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Biomedical subjects

H Fink

Publications and source records attributed to H Fink.

At least 109 records · Page 6Linked to original sources
PubMed1979

Psychotomimetics potentiate locomotor hyperactivity induced by dopaminergic drugs.

The spontaneous locomotor activity of rats was investigated in an open-field test. Apomorphine and d,1-amphetamine caused a dose dependent increase of locomotor activity. LSD, mescaline, and DMT in low doses were ineffective, when given alone, but caused a strong potentiation of the hypermotility induced by apomorphine and d,1-amphetamine. Cyproheptadine antagonized the potentiating effect of LSD without affecting the hypermotility induced by apomorphine, indicating a causal serotonergic involvement in the potentiation effect.

Amphetamine↗
PubMed1978

[Principles of controlled trials (author's transl)].

Wrong interpretations of the results of experimental trials on animals and of clinical studies block up scientific progress in medicine and withhold the best possible treatment from the patient. They are caused by concomitant influences independent of or dependent on treatment. Such bias is avoided only by designing "controlled trials". Their definition and principles are discussed here. In clinical drug research these principles can almost always be brought into concordance with the demands of medical ethics.

Animals↗
PubMed1978

[Effect of psychotomimetics and haloperidol on head twitching following alcohol withdrawal in mice].

After ethanol withdrawal dependent mice exhibited head twitching. The frequency of head-twitches was decreased by LSD and mescaline in a dose-dependent manner and increased by small doses of haloperidol and physostigmine. LSD antagonized the potentiating effects of haloperidol and physostigmine. The incidence of head-twitches after intracerebral injections of 5-HT in naive mice was lessened by LSD. The involvement of dopaminergic, serotoninergic, and cholinergic transmission systems in the action of psychotomimetics is discussed.

Animals↗
PubMed1978

Cerebral echinococcosis, a pediatric disease: report of two cases with one successful five-year follow-up.

Two cases of cerebral echinococcosis in children emphasize the need to consider the Echinococcus in the differential diagnosis of children with CNS signs and symptoms. One patient died because of delay in seeking medical attention. The other is now a 22-year-old college student with no evidence of recurrence more than five years after removal of Echinococcus cysts from both brain and liver. The newer modalities available for diagnosis are discussed. Therapy with mebendazole is reviewed; this relatively new, highly effective anthelmintic is well tolerated and has been apparently highly effective in a small number of cases.

Adolescent↗
PubMed1976

Carbohydrate metabolism of the lens depending on age.

Interpretation of factor analysis of 18 metabolic parameters of the bovine lens leads to the determination of the following criteria of lens metabolism: Factor 1: Biologic aging of the lens 33.9%; Factor 2: Glycolysis regulation 17.7%; Factor 3: Topography of lens metabolism 8.7%; Factor 4: Regulation of fructose breakdown 7.9%; Factor 5: Substrate depot 6.6%; Factor 6: Kinases 6.3%. These results could partly be experimentally verified. This interpretation of factor analysis has been an attempt to fit biochemical processes to formal statistical parameters. There was no indication that any of the variables under investigation were indendently responsible for the age dependend changes. However, the set-up made evident that rather complex biochemical influences of different intensity bring about the observed aging phenomena. It may be assumed that on or the other of these variables acts as a "triggering mechanism". Age related disturbances in the biochemical balance may be initiated by the glycolysis regulation factor, the importance of which is expressed by its high portion of 17%. Here changes in the ratio of reduced and oxydized coenzymes may act as a "triggering mechanism" (26, 30). Topography of lens metabolism, carbohydrate breakdown via metabolic pathways, the presence of substrate depots, and the internal regulation of the kinases are, according to their portion in factor loading, of about equal importance with respect to aging processes, however, factors 1 and 2, with a 50% portion, must be given precedence in any consideration. Factor 1, interpreted as "biological lens aging", yields about 1/3 of the information on the age influence on lens metabolism. This factor stands independent in being loaded by lens weight, which is the accepted age representative. However, lens weight means protein as well as the process of protein synthesis. It may be assumed that this factor represents a connective link between protein and carbohydrate metabolism, since it is well known that changes in protein belong to the most remarkable age disturbances (31,32), and that the quality of the proteins is dependent on the period of its synthesis (18,33).

Alanine Transaminase↗
PubMed1976

[The number of subjects or patients in clinical pharmacological studies].

A technique permitting without preliminary informations the assessment of the minimal number of test persons or patients to be studied in clinicopharmacological investigations dealing with multiple variables (vital functions, laboratory data) is reported. The procedure is applicable to investigations using data recorded at different time intervals and concomitant variables (basic values at the start of the investigation, age, and body weight). The minimal number of test persons or patients is estimated from the results of a formal examination. In this examination is tested whether a multivariate analysis of a therapeutic effect using all data only once and simultaneously is based on sufficient degrees of freedom of the error variance.

Clinical Trials as Topic↗
PubMed1975

Carbohydrate metabolism of the lens depending on age. V. Problems of mathematical approach and graphical presentation.

For investigations on age-dependent changes of lens metabolism, longitudinal studies are requisite. Graphic representation of such findings should be based on a proper arithmetic age scale. Using the lens weight for representing the age leads to distortion of the curves, whereby certain periods of life are liable to be overemphasized. In longitudinal studies, data on concentrations should never be given per unit weight, but rather for the whole lens. Absolute values of the whole, intact lens may be referred to a reference value, a percental representation of the curves is possible. With regard to the expectancy of life of test animals one may already state that longitudinal studies including the senile phase will only be feasible with rats.

Adenosine Triphosphate↗