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Biomedical subjects

H Fox

Publications and source records attributed to H Fox.

At least 307 records · Page 17Linked to original sources
PubMed1966

Haemangiomata of the placenta.

A series of six placental haemangiomata is described. Of these one was large and was associated clinically with hydramnios and premature labour. The remaining five were discovered in the course of a systemic examination of 500 unselected placentae. The literature on this tumour is reviewed and it is concluded that this is a very common lesion occurring in about 1% of all placentae. The tumour is probably hamartomatous in nature and is derived from primitive chorionic mesenchyme. Most tumours are small and intraplacental and are not associated with any clinical side effects. The comparatively small group of large haemangiomata do show an association with hydramnios, premature labour, low birth weight, foetal distress and, in a few instances, cardiomegaly in the infant.

Adolescent↗
PubMed1965

Primary malignant lymphoma of the uterus.

The clinical and pathological findings in a 59-year-old woman with a primary malignant lymphoma of the corpus uteri are described. There was a period of eight months between detection of the uterine lesion and evidence of disease elsewhere in the body. The patient died of disseminated lymphoma, and the distribution of secondary deposits were suggestive of spread via the right ovarian-uterine venous system.The criteria for acceptance of a diagnosis of primary uterine lymphoma are discussed and the previous literature is reviewed. There have been nine acceptable cases of primary uterine lymphoma recorded: four in the corpus uteri and five in the cervix. The differential diagnosis from stromal sarcoma, anaplastic endometrial adenocarcinoma, leiomyosarcoma, and benign lymphoid hyperplasia is discussed.

Female↗
PubMedDate not supplied

Current topic: trophoblastic pathology.

Selected topics in trophoblastic pathology which are arousing current interest are briefly reviewed. These include the concept of villitis as a non-specific immunological lesion, changing views on the distinction between partial and complete hydatidiform mole, a reconsideration of the role of inadequate placentation in pregnancy hypertension and in spontaneous abortion, the significance of confined placental mosaicism and the importance of infection and defective collagen synthesis in premature rupture of the membranes.

Chorionic Villi↗
PubMedDate not supplied

The local immunological defence system of the human endometrium.

The distribution of immunoglobulins and secretory component (SC) in the human endometrium has been studied by an immunoperoxidase technique. SC is present in a proportion of the epithelial cells and the amount of this substance is increased during the secretory phase of the cycle. A variety of immunoglobulins are present, in low concentrations, in the stromal interstitium during the secretory phase of the cycle and these are thought to diffuse passively from the plasma as a non-specific accompaniment of stomal oedema. Only IgA is found in the epithelial cells and this appears solely in those cells containing SC. No immunoglobuln-containing lymphoid cells are present in the endometrium. It is suggested that the endometrium lacks a true local secretory immune system but is able, because of its content of SC, to compensate for this by extracting polymeric IgA from the plasma. This system presumably helps to protect the endometrium against infection but the biological significance of its apparent control by progesterone is uncertain.

Animals↗
PubMedDate not supplied

Accelerated expression of Ca antigen by placental villous trophoblast in pre-eclampsia.

The Ca antigen is expressed by a range of normal tissues, as well as by many malignant neoplasms. The former includes placental villous syncytiotrophoblast where it appears first on syncytial sprouts at 20 weeks gestation, and progressively becomes more intensely and widely expressed on the surface of the trophoblast of villi of all sizes. We report here the prematurely intense expression of the antigen in pre-eclampsia (22 cases), by comparison with control sections from uncomplicated pregnancies. The expression of this antigen may have value as a relatively objective marker of accelerated maturation of the placental villous tree. It is suggested that the premature expression of Ca antigen in villous trophoblast in pre-eclampsia is due to external modification of a temporally related gene activation.

Antigens, Tumor-Associated, Carbohydrate↗
PubMedDate not supplied

An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia.

At the electronoptical level the placental villi of the pre-eclamptic woman are characterized by focal syncytial necrosis, loss and distortion of microvilli, dilatation of syncytial rough endoplasmic reticulum, decreased syncytial pinocytotic activity, a reduced number of syncytial secretory droplets, cytotrophoblastic hyperplasia, degeneration of occasional cytotrophoblastic cells, thickening of the trophoblastic basement membrane and the presence of small fetal capillaries with bulbous endothelial cells. Ultrahistochemical studies show reduced alkaline phosphatase and dehydrogenase activity in the syncytiotrophoblast but an increased acid phosphatase activity. It is suggested that all the observed morphological abnormalities, with the exception of cytotrophoblast cell degeneration, are explicable solely on the basis of utero-placental ischaemia and that no other aetiological factor need be invoked: the cause of the cytotrophoblast cell degeneration is, however, unknown. The ultrastructural findings indicate that there is a decrease in the transfer and synthetic activity of the trophoblast and that cellular respiration is also probably depressed. Nevertheless, there is some evidence that changes of a compensatory nature, designed to limit the effects of the tissue damage, are brought into play.

Acid Phosphatase↗
PubMedDate not supplied

An ultrastructural and ultrahistochemical study of the human placenta in maternal essential hypertension.

An electron-optical study of the placenta in essential hypertension indicates that the morphological changes seen in this disease are qualitatively very similar to those found in placentae from pre-eclamptic women: these changes are accentuated if pre-eclampsia is superimposed on essential hypertension. It is therefore suggested that the abnormalities seen in placentae from hypertensive women are due solely to ischaemia. The extent and degree of ischaemic damage suffered by the placenta is essential hypertension were, however, much less marked and extensive than in placentae from pre-eclamptic patients whilst in placentae from cases of essential hypertension complicated by pre-eclampsia there was less evidence of ischaemic damage than in placentae from cases of pre-eclampsia or comparable severity developing in previously normotensive women. It is suggested that the placenta is able to adapt to a state of chronic ischaemia in a manner that it is not able to do in late onset ischaemia and that the adaptive mechanisms adopted not only limit ischaemic damage but also afford protection to the placenta against the effects of superimposed pre-eclampsia.

Acid Phosphatase↗