Background variables and outpatient psychopathology.
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Demography↗
Biomedical subjects
H Ford
Publications and source records attributed to H Ford.
Titus Holliday Harris 1892-1969.
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History, 20th Century↗
Dr. Titus H. Haris retires as editor-in-chief.
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History of Medicine↗
Amino-acid uptake compared in motor neurons, spinal cord grey matter, muscle and liver.
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Amino Acids↗
Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template.
Adenosine deaminase (ADA) can discriminate between two distinct (North and South), conformationally rigid substrate conformers. (N)-methanocarba-2'dA (4) is deaminated 100 times faster than the antipodal (S)-methanocarba-2'dA (5), whereas a non-rigid analogue, aristeromycin (6), is deaminated at an intermediate rate. These results are in agreement with crystallographic data from ADA-ribonucleoside complexes showing the furanose ring of the bound purine in a C3'-endo (North) conformation. The data presented here suggests that 4 and 5 are useful probes to ascertain conformational preferences by purine metabolizing enzymes.
Adenosine Deaminase↗