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Biomedical subjects

H Fiedler

Publications and source records attributed to H Fiedler.

At least 73 records · Page 4Linked to original sources
PubMed1983

[Possible side effect of hormonal contraception: porphyria cutanea tarda].

The increased incidence of cases with porphyria cutanea tarda (p.c.T.) in women is correlated to preceding hormonal contraception. This is our reason to report on 16 females suffering from p.c.t. in the last years (1975 to 1979), including 8 females younger than 40 years affected after use of oral contraceptives for a long time. Stopping the hormonal anticonception represents the most important therapeutic measure. This is a good supposition to prevent recidives and to cure definitely. Cure is demonstrated in a young woman by normal pregnancy with a healthy boy.

Adult↗
PubMed1982

[Porphyria cutanea tarda or praematura as a symptom of the hepatotoxicity of hormonal contraception].

It is reported on an evident increase in female patients with porphyria cutanea tarda, seen in dermatological department of Halle/S. since 1975. Our female patients were much younger than patients with p.c.t. usually. 8 women, younger than 40 years in time of manifestation of disease have got contraceptive drugs for many years. Only one women under 40 didn't take contraceptive drugs, but she suffers from a thalassaemia minor. The combination of these diseases we have seen never before. P.c.t. as a follow of orale contraception should be included in calculations of the internal medicine, especially, if females suffer from preceding or coexisting hepatic failures.

Adult↗
PubMed1981

Course of serum-Ig concentrations in B12 chickens of the UM line.

The University of Munich chicken line ("UM") is isogenic in respect to the MHC and divides into normogammaglobulinemic, permanent and transient dysgammaglobulinemic individuals. Hence the immune defect is independent of the MHC. Continual analysis of the immunoglobulins until the 50th week of life revealed: one group of dysgammaglobulinemic individuals showed an initial IgG peak between the third and sixth week of life. Unusually high IgM and IgA levels occur in permanent and transient dysgammaglobulinemic individuals previous to the appearance of the IgG deficit and previous to a possible initial IgG peak. These high levels remain throughout the life of the chicken, possibly due to a missing negative feedback mechanism. Transient dysgammaglobulinemic chickens also exhibited increased IgM and IgA values after IgG normalization. Based upon our results, we postulate that the dysgammaglobulinemia defect is already preprogrammed during late embryonic development. The prevalence of a B or T-cell defect is still under discussion.

Animals↗
PubMed1981

Kinetics of delayed-type hypersensitivity (DTH) reactions and Ig levels in FCA-induced dysgammaglobulinemic B 12 chickens.

Kinetic studies on delayed-type hypersensitivity (DTH) to Freund's complete adjuvant (FCA) have been done in spontaneous dysgammaglobulinemic chickens, which have drastically reduced serum IgG levels and highly elevated IgM and IgA levels - in comparison to chickens with normal immunoglobulin (Ig) levels. For a period of five weeks, serum Ig levels, leukocyte migration inhibition (LMIT), and wattle reaction were examined once a week. In normal chickens, FCA treatment resulted in stimulation of IgG, but did not affect IgM synthesis, whereas in spontaneous dysgammaglobulinemic chickens, FCA stimulated only IgM synthesis. Spontaneous dysgammaglobulinemic chickens could produce LMIT and wattle reactions as well as normal birds. Whereas in normal birds, both types of DTH reactions declined continuously about the third or fourth week, in immunodeficient chickens, further increments of LMIT and wattle reactions up to the fifth week persisted as evidenced by LMIT and wattle reactions even 15 weeks after sensitization. In contrast, only minimal signs of reactivity were seen in normal birds. Spontaneous dysgammaglobulinemic chickens, nearly unable to synthesize IgG even after FCA stimulation in vivo, lack suppressive mechanisms regulating the course of DTH reaction to FCA. The possible B-cell nature of the regulatory cell population is discussed.

Animals↗
PubMed1980

[20 years of ulcerative colitis treatment. Retrospective study from the point of view of a medical clinic].

In the examined number of patients the ulcerous colitis played only a secondary role concerning the frequency. A decrease in the last five years could be explained by an improved ambulatory care. This clinical picture is, however, important on account of the inclination to recidivations and the acute complications. Of 93 patients 64 were coordinated to the degree of severity I, 16 to the degree of severity II and 13 to the degree of severity III. Particularly in patients who died of ulcerous colitis the clinical and paraclinical findings were not always parallel to the morphological changes. As a rule the treatment was performed by diet and azulfidines, only in 5 cases the application of prednisolone was necessary, 4 patients were operated. 11 patients died. Using the balanced enteral and parenteral nutrition, more severe stages of a disease will be better influenced and more favourable preoperative situations, respectively, will be reached also in older patients.

Adolescent↗
PubMed1980

[Liability for hepatitis after blood transfusion (author's transl)].

1) Only a very limited amount of all cases of so-called "post-transfusion-hepatitis" (pth) is really due to infectivity of the transfused blood. Regardless of the mostly unknown true source of the infection, the occurrence of "pth" for itself does not qualify the recipient and/or his illness-insurance company for a legitimate action for damages against the blood bank under current West Germany Federal Law. 2) All West German blood banks are obliged by Federal Law to insure themselves against strictly defined damage claims. Their damage-insurance companies are not entitled to pay compensations to the illness-insurance companies of any victim of "pth" without meticulous investigation of the exact circumstances if expenses exceeding the legally defined limitations are included in the premium of damage-insurance charged to the blood banks. 3)Since nearly all inhabitants of West Germany are legally or voluntarily insured against illness, compensations paid by damage-insurance companies to illness-insurance companies are no appropriate means for any cost containment of the latter: The blood banks have no other choice than to calculate the additional premium costs into the costs of the blood units to be debitted to the illness-insurance companies.

Blood Banks↗
PubMed1980

Establishment of a B-compatible chicken line with normogammaglobulinaemia and dysgammaglobulinaemia (IgM/IgG).

A dysgammaglobulinaemic line of chickens homozygous at the major histocompatibility complex has been established. In these chickens the IgG levels are decreased 10 to 100 times and IgM levels are increased 2 to 10 times when compared to those of normal birds. Dysgammaglobulinaemia is genetically determined. No linkage with the major histocompatibility complex of the chicken has been found.

ABO Blood-Group System↗