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Biomedical subjects

H Favre

Publications and source records attributed to H Favre.

At least 109 records · Page 6Linked to original sources
PubMed1980

Osmolar influences on urinary acidification and metabolism in the Colombian toad bladder.

An increase in the osmolarity of the serosal fluid bathing the isolated toad bladder inhibits sodium transport across the preparation. Opposite effects occur with a decrease in serosal Ringer osmolarity. The present experiments investigate the specificity of these osmolar effects by examining the role of extracellular fluid tonicity on the acidification capacity of the isolated Colombian toad bladder. Acidification, estimated by the reversed short-circuit current (RSCC) developing across the Colombian toad bladder in the absence of sodium transport, was stimulated by serosal hypotonicity and inhibited by serosal hypertonicity of acetazolamide. Changes in the mucosal Ringer tonicity had no effect on RSCC. A direct correlation was found between the acidification process and the rate of oxidation of [14C]pyruvate by quarter-bladders exposed to changes in extracellular fluid osmolarity in the presence of amiloride. The osmolar effects on RSCC may result from changes in cell metabolism.

Acetazolamide↗
PubMed1980

Foot and mouth disease virus production on microcarrier-grown cells.

The industrial usefulness of the production of foot and mouth disease virus with microcarrier grown cells has been tested at a large scale. The vaccines, intended for pigs, prepared with such virus give a good level of immunity against virulent challenges. They are stable and free from side effects.

Animals↗
PubMed1979

[Hemoglobin D Punjab. Apropos of 2 families].

Two families who are carriers of hemoglobin DPunjab in the heterozygous state are described. This is the first time hemoglobin DPunjab has been reported in Switzerland. The propositus of the first family had two periods of acute hemolysis, probably drug-induced, which were followed by reversible renal complications and which led to the discovery of the hemoglobin. Study of the second family was undertaken because of anemia in one of its members.

Aged↗
PubMed1979

[Evaluation in hospital practice of Fecatest, a new laboratory method for the detection of occult blood in feces].

The clinical significance of the laboratory information provided by Fecatest, a new test based on a guaiac reaction for detecting occult blood in the feces, has been determined. In 93.8% of 243 patients with a lesion of the gastrointestinal tract diagnosed by endoscopy and/or radiology the test was positive; 88.5% of 148 patients in whom no lesion had been found by the same methods had a negative test. In vivo and in vitro comparison of the degree of sensitivity of Fecatest with Hematest and Haemoccult showed the following ratios: Hematest 5, Fecatest 3, Haemoccult 1. In point of sensitivity Fecatest thus comes between the other two tests investigated. It is concluded that Fecatest is a valuable tool in detecting lesions of the gastrointestinal tract associated with occult bleeding. The results show a better degree of clinical correlation between the test and the lesions in the gastrointestinal tract than with the other two. This view is further strengthened by the important practical advantages offered by Fecatest.

Evaluation Studies as Topic↗
PubMed1979

Role of the basal sodium intake in the rats on their response to a natriuretic factor.

A previously described natriuretic factor found in urine from man and dogs receiving a high salt diet has been postulated to be of hormonal nature. In order to test this hypothesis, natriuretic factor obtained from a pool of human urine of a standard activity has been injected into rats fed 0.55 (group A), 3.55 (group B), 6.55 (group C) mEq sodium a day as it has been shown that the endogenous activity of this factor depends on the sodium content of the diet. This material induces an increment of the UNaV and FENa in the rats averaging respectively 429.6 +/- 150.1% and 317.5 +/- 71.14% for the rats from group A, 103 +/- 29% and 99.7 +/- 26.25% for the rats from group B, 56.3 +/- 34.4% and 63.2 +/- 35.8% for the rats from group C reflecting the degree of statistical significance observed between the absolute values obtained during the control and experimental periods for each group. In addition, a dose-response curve has been established. Altogether the results suggest the hormonal nature of the natriuretic factor and design the kidney as the target organ. These data allow to define the best conditions under which the rats have to be in order to provide a valuable bioassay for this natriuretic material.

Animals↗
PubMed1979

Autoimmune hematologic diseases associated with infraclinical systemic lupus erythematosus in four patients. A human equivalent of the NZB mice.

In four patients with a diagnosis of autoimmune hemolytic anemia or idiopathic thrombocytopenic purpura antinuclear antibodies and circulating immune complexes (Clq-BA test) have developed at some time in their history. Renal biopsy material was assayed with different methods. Immunofluorescence studies revealed granular deposits of immunoglobulin G (IgG), immunoglobulin M (IgM) and third component of complement (C3). Upon optic microscopy, three patients had mild mesangial proliferation, one a focal glomerulonephritis. Upon electron microscopy, all patients exhibited mesangial and/or subendothelial deposits. The patients have been followed for 18 to 37 years since the beginning of their disease. There has been no clinical evidence of systemic lupus erythematosus (SLE), although they present in their glomeruli immunologic and anatomic features compatible with this disease. These patients seem to be a human equivalent of the black NZB mouse which presents immunohematologic disorders and some biologic markers of SLE without having a full clinical picture of SLE.

Adult↗
PubMed1978

[Metabolites of hypoglycemic sulfonylureas in kidney failure. Experience with glibenclamide].

Renal insufficiency is a factor which predisposes to hypoglycemic accidents in subjects treated with hypoglycemic sulfonylureas. Glibenclamide (glyburide) is eliminated from the body mainly by metabolism, with the result that renal insufficiency has little effect on its biotransformation. In order to determine to what extent the retention of the metabolities intervenes in such hypoglycemic accidents, rats with ligatured ureters received intraperitoneal injections of 1 mg/kg glibenclamide or hydroxy-glibenclamide (the main metabolite), or of saline. For each animal there was a control animal which had undergone a simulated operation. For six rats with renal insufficiency, glibenclamide caused hypoglycemia of the same intensity as in the control group but more prolonged. With hydroxy-glibenclamide the glycemia was signficantly lower than in the control group. Hydroxy-glibenclamide has an obvious hypoglycemic activity which represents 1/6 of that of the parent drug, but 50--100 times that of tolbutamide. Its retention contributed to the intensification and prolongation of the hypoglycemic effect of glibenclamide in rats with renal insufficiency.

Acute Kidney Injury↗
PubMed1978

Critical study of the value of renal clearances measured by the single shot technic.

A critical approach to the problem of establishing new methods of measurement of kidney function is presented. Variability of the reference clearances inulin and PAH is large, thus reference method ratios close to 1 are not sufficient to ascertain the value of the method under investigation. EDTA 51Cr and hippuran 125I, single shot technics illustrate the need for more accurate criteria required for validating a new technic.

Aminohippuric Acids↗
PubMed1978

[Prevention of animal rabies by an attenuated monovalent or mixed vaccine].

In view of the advantages and disadvantages of the different rabies vaccines, classified according to the production method of the virus and according to their nature - activated or inactivated - the choice of an activated vaccine produced on cell cultures is particularly justified for developing countries. The production of this type of vaccine, as well as the methods and results of the activity and innocuity controls are shown in detail. The interest of combined vaccines for certain developing countries, particularly the combined vaccine rabies/foot-and-mouth disease for ruminants, is stressed. The use of this type of vaccine on a vary large scale (more than 20 million doses up to this date) has given complete satisfaction. It should be noted that the same principles have been successfully applied to the realisation of a vaccine for human use, which can be administered before as well as after contamination.

Animals↗
PubMed1977

[Evaluation of the role of circulating antigen-antibody complexes in the pathogenesis of glomerular nephropathies].

Immunofluorescence studies of the glomeruli in patients suffering from glomerulonephritis (GN) suggest the deposit of immune complexes from the circulating blood. Immune complexes were quantitated using a sensitive radioimmunoassay from sera of 41 patients with GN drawn at the time when renal biopsy was performed. Simultaneously, degradation products of C3 (C3d) were measured. Eleven of 12 patients with GN secondary to a systemic disease (usually LED) presented increased C1q-binding activity of their sera (C1q-BA). C3 was further demonstrated in 9 of these patients, suggesting the presence of circulating immune complexes. By contrast only 2 of 12 patients with idiopathic GN characterized by deposits of complement and IgG in the glomeruli exhibited increased C1q-BA. One of 17 patients with idiopathic GN without deposit of immunoglobulins and C3 in the glomeruli also had increased C1q-BA. The results observed in the group of patients with idiopathic GN with glomerular deposits could be accounted for either by a transitory or minimal presence of immune complexes or by local formation of complexes in the glomerular structures.

Antigen-Antibody Complex↗
PubMed1977

[Side effects of nalidixic acid in a patient with severe renal failure. Clinical study and proposal of a pharmacokinetic model].

Side effects due to ingestion of nalidixic acid in a 46 year old patient with phenacetine-induced interstitial nephritis and severe renal failure are reported. This observation underlines the point that, besides the direct neurotoxic effect of nalidixic acid, disturbance of the acid-basic equilibrium could be seen in patients with renal failure in particular. A hypothetical pharmacokinetic model suggests that two metabolites of nalidixic acid could provide enough hydrogen ion to induce acidosis in cases of renal failure.

Acid-Base Imbalance↗