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Biomedical subjects

H F Young

Publications and source records attributed to H F Young.

At least 109 records · Page 6Linked to original sources
PubMed1980

Chronic neck and back pain: a reassessment of usual surgical treatment.

One hundred seventeen patients with chronic (noncancerous) back or neck pain had multidisciplinary evaluation in the Medical College of Virginia Pain Center and were followed up for one year. They ranged in age from 26 to 57 years. The 57 patients who had surgery had an average of 2.5 procedures (either laminectomies or back fusion) and only five of them returned to work. By contrast, 16 of 60 patients who had not had operation were able to secure employment after evaluation and treatment in the Pain Center.

Back Pain↗
PubMed1980

The use of the laser in neurological surgery.

Lasers generate unidirectional beams of monochromatic, and temporally and spatially coherent electromagnetic radiation that are capable of vaporizing and coagulating biological tissue. Specific physical characteristics of laser energies of different wavelengths impart to each form of surgical laser specific potentials for clinical use in neurological surgery. The major advantages of surgical lasers appear to be improved precision, reduction of surgically related mechanical trauma, reduction of blood loss, and decreased operative time. Improvement of operative mortality and morbidity and increased longevity that might result from its use would make the laser cost effective.

Argon↗
PubMed1980

Radiological evaluation of cerebello-pontine angle epidermoid tumor.

The authors present a case of cerebello-pontine angle epidermoid tumor with emphasis on radiologic investigation. The limitation of computerized tomography in the proper evaluation of these lesions and the complementary role of studies like pneumoencephalography is discussed.

Adult↗
PubMed1978

Blue-domed cyst with optic nerve compression.

A patient presenting with persistent headache of vascular quality and an intermittently progressive chiasmal syndrome had a blue-domed haemorrhagic cyst beneath the right optic nerve and underwent surgical drainage with good results. As prompt surgical intervention may proivde significant return of visual function, detailed diagnostic evaluation of similar cases is recommended.

Adult↗
PubMed1978

Microsurgical cerebral revascularization for the treatment of stroke.

A study of 1,000 STA-MCA by-pass procedures in stroke patients is described as "extremely encouraging", with greater than 90% patency rate and marked improvement in patients who had not responded to medical management or had been turned away from routine vascular surgery.

Cerebral Arteries↗
PubMed1978

Myelopathy presenting as an intrinsic spinal cord tumor.

Two patients are presented who became progressively quadriplegic with myelographic appearances suggesting intrinsic spinal cord tumors. In both cases, laminectomy and biopsy of the spinal cord disclosed non-neoplastic conditions (neuromyelitis optica and acute necrotic myelopathy) confirmed at autopsy. Since surgery is not helpful in such cases, the problems of differentiation between such lesions and intraspinal tumors are reviewed.

Adolescent↗
PubMed1977

Immune complex disease associated with an infected ventriculojugular shunt: a curable form of glomerulonephritis.

A 22-year-old man with a ventriculojugular shunt had edema, hematuria, proteinuria, hypocomplementemia, azotemia, and S epidermidis bacteremia. Initial percutaneous renal biopsy showed a diffuse proliferative glomerulonephritis. Subendothelial and intramembranous deposits were seen on electron microscopy. Immunofluorescent studies were positive for IgG and C3. A repeat percutaneous renal biopsy six weeks after cessation of antibiotic therapy revealed a mild proliferative glomerulonephritis with some evidence of resolution. No deposits were seen on electron microscopy and immunofluorescent studies were negative. At elective shunt revision three months after cessation of therapy, culture of the jugular portion of the removed shunt revealed S epidermidis. Early recognition of immune complex glomerulonephritis occurring with an infected ventriculovascular shunt should permit early treatment (antibiotic therapy and removal of the infected foreign body) and a favorable outcome.

Adult↗
PubMed1977

The outcome from severe head injury with early diagnosis and intensive management.

In the belief that secondary cerebral compression, hypoxia, and ischemia materially influence the outcome from severe head injury, a standardized protocol was followed in 160 patients, with emphasis on early diagnosis and evacuation of intracranial mass lesions by craniotomy, artificial ventilation, control of increased intracranial pressure, and aggressive medical therapy. Of these patients, 36% made a good recovery, 24% were moderately disabled, 8% were severely disabled, 2% were vegetative, and 30% died. The mortality rate compares favorably with outcomes in similar patients reported from other centers and there has been no increase in the numbers of severely disabled or vegetative patients. It is proposed that vigorous surgical and medical therapy, by preventing or reversing secondary cerebral insults, enables some patients who would have died to make a good recovery without increasing the proportion of severely disabled patients.

Adolescent↗
PubMed1977

Pancreatitis following spinal cord injury.

Six cases of pancreatitis following spinal cord injury are presented. No single, etiologically accepted mechanism already postulated to cause pancreatitis can account for all the cases reported. The authors hypothesize that spinal cord disruption may produce pacreatitis by sympathetic-parasympathetic nervous system imbalance resulting in over-stimulation of the sphincter of Oddi. This may lead to stasis of secretions with absorption of amylase into the systemic circulation, and structural pancreatic damage. Pancreatitis in those with cord injuries is easily overlooked because abdominal pain is usually absent and fever is usually attributed to more frequently occurring pulmonary or urinary tract infections. Recognition of this complication is important in order to decrease the morbidity and mortality that follows spinal cord damage.

Adult↗
PubMed1976

Organ culture of craniopharyngioma and its cellular effects induced by colloidal chromic phosphate.

Since a marked clinical improvement has been reported following chromic phosphate treatment in recurrent craniopharyngioma, we have attempted to study the in vitro cellular changes of two craniopharyngiomas maintained in organ culture system and subsequently treated with colloidal chronic phosphate. When incubated for 24 and 48 hours respectively, at a concentration of 10 muCi/ml. of colloidal 32P, only vacuolar degeneration and hyperchromasia of the tumor cells have been observed. When incubated with 50 muCi/ml. for 24 hours, further cellular degeneration and focal necrosis begin to appear. Up to 48 hours after 50 muCi/ml. obvious necrosis and extensive degeneration become apparent. Autoradiography confirms the fact that radioactive material is absorbed by the tumor cells. Brain tumors when maintained in an organ culture system may serve as a useful model for the evaluation of the effects of various chemotherapeutic and radiotherapeutic agents in vitro.

Adult↗
PubMed1976

Inhibition of cell-mediated immunity in patients with brain tumors.

The immunocompetence of patients with glioblastomas, but not patients with astrocytomas, is altered. In vitro testing demonstrates an inhibitory factor in the serum of patients with glioblastomas which impairs lymphocytic responsiveness. The degree of this impairment appears important in relation to the clinical course.

Adult↗
PubMed1975

Unusual, rod-shaped cytoplasmic inclusions (Hirano bodies) in a cerebellar hemangioblastoma.

The present study reports unusual, long, tubular, rod-shaped cytoplasmic inclusions found in the stromal cells of a cerebellar hemangioblastoma, associated with von Hippel-Lindau syndrome. These inclusions have two layers of circular, laminated filaments, and longitudinally arranged filaments; and appear similar to the so-called "Hirano bodies", which have been previously found in normal and various pathologic conditions of the brain tissue, skeletal muscle cells in myopathy, and interstitial cells of the testis. A review of previous ultrastructural studies of cerebellar hemangioblastoma shows several different types of cytoplasmic inclusions, but none are found to be identical to the present report.

Adenocarcinoma↗