[The pediatric hospital of the 90's. Needs of the population--demands on pediatrics].
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Biomedical subjects
Publications and source records attributed to H Ewerbeck.
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The most important task of the physician in the delivery room is the initial and continued assessment of the premature or mature newborn. The sequence of resuscitative efforts is determined by the respiratory and circulatory changes in the baby. The procedure is summarised in an action flow sheet. If spontaneous respiration is inadequate, artificial ventilation should be begun; if the heart rate remains below 80/min cardiac massage should be instituted. There are special indications for the intubation of the trachea and the tracheal suction. In some cases catecholamines and infusions are required. One must be certain that the necessary equipment is available and properly prepared.
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Serum C-reactive protein (CRP) is known to be produced by full-term infants and children in many diseases causing severe inflammation. We examined the usefulness of CRP as an early indicator of bacterial infection in premature newborn infants. CRP was obtained from 100 patients enrolled in a prospective study. All babies were suspected of having bacterial infection (meningitis-septicaemia) because of complications during pregnancy and/or symptoms suggestive of infection during the perinatal period. CRP was measured with the radial immunodiffusion technique. Examinations were done daily as long as elevated serum CRP levels were found. 100% (6/6) of our patients with culture-proven bacterial infections showed elevated CRP values within 24 h after the first clinical or laboratory signs suggesting sepsis. In 52.3% (11/21) of cases most probably suffering from infection, CRP rose within 72 h after the appearance of other symptoms. Even extremely immature infants were able to react with elevated CRP concentrations. Peak values of CRP were independent of birth weight. On the other hand, only 2.7% (2/73) of babies without findings of infection had slightly elevated amounts of CRP for a short time. Thus, serum CRP levels are a helpful parameter for the early diagnosis of severe bacterial infection in premature infants.
The lobes most commonly affected are the left upper and the right middle lobes. The classical sign of respiratory distress is mainly found within the first two months of life. In 14 infants the diagnosis was confirmed by microscopic examination, 13 were treated by surgery and 4 infants, who had associated serious malformations or complications, died. In most cases hypoplastic bronchial cartilage of the concerned bronchi was seen, in some cases a stenosis of the lobar bronchi. It is of great importance to establish the diagnosis as soon as possible. The lobectomy is recommended if the respiratory or cardial failure is worsening despite artificial ventilation.
The uncertain prognosis of premature newborn with an extremely low birth weight has so far resulted in uncertainty regarding the therapeutic measures to be taken, both with obstetricians and with paediatricians. However, the follow-up studies made up to now show that such infants do not have bad prospects. Prematurely born infants with a birth weight of 1000-1500 g are without any later handicaps with a quota of 85-90% provided they are given well-organized intensive-care treatment. Children between 750-1000 g birth weight are without psychomotor anomalies with an average incidence of 75-80%. However, the few available studies conducted on even more severely immature infants point towards a rapidly rising probability of physical disability if the birth weight is below 750 g or the duration of pregnancy less than 26 weeks. It seems that this denotes the present limit value of perinatal intensive-care medicine.
The fundamentally different approaches of modern science-based medicine and of those magic diagnostic and therapeutic procedures like iridiagnosis anthroposophical medicine, homeopathy, cell-therapy, neural-therapy, magnetic therapy and others, are analysed. Science-based medicine relies on the rules of the principle of causality, reproducibility, and predictability of its results, supported by its success. The dangers of modern medicine are its rationality and factualness which the doctor has to adapt individually to each patient. Otherwise he renders the patient susceptible to paramedical methods which make use of his suggestibility and need for comfort and consolation. Nothing is to be said against these methods as long as they are used as a psychotherapeutic vehicle, do no harm, and do not exploit the patient economically. If that would be the case, the patient must be protected against such quackery.
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