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Biomedical subjects

H F Chen

Publications and source records attributed to H F Chen.

At least 109 records · Page 6Linked to original sources
PubMed1991

Intestinal permeability and bacterial translocation following small bowel transplantation in the rat.

In addition to its role in absorbing nutrients, the intestinal mucosa provides an important barrier against toxins and bacteria in the bowel lumen. The present study evaluated gut barrier function following orthotopic (in continuity) intestinal grafting in rats. Graft histology, intestinal permeability, and bacterial translocation to the grafted mesenteric lymph nodes, the host's liver, and the host's spleen were assessed on the 3rd, 5th, and 7th postoperative days. The study group received no immunosuppression after allotransplantation. The two control groups included rats with isografts and rats with cyclosporine-treated allografts. On the 7th POD, the study animals had moderate transmural inflammation due to rejection, with normal histology in the isografts and CsA-treated allografts; increased intestinal permeability, measured by urinary excretion of oral 51Cr-EDTA (P less than 0.01); and increased number of bacteria in the MLN and spleen (P less than 0.05). The number of bacteria in the MLN and spleen of the study group positively correlated with the changes in intestinal permeability (P less than 0.05). Rejection of the orthotopic intestinal graft leads to increased intestinal permeability and bacterial translocation from the lumen of the graft to the host's reticuloendothelial system. Measures to improve gut barrier function and antibiotic therapy during rejection episodes may help reduce the incidence of septic complications after intestinal grafting.

Animals↗
PubMed1989

Adjuvant chemotherapy after radical hysterectomy for cervical carcinoma.

Three hundred and sixty-eight cases of invasive cervical cancer (stage IB through early stage IIB) were treated with radical abdominal hysterectomy and bilateral pelvic lymphadenectomy at Chang Gung Memorial Hospital. Of these patients, 172 were classified postoperatively as a high-risk group after surgical-pathological assessment of tumor extent. Among these high-risk patients, 40 received adjuvant chemotherapy with cisplatin, vinblastine, and bleomycin (PVB), 38 received adjuvant radiotherapy, and 79 refused adjuvant treatment. The 3-year cumulative disease-free survival rate was 91.6% for the low-risk group and 59.7% for those at high risk. Among patients in the high-risk group, the 3-year survival rate was 75.0% for patients treated with adjuvant chemotherapy and 46.8% for those not treated with adjuvant therapy (P less than 0.05). The preliminary results of this pilot study showed a significant activity of adjuvant chemotherapy, which warrants further investigation of its role in the treatment of cervical cancer.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1986

Double-lined nomogram of cervical dilatation in Chinese primigravidas.

By studying normal labors in 500 Chinese primigravidae, a nomogram has been constructed to show the normal progression of cervical dilatation starting from cervical os of 3 cm dilatation. Paralleled 'alert' lines and 'action' lines were derived from this nomogram. Clinical evaluation of this double-lined nomogram showed that poor progression of cervical dilatation resulting in an abnormal outcome can be predicted at earlier stages. The use of this nomogram together with the partogram greatly improved the management of labor in the individual patient and the guidance of the labor ward as a whole.

Adolescent↗
PubMed1982

Computed tomography in the evaluation and treatment of endometrial carcinoma.

Since patients with endometrial carcinoma tend to be elderly, diabetic and hypertensive, individualization of treatment is very important. The therapy for each patient with endometrial carcinoma should be individualized and determined by the stage and factors predisposing to extrauterine spread of the tumor. Such risk factors include the grade of the tumor and depth of myometrial invasion. Unfortunately, staging based on pelvic examination is inaccurate in endometrial carcinoma and the depth of myometrial invasion cannot be assessed preoperatively. In order to assess its uses in the staging and treatment planning of endometrial cancer, CT was performed in 28 previously untreated patients with endometrial cancer. Twenty patients subsequently underwent surgery and the CT findings were correlated with the surgical and pathologic findings. CT proved to be useful in determining the depth of myometrial invasion and whether cervical involvement is present or not. Such information provided by CT helps to plan treatment more adequately and accurately for the individual patients.

Adult↗
PubMed1980

Studies on the purification and characterization of human urinary plasminogen and plasmin.

A new method is described for the preparation of highly purified human plasminogen and plasmin with specific activity of 32 CTA units per mg of protein. With this method, the purification of the urinary plasminogen + plasmin antigenic materials from patients with chronic glomerulonephritis, disseminated intravascular coagulation syndrome and severe toxemia of pregnancy was performed, and the resulting highly purified proenzyme and enzyme were analyzed by immunoelectrophoresis, separative agar electrophoresis, gel filtration and SDS-gel electrophoresis. Our findings indicated that urinary plasmin reflects more closely the extent of intraglomerular fibrinolysis, while urinary plasminogen reflects non-selective proteinuria in patients with chronic glomerulonephritis or severe toxemia of pregnancy.

Animals↗
PubMed1980

Urinary fibrinolysis in toxemia of pregnancy.

Serial determinations of urinary plasmin level by radiocaseinolytic assay were performed in 40 healthy women and 29 patients with various types of toxemia throughout pregnancy, labor and the puerperium. The results indicate that: 1. The urinary plasmin level in normal pregnancy increased significantly from the third trimester to the early puerperium. 2. In mild pre-eclampsia, a significant rise in urinary plasmin level from 26 weeks of gestation to the 4th day post-partum. 3. In severe pre-eclampsia, a progressive decrease in late pregnancy was found. After delivery, in the early puerperium, the urinary plasmin level of the patients with a rapid clinical was significantly higher than that of the patients with the sequelae of toxemia. Our study showed that serial assays of urinary plasmin activity can provide a reliable and sensitive index of severity, progression and natural history of toxemia of pregnancy.

Abruptio Placentae↗