Surgeons must decide on the type of anesthesia to use when performing cataract surgery. These "viewpoints" articles provide a well-balanced discussion offering the pros and cons of both topical anesthesia and retrobulbar/peribulbar injection. Dr. Dutton gives an overview of both techniques, focusing on relevant orbital anatomy. Drs. Hassan, Edelhauser and Kim, review the various types of topical anesthesia currently in use, and Drs. Spriggs and Broocker examine retrobulbar and peribulbar injections. Both techniques are associated with advantages and risks, so each surgeon must decide which technique is best suited for his or her own practice.

Anesthesia, Local↗

PubMedDate not supplied

Corneal epithelial permeability after excimer laser photorefractive keratectomy.

PURPOSE: To evaluate the effect of excimer laser photorefractive keratectomoy (PRK) on the corneal epithelial barrier function. METHOD: Corneal uptake of 5,6 carboxyfluorescein (CF) was measured by Bernal and Ubels' method after excimer laser PRK in New Zealand white rabbits (N = 40). One cornea in each rabbit was treated, and the fellow cornea was used as a control. In both eyes, the central 7.0 mm of the corneal epithelium was removed. Myopic PRK treatments were performed at 37.75 microns (3.3 diopters [D]) and at 52.50 microns (5.0 D). The animals were euthanized and the eyes placed in CF for 5 minutes at 3 days, and at 1, 2, and 4 weeks following PRK. The corneas were then excised and dialyzed in balanced salt solution. The CF concentration in the dialysate was measured by fluorometry. Four corneas were also prepared for transmission electron microscopy using fixative containing ruthenium red. RESULTS: Three days after PRK, CF uptake increased in all study eyes compared with normal eyes (n = 5). One week after PRK, the control corneas showed a decreased CF uptake while the study corneas still had an increased CF uptake (P < .05). Two weeks after PRK, CF uptake in corneas with a 5.0 D ablation remained increased but decreased in corneas with a 3.3 D ablation (P < .05). Four weeks after PRK, CF uptake returned to normal in all corneas. The ruthenium red penetrated into the deeper layers of the corneal epithelium 1 week after PRK; only the superficial cell layer was stained 4 weeks after PRK. CONCLUSIONS: Excimer laser PRK affected the corneal epithelial barrier function at 1 and 2 weeks postoperatively even though the corneal epithelium covered the ablated area. Deeper laser ablations showed higher corneal CF uptake for longer periods than shallower ablations.

Animals↗

PubMedDate not supplied

Healing of corneal epithelial wounds in marine and freshwater fish.

The corneal epithelium of a fish is in direct contact with the aquatic environment and is a barrier to movement of ions and water into and through the cornea. This tissue layer is thus important in maintenance of corneal transparency. When the epithelium is wounded, its protective function is lost and corneal transparency remains compromised until the epithelial barrier is re-established. This study was undertaken to investigate the healing response of the fish cornea to epithelial abrasion. Wounds were stained with fluorescein and photographed during healing. Wound areas were measured by planimetry. The cornea of the sculpin, a marine teleost, becomes edematous after wounding and heals at 2.54 to 3.42 mm2/hr. Nonswelling corneas of the elasmobranchs--dogfish shark and skate--heal at 1.29 mm2/hr, respectively. The wounded eye of the rainbow trout, a freshwater teleost, is stressed by the low osmolality of the environment. Severe corneal edema and cataracts develop following epithelial wounding, and the cornea heals at 0.64 mm2/hr. Although the healing rates in teleosts differ from those in mammals, histology shows that the corneal healing mechanism is essentially the same in fish and mammals.

Animals↗

PubMedDate not supplied

Water permeability of normal and pathological lake trout corneas.

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Animals↗