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Biomedical subjects

H Fabel

Publications and source records attributed to H Fabel.

At least 109 records · Page 6Linked to original sources
PubMed1985

[Clinical picture of bacterial pneumonias and their differential diagnosis].

Under the influence of antibiotic therapy, bacterial pneumonias have undergone a remarkable change in the last few decades. Individual forms of pneumonia can be distinguished morphologically by their localization, the way in which they spread, their limitations, and their course. Clinically, opportunistic bacterial infections predominate. Increasingly, secondary pneumonias are observed in poststenotic areas, areas of infarction, in hypostatic areas, after aspiration, and in previously damaged lobes. Radiologic criteria for differentiating from atypical pneumonias (viruses, mycoplasmas and chlamydia) are discussed.

Bacterial Infections↗
PubMed1980

[Lung function, gas exchange and regulation of ventilation in patients with portocaval encephalopathy (author's transl)].

In 17 patients, breathing room air and pure oxygen, with histologically proven cirrhosis of the liver and portocaval encephalopathy grade I, static and dynamic lung volumes, closing capacity and arterial blood gases were determined. Furthermore, CO2, response curves were provided and mouth occlusion pressure measurements were carried out. The residual volume was found to be increased (130 +/- 8% of predicted) which resulted in decreased vital capacity (79 +/- 2% of predicted) with total lung capacity being normal (94 +/- 2% of predicted). Closing capacity was increased to 134 +/- 5% of the predicted value. Gas exchange for oxygen was impaired (AaDO2 = 262 +/- 30% of predicted). Arterial PO2, however, was within normal range PaO2 = 84 +/- 3.6 mm Hg) due to hyperventilation (PaCO2 = 28.1 +/- 0.8 mm Hg). Hypoxic ventilatory stimulation could be excluded because inspiration of pure oxygen caused no change of PaCO2 (PaCO2 = 27.3 + 0.7 mm Hg and PaO2 = 465 + 16.9 mm Hg with FIO2 = 1.0). The slope of the CO2 response curves was normal, the mouth occlusion pressures, however, were higher than the predicted value: up to PaCO2 of 55 mm Hg. The slope of these curves being smaller than predicted. The results show that in patients with portocaval encephalopathy the lung function is disturbed due to premature airway closure with consequently decreased regional ventilation: perfusion ratios and that regulation of ventilation is impaired by a loss of sensitivity for CO2 with high basal output of the respiratory centers not related to CO2.

Blood Gas Analysis↗
PubMed1980

[Effect of potent analgesics on the ventilatory CO2 response and on the mouth occlusion pressure (author's transl)].

The depressant effects of four potent analgesics on the respiration were studied in 9 healthy young persons by determining the CO2 response (Read's method) and the mouth occlusion pressure (Whitelaw's method) before and after administration of the drugs and with or without interposition of additional inspiratory resistance (Rin). The analgesics tested were: Mr. 1268 = M1; pentazocine = M2; tramadol = M3; Mr. 1353 = M4. M1 and M2 induced a marked reduction in the ventilatory CO2 response (56.2 per cent +/- 21.8 for M1 and 53.8 per cent +/- 17.1 for M2). Interposition of Rin reduced the response to 43.9 per cent +/- 15.5 and 41.7 per cent +/- 17.3 respectively of the normal value. The occlusion pressure fell to 54.3 +/- 17 and 49.4 per cent +!- 22.2 respectively. After interposition of Rin the values were reduced 89 per cent +/- 27.3 and 79.9 +/- 29 respectively from the original value of 152.2 +!- 34.6. Administration of M3 or M4 did not significantly affect either the CO2 response or the occlusion pressure, nor had interposition of Rin any effect. M1 and M2 also induced changes in the ratio central stimulus P100/resultant flow (VT/Ti), viz.: M1 +/- SD: 77.1 per cent +/- 7.1; M2 +/- SD: 77.3 +/- 14.1. M3 and M4 had no significant effect M3 = 92.3 per cent +/- 9.1; M4 = 93.9 per cent +/- 13.3). The data indicate that the two methods make it possible to quantify that the two methods make it possible to quantify the respiratory depression induced by drugs and to differentiate between central respiratory depression and additional impairment of respiratory mechanics.

Adult↗
PubMed1975

[Dose-effect study on the bronchospasmolytic drug ipratropium bromide in relation to blood gases and hemodynamics].

In 9 patients with chronic bronchitis and cor puomonale and in one patient with vascularly pulmonary hypertension the efficiency of 0,04 mug and 0,16 mug Sch 1000 (isopropylatropin,), applicated with metered dose inhaler referring to blood gases and hemodynamics was examined. Inhalation of drug was not followed by any variations either referring to hemodynamic parameters (pulmonary pressure, systemic blood pressure, cardiac output, peripheral resistance) nor to the blood gases. After a dosage as high as eigth time as normal side effects were not found.

Arrhythmias, Cardiac↗