[Pseudomonas aeruginosa hospital infection in a pediatric unit. Typing by pyocine production].
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Age Factors↗
Biomedical subjects
H Fernandez
Publications and source records attributed to H Fernandez.
[Pharmacological treatment of ectopic pregnancy].
The incidence of ectopic pregnancies (EP), has increased significantly in the past 20 years. Conservative tubal surgery has long been the treatment of choice. However, non-surgical treatment of EP has recently become an alternative to surgery. This pharmacological approach uses chiefly methotrexate but attempts have been reported using prostaglandins, actinomycin D, potassium chloride, mifepristone and anti-hCG monoclonal antibodies. Early diagnosis and close follow-up of EP by methods including transabdominal and transvaginal ultrasound examination and serial measurements of hCG allow to choose the more appropriate treatment of EP. The present article gives an overview of the pathophysiology of EP, followed by a review of the various pharmacological treatments available. This review is centered on methotrexate as the best known drug in this indication. Published data on local and general tolerance, efficacy and pharmacokinetics are reviewed. A pretherapeutic assessment score using six criteria is also discussed, the objective of which is to better define the surgical and non-surgical indications. The non-surgical treatment of EP can provide a safe and effective alternative to surgical treatment. However, further studies are needed to assess the effects of these pharmacological treatments on both fertility and risk of recurrence of EP.
Female↗
[Precocious menopause after antimitotic therapy. Is in vitro fertilization with oocyte donation the only appropriate response?].
Advances in antimitotic treatments have improved the prognosis of cancer in young subjects. The resulting increase in life expectancy raises the question of the subject's future fertility, a question that should be posed before beginning any anticancer therapy which could lead to a gonadal failure. If oocyte donation remains the alternative indication proposed for these patients desiring a child, it is important to assess the tissue alterations in the uterus, to verify its vascularization under suitable treatment and appreciate the other alternative directions.
Antineoplastic Agents↗