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Biomedical subjects

H F Sears

Publications and source records attributed to H F Sears.

64 records · Page 4Linked to original sources
PubMed1976

Granulocytic sarcoma: local presentation of a systemic disease.

The case of a pregnant woman with a breast mass that proved to be a granulocytic sarcoma is presented. Her systemic therapy was initiated at a time when her tumor burden was possibly relatively low and a good response to the aggressive combination chemotherapy including Daunomycin was obtained. She was successfully carried through pregnancy and delivered a normal child despite combination chemotherapy. Factors relating to her case have been reviewed in the literature.

Adult↗
PubMed1976

Citrate anticoagulation and cell washing for intraoperative autotransfusion in the baboon.

Extracorporeal citrate was used for anticoagulation during autotransfusion of baboons. A cell-washing plasmaphoresis procedure was added in one group of animals in order to remove activated clotting materials. Both groups became hypocoagulable, but the cell-washed group had less evidence of disseminated intravascular coagulation as well as lower plasma hemoglobin levels. Citrate anticoagulation plus cell washing is a potential alternative to heparinization for autotransfusion.

Animals↗
PubMed1975

Liver scan and carcinoma of the breast.

The results of 100 liver scans obtained as part of the preoperative evaluation of patients known to be harboring a potentially resectable carcinoma of the breast were evaluated. Of the five positive results of these studies, four were found to be falsely positive. During the period included in the study, 317 other liver scans were performed on patients known to have recurrent, residual, or metastatic disease or on patients returning for routine postoperative evaluation. The information derived from these studies was of practical significance only in the group receiving therapy for the secondary tumor. On the basis of this small series, the routine use of the liver scan in evaluating the patient with carcinoma of the breast cannot be supported.

Breast Neoplasms↗
PubMedDate not supplied

Longitudinal studies of cellular immunity of patients with osteogenic sarcoma during chemoimmunotherapy.

The cellular immune reactivity of 24 patients with osteogenic sarcoma was studied longitudinally during surgical treatment and subsequent adjuvant chemoimmunotherapy. Cellular immune function was studied using in vitro assays of lymphocyte reactivity to mitogens and nonspecific allogenic antigens. Circulating cells were characterized by the total lymphocyte and wbc counts, determination of E-rosetting populations, and percent of polymorphonuclear leukocytes. Both fresh and cryopreserved lymphocytes were utilized and compared. The preoperative values from these studies offered no useful indication of those patients likely to have disease recurrence. Likewise, longitudinal studies during the course of adjuvant treatment did not predict relapse before other routine clinical studies could identify it. There was no difference in the studied lymphocyte functions and hematologic tests between the group receiving BCG immunotherapy and those not receiving BCG. Our studies indicate that current measures of cellular immune function are of little value in the monitoring of patients with osteogenic sarcoma.

Antineoplastic Agents↗