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Biomedical subjects

H F Frierson

Publications and source records attributed to H F Frierson.

160 records · Page 9Linked to original sources
PubMed1985

Olfactory neuroblastoma. A clinicopathologic study of 21 cases.

The clinicopathologic features of 21 olfactory neuroblastomas are reviewed with emphasis on variables of potential diagnostic or prognostic value. The patients ranged in age from 9 to 66 years (median: 49 years); 57% were women. At the time of diagnosis, one tumor was Kadish stage A, 11 were stage B, and nine were stage C. Nineteen patients had extensive surgical resections, but in six instances these were considered incomplete. Six patients (29%) developed local recurrences and eight (38%) had metastases. Ten patients (48%) were alive and free of disease from 10 to 239 months (median: 58 months) after diagnosis. Seven (33%) died of tumor, with a duration of survival ranging from 1 to 142 months (median: 27 months). A fibrillary intercytoplasmic back-ground was the most useful diagnostic feature microscopically and was present, at least focally, in 18 of 21 tumors. A silver stain for neuronal processes was helpful when fibrils could not be seen on hematoxylin- and eosin-stained sections. Homer-Wright rosettes, when present, also aided in diagnosis but were well formed in only six tumors. The only clinical feature that correlated with prognosis was whether the neoplasm had been completely excised at initial presentation. Tumor necrosis was the only histologic feature correlating with prognosis, but neither association was statistically significant. Metastases, clinical stage, mitotic rate, and nuclear pleomorphism showed no relationship to survival in this series.

Adolescent↗
PubMed1984

Non-Hodgkin's lymphomas of the sinonasal region: histologic subtypes and their clinicopathologic features.

The authors describe 11 patients with non-Hodgkin's lymphoma arising in the nasal cavity or paranasal sinuses. Seven were men and four were women. The median age of the women was 76 years; the median age of the men was 45 years. The most common presenting symptoms were nasal obstruction and unilateral facial swelling. The most frequent sites of disease were maxillary antrum (ten cases), nasal cavity (eight cases), and ethmoid sinus (seven cases). Eight patients had involvement of multiple sinuses. Six patients were clinical stage I E, two were II E, one was stage III E, and two were stage IV. Histologic subtypes included diffuse small cleaved cell (1 case), diffuse large cell (4 cases), and diffuse large cell immunoblastic (6 cases). Three patients having immunoblastic lymphoma had longstanding sinusitis, rhinitis, and allergies. Overall, 55% of patients died of disease. Three of four patients with the diffuse large cell subtype were free of tumor (mean follow-up 50 months). Five of six patients having immunoblastic lymphoma died of disease from 1 to 13 months following diagnosis (mean 6.4 months).

Adolescent↗
PubMed1984

Association of juvenile xanthogranuloma with juvenile myeloid leukemia.

Multiple cutaneous xanthomas developed in a patient at the age of 10 months, and juvenile chronic myeloid leukemia (JCML) developed at the age of 30 months. The xanthomas were histopathologically consistent with a diagnosis of juvenile xanthogranuloma (JXG). A review of other cases of JCML with JXG indicates that the cutaneous lesions have many clinical and histopathologic similarities to sporadic JXG but are more often multiple or papular and confluent. In addition to JXG, a few children with JCML also have multiple café-au-lait spots and a family history of neurofibromatosis.

Female↗
PubMed1984

Papillary eccrine adenoma.

An example of papillary eccrine adenoma was seen. This benign cutaneous tumor has a diagnostic microscopic appearance that consists of multiple ducts lined by two or more layers of cells. The inner layer often forms one or multiple papillae of variable complexity. The stroma consists of patches of loosely arranged spindled cells and areas of hyalinized collagen. The latter often forms bands about the ducts. In addition to the foregoing, we observed focal squamous differentiation, clear cell change, connection of ducts to the epidermis, and prominent nerves within the stroma. Papillary eccrine adenoma also has several characteristic clinical features. The tumors are firm or hard nodules, frequently of many years' duration, and a large proportion are situated on the extremities of black persons.

Cystadenoma↗
PubMed1983

Myxoid variant of dermatofibrosarcoma protuberans.

We describe two cases of dermatofibrosarcoma protuberans that were entirely myxoid when excised initially. The tumors had the following distinctive histologic features: 1) a monotonously haphazard arrangement of spindle-shaped and stellate tumor cells; 2) little variation in cellularity from field to field; 3) pale basophilic to clear stroma containing hyaluronic acid; 4) minimal cytologic pleomorphism and a low mitotic rate; 5) a dispersed, nonpatterned vasculature; 6) eccrine structures and fat cells trapped and surrounded by tumor tissue; and 7) areas where spindled cells had a parallel arrangement evocative of neurofibroma. A cutaneous tumor with the foregoing features should be carefully examined for subtle, radial arrangements of tumor cells and a tentacular or course, web-like infiltration of any attached fat. Use of the foregoing criteria will allow distinction between myxoid dermatofibrosarcoma protuberans and other myxoid tumors of the skin.

Adipose Tissue↗
PubMed1983

Subcutaneous neutrophilic infiltrates in acute febrile neutrophilic dermatosis.

A patient had an evolving hematologic disorder, accompanied by tender, red, subcutaneous nodules. Histologically, there were dense neutrophilic infiltrates confined to the subcutaneous adipose tissue. Three months later, a typical episode of acute febrile neutrophilic dermatosis (ND) developed in the patient, and she was found to have acute myeloid leukemia. In addition to the dermis, the neutrophilic infiltrates of ND occasionally involve the subcutis. As seen in our patient, the infiltrates are rarely limited to the subcutaneous tissue.

Acute Disease↗
PubMedDate not supplied

Radiotherapy for basaloid squamous cell carcinoma of the head and neck.

Basaloid squamous cell carcinoma (BSCC) of the head and neck is a recently described high-grade variant of squamous cell carcinoma. It is a biologically virulent neoplasm with a propensity for nodal, as well as systemic, metastases. Because of the limited number of published reports, we reviewed data from patients of the University of Virginia Health Sciences Center and identified 16 cases of BSCC. The intent of this study was to determine the role of radiotherapy in the treatment of BSCC and better define the clinical features of this entity. Radiotherapy alone, or in combination with surgery, resulted in excellent local control rates. Distant metastases, chiefly pulmonary, occurred in more than half of the patients.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Novel DNA copy number losses in chromosome 12q12--q13 in adenoid cystic carcinoma.

In order to find common genetic abnormalities that may identify loci of genes involved in the development of adenoid cystic carcinoma (ACC), we investigated DNA copy number changes in 24 of these tumors by comparative genomic hybridization (CGH). Our results indicate that unlike many carcinomas, ACCs have relatively few changes in DNA copy number overall. Twenty tumors had DNA copy number changes, which were mostly restricted to a few chromosomal arms. A frequent novel finding was the loss of DNA copy number in chromosome 12q (eight tumors, 33%) with the minimal common overlapping region at 12q12--q13. Deletion in this region has not been reported to be frequent in other types of cancer analyzed by CGH. In addition, deletions in 6q23-qter and 13q21--q22 and gains of chromosome 19 were observed in 25% to 38% of ACCs. Deletion of 19q, previously reported in a small series of ACC, was not identified in the current group of carcinomas. The current CGH results for chromosomes 12 and 19 were confirmed by microsatellite allelotyping. These results indicate that DNA copy number losses in 12q may be important in the oncogenesis of ACC and suggest that the 12q12--q13 region may harbor a new tumor-suppressor gene.

Adult↗
PubMedDate not supplied

Infiltrating angiolipoma of skeletal muscle: MR findings.

Infiltrating angiolipoma of skeletal muscle is a rare benign tumor that has a tendency to recur unless completely excised. Although CT and angiography have been used to determine its extent, they will not allow a definite diagnosis. We present magnetic resonance findings and assert that an accurate preoperative diagnosis can be made based on those findings.

Child↗
PubMedDate not supplied

Fine needle aspiration cytology of acinar cell carcinoma of the pancreas: a report of two cases.

BACKGROUND: Fine needle aspiration in lieu of needle biopsy is widely used for the diagnosis of pancreatic neoplasms. The cytologic features of ductal carcinomas are well characterized, but the appearances of less common pancreatic neoplasms, such as acinar cell carcinoma (ACC), are not well described. CASES: We present the cytologic, histologic, immunocytochemical and ultrastructural features of two cases of ACC. The tumors occurred in a 36-year-old woman and 43-year-old man. The aspirate from one case contained neoplastic cells with smooth-contoured nuclei containing one or two prominent nucleoli. The aspirated material from the second case was necrotic, with numerous neutrophils and scattered nests of tumor cells similar to those present in the first case. Histologically, both tumors manifested solid and acinar patterns, and each contained some cells with periodic acid-Schiff-positive granules that were resistant to diastase. The neoplasms were immunochemically positive for trypsin and negative for neuroendocrine markers. Ultrastructurally, the aspirate from one case demonstrated apical microvilli, zymogenlike granules and abundant rough endoplasmic reticulum. CONCLUSION: Uncommon pancreatic neoplasms may be difficult to diagnose due to their cytologic and histologic subtleties. Supplemental studies including immunocytochemistry, cytochemistry and electron microscopy are important in facilitating their identification.

Adult↗
PubMedDate not supplied

Fine needle aspiration cytologic findings in metastatic basaloid squamous cell carcinoma of the head and neck.

Basaloid squamous cell carcinoma of the head and neck is a variant of squamous carcinoma the cytomorphology of which has not been examined previously. The cytologic features of metastatic basaloid squamous cell carcinoma in fine needle aspiration specimens from nine patients are described. The primary tumors, when known, were located in the base of the tongue, tonsil, epiglottis, nasopharynx, hypopharynx and false vocal cord. Each neoplasm had large fragments or clusters of crowded cells and scattered single cells in the cytologic smears. The cells had round or oval, hyperchromatic nuclei that often had single, small nucleoli. The nuclei usually were small or medium sized, but six tumors had a few cells the nuclei of which were large and pleomorphic. The cytoplasm was typically scant, and only three cases had occasional keratinized cells. Necrosis was present in six neoplasms. Three neoplasms, originally diagnosed as small cell undifferentiated carcinoma, contained numerous single cells and small clusters of cells with nuclear molding. On review, however, smears from these neoplasms also contained a few large fragments of tightly cohesive cells with larger, vesicular nuclei. Another basaloid squamous cell carcinoma had been interpreted elsewhere as an adenoid cystic carcinoma because of the presence of pseudoglandular structures with stromal cores. Although the cytologic features of basaloid squamous cell carcinoma may mimic those of other poorly differentiated carcinomas in fine needle aspiration specimens, they are sufficiently distinctive that a diagnosis of this variant of squamous cell carcinoma can be suggested for a patient whose primary neoplasm is located in the upper aerodigestive tract.

Adult↗
PubMedDate not supplied

Fine needle aspiration cytology of atypical carcinoid of the lung.

The cytologic features of eight atypical carcinoid tumors of the lung, as observed in fine needle aspiration (FNA) specimens, are described in detail. They were compared with 21 pulmonary squamous-cell carcinomas, 16 adenocarcinomas, 5 small-cell undifferentiated carcinomas, 3 large-cell undifferentiated carcinomas and 1 typical carcinoid tumor. Atypical carcinoid tumor was easily distinguished from the other pulmonary neoplasms in most instances. Only two poorly differentiated squamous-cell carcinomas (one of which had atypical carcinoid as a component) and one small-cell undifferentiated carcinoma had similar cytologic features. One atypical carcinoid also had cytologic features similar to small-cell undifferentiated carcinoma. Because atypical carcinoid and small-cell undifferentiated carcinoma, at times, may be difficult to separate in FNA specimens, surgical resection of all stage I neoplasms with cytologic features evocative of either neoplasm is recommended.

Adenocarcinoma↗
PubMedDate not supplied

The role of fine needle aspiration cytology in the diagnosis of lymphoma.

The accuracy of fine needle aspiration (FNA) cytology for the diagnosis of lymphoma and other hematolymphoid malignancies was investigated by a review of 158 FNA specimens from 143 patients. Patients included in the study had either a diagnosis of a hematolymphoid malignancy by FNA cytology or a biopsy diagnosis of lymphoma that was preceded by FNA cytology. Biopsy specimens were obtained from 85% of the patients. Of the 158 needle aspirates, 118 (75%) were diagnosed as lymphoma, 13 (8%) as suspicious of lymphoma, 8 (5%) as myelomas, 3 (2%) as leukemias, 12 (8%) as positive for malignancy and 4 (2%) as negative for malignancy. Two of the 118 needle aspirates diagnosed as lymphoma were false positives while 3 of 13 diagnosed as suspicious for lymphoma were found to be benign. Overall, there were four false negatives. Morphologic subclassification of the lymphomas, originally attempted for 60 needle aspirates, was identical to the histologic subclassification in 51 cases (85%). FNA cytology provided the initial diagnosis of a hematolymphoid malignancy in 51% of the cases and allowed the documentation of recurrent disease in 49%. The results demonstrate the usefulness of FNA cytology for the diagnosis and management of patients with lymphoma.

Biopsy, Needle↗
PubMedDate not supplied

Oncocytoid adenocarcinoma of the parotid gland. Cytologic, histologic and ultrastructural findings.

An oncocytoid adenocarcinoma of the parotid gland, diagnosed by fine needle aspiration cytology, is reported. The neoplasm, seen in a 66-year-old man, metastasized to 33 of 46 resected cervical lymph nodes; the patient is currently free of disease 17 months after surgery. Cytologically, the neoplastic cells occurred singly and in small clusters. They had abundant granular cytoplasm with occasional vacuoles, large nuclei and prominent nucleoli. Ultrastructurally, the tumor cells had copious cytoplasm, with moderately increased numbers of mitochondria, dilated endoplasmic reticulum, mucin droplets and intracytoplasmic lumina. The clinical importance of distinguishing this neoplasm from true malignant oncocytoma is, at present, unknown.

Adenocarcinoma↗