Biomedical subjects
Publications and source records attributed to H Felix.
The data obtained from the anatomical study of the Fallopian canal, the intraoperative evoked electromyography and the histopathological evaluation of specimens from the greater petrosal nerve support the entrapment neuropathy concept in Bell's palsy.
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The authors present a general review of ten year evolution of the 7th pandemic of cholerae. They discuss the official data known from the country declarations. From the epidemiological features they distinguish a hydric dilution model of cholerae (few cases, few carriers, endemicity) and a direct inter-human contamination type (epidemic outbreaks, no endemicity).
Mefloquine (WR 142-490, RO 21.5998), and antimalarial 4-quinoleine-methanol, active on multiresistant strains of P. falciparum is a resourceful product because of its pharmacocinetics and the possibility it opens of a single day curative therapy. Its mean half-live is 15 days, with important individual variations from 8 to 23 days as well as racial one within North-American, Asiatic or African patients. A 1,25 to 1,50 g dose divided in 2 or 3 intakes during 16 hours has proved to be effective in 34 P. falciparum cases. Lower doses, near 1 g seem sufficient for P. vivax (6 cases) and P. ovale fits (4 cases). Clinical and biological acceptance are good, according to this limited study. The use of mefloquine might nowadays be reserved for geographical areas where resistance to P. falciparum is significantly high. Its diffusion in Africa, south of the Sahara, though conceivable, might be discarded for the time beeing.