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Biomedical subjects

H FRIEDMAN

Publications and source records attributed to H FRIEDMAN.

At least 19 recordsLinked to original sources
PubMed1965

INDUCTION OF NONSPECIFIC RESISTANCE BY ENDOTOXIN IN UNRESPONSIVE MICE.

Margherita, S. S. (Temple University School of Medicine, Philadelphia, Pa.), and H. Friedmann. Induction of nonspecific resistance by endotoxin in unresponsive mice. J. Bacteriol. 89:277-280. 1965.-Serratia marcescens endotoxin was tested for protective effect in animals of varying immunological competence. A quantity of endotoxin capable of inducing resistance in mice to a standardized challenge of Diplococcus pneumoniae was equally effective in animals immunologically paralyzed with a high dose of homologous pneumococcal polysaccharide. Failure of the unresponsive state to influence the degree of resistance induced by endotoxin suggests that a specific humoral factor does not play a significant role in the nonspecific resistance.

Allergy and Immunology↗
PubMed1964

ANTIBODY PLAQUE FORMATION BY NORMAL MOUSE SPLEEN CELL CULTURES EXPOSED IN VITRO TO RNA FROM IMMUNE MICE.

Suspensions of normal spleen cells from nonimmune mice were treated in vitro with RNA extracted from spleen cells from donor mice immunized 4 days previously with sheep erythrocytes. Subsequent incubation of the RNA-treated cells in tissue culture medium at 37 degrees C for several days resulted in a marked increase in the number of localized zones of hemolysis ("antibody plaques") in relation to the number of viable cells plated in agar containing sheep erythrocytes and complement. Nonimmune cells maintained in tisse, culture medium did not form plaques after incubation with either RNA from Immune mice or ribonuclease-treated RNA from immune mice, or with RNA from non-immune donor mice, or from donors immunized with chicken erythrocytes or bovine serum albumin.

Animals↗
PubMed1964

INHIBITION OF ANTIBODY PLAQUE FORMATION BY SENSITIZED LYMPHOID CELLS: RAPID INDICATOR OF TRANSPLANTATION IMMUNITY.

Spleen cell suspensions obtained from mice immunized with sheep erythrocytes form localized zones of hemolysis ("antibody plaques") when incubated in agar gel containing sheep red blood cells and complement. Plaque formation can be inhibited by prior incubation in vitro with spleen cell suspensions from another strain of mice previously sensitized to the first by spleen cell transplant. Suppression of plaque formation was found to be quantitatively related to the number of cells incubated and apparently reflected a homograft reaction in vitro of one spleen cell population against another. Plaque inhibition may be a useful indicator of transplantation immunity.

Animals↗
PubMed1964

MEASLES AND MEASLES VACCINATION IN AN AFRICAN VILLAGE.

Over the last five years, a number of reports have appeared drawing attention to the serious results of measles in young West African children. This is borne out by observations over a three-year period on children in the village of Imesi, which showed measles to be a severe and often fatal disease. The original live attenuated measles vaccine developed by Enders has been shown to give good protection and, in combination with immune serum, has been widely used in the USA. However, the need to combine it with immune serum severely limits its usefulness, owing to the small quantities of serum available and the high cost. In the present study, the reaction produced by the original vaccine with immune serum was compared with the reaction produced by a further attenuated vaccine without serum. The latter gave significantly fewer and less severe reactions, but produced a satisfactory serological response. This new vaccine should facilitate large-scale immunization of children in areas such as West Africa where protection against measles is urgently required.

Africa↗