursal injection. As early as 1 and up to 18 months after treatment, the ovaries and associated tissue were cystic in appearance; these changes were the result of bursal distention. Histologically the ovarian tissue was decreased in amount and spread as a remnant on the inner wall of the bursa. In four to 10 treated animals but in no controls, focal areas of papillary change were noted in the surface epithelium of the ovary. Polarized light and electron microscope microanalysis confirmed the presence of talc in the surface epithelium, ovarian cortex, and connective tissue matrix of the bursa. Although the changes in the ovarian surface may be related to direct effects of talc exposure, it is postulated that these changes might also be related to constant exposure to the high concentrations of steroid hormones which have undoubtedly accumulated in the intrabursal space.

Animals↗