Search PubMed⌕ Search

Biomedical subjects

H Feldmann

Publications and source records attributed to H Feldmann.

At least 181 records · Page 10Linked to original sources
PubMed1986

[Acute hearing loss in the early stage of acquired syphilis. A historical and a new case].

Acute hearing loss in an early stage of syphilis was frequently seen in the 19th century, but is very rare nowadays. One historical and one recent case of untreated syphilis are reported. Based on studies of the diary of the Czech composer Fr. Smetana the history of his disease is presented. Following an angina, which had lasted for several weeks, a profuse exanthema developed about 16 weeks after the primary infection. Two weeks later ear symptoms with hearing disorder, tinnitus and vertigo began, resulting in total bilateral deafness after some weeks. Exitus 10 years later by taboparalysis. The recent case is a 25 year old male subject. Also following a longstanding angina a profuse exanthema appeared about 8 weeks after the primary infection. Ear symptoms, hearing disorder and tinnitus in one ear, developed one week after onset of the exanthema. By immediate specific treatment a fateful cours like that of Smetana's could be prevented.

Adult↗
PubMed1985

Nucleotide sequence and characteristics of a Ty element from yeast.

We have determined the nucleotide sequence of a complete yeast Ty element (Ty-pY109) which is located near a tRNA(Lys1) gene. The element is 5912 bp in length; the internal domain is flanked by two identical delta sequences of 331 bp. Ty-pY109 contains two large open reading frames (ORFs) which overlap by 38 bp; the putative proteins consist of 440 and 1328 amino acid residues, respectively. The organisation of the coding sequences in Ty resembles that found in retroviral proviruses and the copia-like elements in Drosophila. Partial homologies have been found between Ty-ORF1 and tnpA from Tn3, and Ty-ORF2 and a reverse transcriptase-like domain (1,2).

Alleles↗
PubMed1985

Different patterns of transposable elements in the vicinity of tRNA genes in yeast: a possible clue to transcriptional modulation.

We have extended the catalogue of yeast tRNA genes that are found associated with repetitive (transposable) elements. We determined the nucleotide sequences of loci containing the genes for a tRNAGln and a tRNASer2 (pY66), a tRNAGlu3 (pY80), and a tRNALys1 (pY109). Our analyses revealed that complex patterns exist in which different types of elements (Ty, delta, sigma, and tau) are involved. We could further demonstrate that in several there are alleles of which one contains a particular element and the other lacks it; such differences are also found when comparing hybridization patterns of DNA from a diploid and a haploid yeast strain. In order to investigate a possible functional role of the elements in conjunction with the tRNA genes, we compared the transcriptional activities of several tRNA genes by microinjection into Xenopus oocyte nuclei. The observed differences in expression may be attributed to the presence or absence of different elements in the vicinity of the tRNA genes.

Alleles↗
PubMed1983

Development of diagnostic hearing tests.

Two different approaches in scientific research are outlined: (1) The basic approach focuses on the discovery of a basic phenomenon and follows the principles of induction and deduction. Practical application of the knowledge gained in this process is secondary. (2) The pragmatic approach starts from a practical problem and is based on experience. Theoretical explanation is secondary. After a discussion of these general principles, the development of some diagnostic hearing tests is presented in detail.

Audiology↗
PubMed1982

Ty1 and delta elements occur adjacent to several tRNA genes in yeast.

A comparative analysis of a number of yeast DNA-pBR322 recombinant plasmids carrying repetitive sequence elements has revealed that Ty1 or delta elements occur in the vicinity of several tRNA genes. Four examples have been characterized in detail: three glutamate tRNA genes and a serine tRNA gene. The tRNAGlu3 genes occupy different chromosomal locations; two of these genes are found adjacent to Ty1 elements, and the third is found adjacent to an independent delta element. A delta unit is also found adjacent to a tRNASer2 gene. Next to one of the tRNAGlu3 genes, the delta element is joined to a truncated sigma element. Junctions between different delta units were characterized by the sequence analysis of two DNA segments that carry no tRNA genes.

Base Sequence↗
PubMed1982

Nucleotide sequences of yeast genes for tRNA(2), tRNA(2) and tRNA(1): homology blocks occur in the vicinity of different tRNA genes.

Three members of a collection of pBR322-yeast DNA recombinant plasmids containing yeast tRNA genes have been analyzed and sequenced. Each plasmid carries a single tRNA gene: pY44, tRNA(2); pY41, tRNA(2); pY7, tRNA(1). All three genes are intronless and terminate in a cluster of Ts in the non-coding strand. The sequence information here and previously determined sequences allow an extensive comparison of the regions flanking several yeast tRNA genes. This analysis has revealed novel features in tRNA gene arrangement. Blocks of homology in the flanking regions were found between the tRNA genes of an isoacceptor family but, more interestingly, also between genes coding for tRNAs of different amino-acid specificities. Particularly, three examples are discussed in which sequence elements in the neighborhood of different tRNA genes have been conserved to a high degree and over long distances.

Journal Article↗
PubMed1982

[Tension pneumocephalus: a possible complication of posterior fossa craniotomy in the sitting position].

The authors describe a case of subdural tension pneumocephalus complicating the early postoperative course after posterior fossa craniotomy in the sitting position. This complication was promptly recognized and was treated successfully by allowing the compressed air to escape through frontal burr holes. A brief review of the recent literature is presented and the possible pathological mechanism is discussed. Emphasis is given to means of early detection and measures of prevention.

Child↗
PubMed1981

Sequence of a yeast DNA fragment containing a chromosomal replicator and a tRNA Glu 3 gene.

The sequence of a 1.9 kb Bam x Hind III fragment from yeast has been determined. This fragment is part of a yeast 6.7 kb Hind III segment cloned into pBR322 (pY20). The fragment carries a single gene for a glutamate tRNA which has no intron. According to genetic analyses [1] this fragment also contains a yeast chromosomal replicator. We have analyzed the sequence for potential open reading frames and for several structural features which are thought to be involved in the initiation of DNA replication. Hybridization studies have revealed that portions of this sequence are repeated within the yeast genome.

Base Sequence↗
PubMed1981

Structural comparison of two yeast tRNA Glu 3 genes.

DNA sequences in a 1.7 kb Pst fragment from yeast have been determined. This fragment is part of a yeast 7.4 kb Hind III segment cloned ino pBR322 (pY 5). The fragment carries a single gene for a glutamate tRNA. The coding portion of this gene is identical in sequence to that of the tRNA Glu 3 gene from pY 20 [1]. The flanking regions differ in their sequences, but possible secondary structures within the 5'-flanking regions bear similar features. Sequence homologies between pY 5 and pY 20 were detected far outside the tRNA genes. More surprisingly, extended sequence homologies were seen between the flanking regions of the pY 20 tRNA Glu 3 gene and a tRNA Ser gene [2,3]. We have also checked the known tRNA genes for structural similarities. Hybridization studies indicate that portions of the Pst fragment are repeated within the yeast genome.

Base Sequence↗
PubMed1981

Sudden hearing loss: a clinical survey.

After a brief statistic survey of general aspects the variety of clinical findings in sudden hearing loss is demonstrated by numerous observations. These illustrate the questionable role of supposed causes, the different modes of onset and course of sudden hearing loss, the audiometric findings and concomitant symptoms. The situation of both ears prior to the acute loss seems to be of great importance and offers a frame for classification, which is of clinical relevance. These features and others are discussed with regard to common theories on the etiology of sudden hearing loss. The difficulties in assessing therapeutic effects are pointed out considering the high rate of spontaneous recovery.

Adolescent↗
PubMed1981

[Refsum syndrome, heredopathia atactica polyneuritiformis in the view of the otolaryngologist (author's transl)].

An own observation of Refsum's disease is described. The female patient of 39 presented all characteristic symptoms of the disease, which had developed progressively starting at the age of 25: atypical retinitis pigmentosa with nightblindness and concentric constriction of the visual fields, cataracts, peripheral polyneuropathy with reduced nerve conduction velocity, ataxia, high protein level in CSF, ichthyosis-like cutaneous manifestations, sceletal anomalies, progressive sensorineural deafness, anosmia. Refsum's disease is a metabolic disorder based on an inborn enzyme defect, inherited by autosomal recessive transmission. It causes storage of phytanic acid in the body. Treatment consists in diet low in phytol and phytanic acid as well as large volume plasma exchanges.

Adult↗
PubMed1980

Structure of a yeast non-initiating methionine-tRNA gene.

4 to 8 kb Hind III fragments of yeast DNA were cloned into pBR322. One of these clones (pY6m3) containing a single tRNA3Met gene has been characterized in detail. The DNA sequence of the structural gene is colinear with the tRNA sequence, which means that in this case no intervening sequence is present. The 5'-leader and 3'-trailer sequences have also been determined. The 5'-flanking region can be folded up into possible secondary structures.

Base Sequence↗
PubMed1980

[Cervical root avulsion in metrizamide myelography].

Until now, the demonstration of cervical root pockets after root avulsion by means of the oily contrast medium Pantopaque has been considered to be the method of choice. Since Pantopaque usually cannot be completely tapped from the cerebrospinal fluid space and the authors have gained comprehensive and good experiences with the new water-soluble contrast medium Amipaque we have used this also for the demonstration of such empty root pockets. Technically, we have used the lateral cervical fluid space puncture between the first and the second cervical vertebra. The patient is placed in a lateral position, the pelvis slightly elevated and the head padded with a pillow. The cervical vertebral column is thus given a slightly lateral curvature, the root pockets from the deepest point, so that the contrast medium Metrizamide can run into them. Sometimes tomography is used. When treating a baby, the lateral cervical puncture was performed with the patient lying in a prone position, so that the root pockets could be demonstrated on both sides.

Diagnosis, Differential↗
PubMed1979

[Water intoxication and brain edema in psychogenic polydipsia (author's transl)].

A case of psychogenic polydipsia is presented that showed psychic decompensation and compulsive drinking under the acute stress of an imminent operation for ovarian cyst. Without any indication of an underlying organic disease process the patient developed acute water intoxication due to the uncontrolled intake of water from the tap, this caused hyponatremia, brain edema, coma and status epilepticus. The physiology of water intoxication is reviewed in relation to this case, which is also remarkable for the acute onset and the shortness of the polydipsic state.

Adult↗