Congenital aneurysms of the muscular interventricular septum are rare. We report two brothers with this disease and their father, who had marked thinning of part of the muscular interventricular septum with paradoxical motion. These cases lend support to the idea that these aneurysms are the result of an inherited defect in the myocardium.

Adult↗

PubMedDate not supplied

Studies on the different mechanisms by which heparin and polysulphated xylan (PZ 68) inhibit blood coagulation in man.

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Blood Coagulation↗

PubMedDate not supplied

Triglycerides and blood glucose are the major coronary risk factors in elderly Swedish men. The study of men born in 1913.

In 1980 we examined 707 67-year-old men, 656 of whom had no previous myocardial infarction. During 8 years of follow-up, 70 (10.7%) of the 656 men developed a first myocardial infarction or died from coronary heart disease (CHD). The incidence of CHD increased 1.6-fold from the lowest to the highest quintile of cholesterol levels, 2.7-fold from the lowest to the highest quintile of triglyceride levels, and 2.2-fold among those with diabetes. Blood pressure, smoking habits, and two measurements of obesity (body mass index and waist circumference) were not significantly related to the incidence of CHD. In multivariate analysis, serum triglyceride levels and blood glucose concentration remained as significant risk factors for CHD. This may reflect that disturbances in glucose and triglyceride metabolism (as part of a metabolic syndrome?) are more important CHD risk factors in older than in younger men.

Aged↗

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The effects of the vacuum on vascular permeability of the middle ear.

Following local application of various degrees of negative pressure to the middle ear, the authors observed changes in vascular permeability in guinea pigs, using Majno's vascular labelling technique. Increased permeability and effusions were seen in all experimental middle ears. Any pressure below -5 mm of mercury induced middle ear effusions. Accordingly, a decrease in pressure developed in the middle ear cavity may cause transdation of serum drawn from the submucosal vessels, resulting in fluids in the middle ear of aero-otitis. In such a circumstance, mast cells which are easily influenced by atmospheric pressure may be involved in increasing vascular permeability.

Animals↗

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Neurotoxic effects of manganese: studies on cell cultures, tissue homogenates and intact animals.

This paper gives a short summary of some neurotoxic effects of manganese. Further, a model of toxicological action of manganese is discussed. Such a model should probably involve influences via redox reactions. In this study results revealed that the lipid peroxidation was reduced when neuroblastoma cells in culture were treated with manganese chloride. Additionally, the thiol content of proteins as well as non-protein thiols were reduced in the same experimental system. Due to the essential function of thiol groups in life processes, the observed drop in the amount of thiols must be of some importance for the toxicology of manganese. In relation to this, previously known physiological and biochemical effects of manganese are discussed.

Animals↗

PubMedDate not supplied

Deep vein thrombosis and pulmonary embolism in the general population. 'The Study of Men Born in 1913'.

BACKGROUND: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are common public health problems. Still, little is known about the epidemiology and the natural history of venous thromboembolism. METHODS: In the Study of Men Born in 1913, 855 men were followed up prospectively from the age of 50 years to the age of 80 years. Several cross-sectional samples, also of men born in 1913, were studied at the ages of 50, 54, 60, 67, 75, and 80 years. Objective methods were used to ascertain a diagnosis of DVT or PE, and all were confirmed by hospital records or autopsy reports. The follow-up rate in the longitudinal study was 98.2%. RESULTS: In the longitudinal study, the incidence of DVT was 182 per 100,000 observation-years. Corresponding incidence rates were 98 for nonfatal PE, 107 for fatal PE, and 387 for all thromboembolic events. The cumulative probability for a venous thromboembolic event at different ages was estimated to be 0.5% by the age of 50 years and 10.7% by the age of 80 years. In the cross-sectional studies, a history of confirmed venous thromboembolism was found in 0.5% of the men at age 50 years, 0.9% at age 54 years, 1.3% at age 60 years, 2.0% at age 67 years, 4.5% at age 75 years, and 3.8% at age 80 years. CONCLUSIONS: The results indicate a high incidence of DVT and PE in the general population. The incidence of thromboembolic events increases with age. The rate of fatal PE seems to be higher than estimated before, and PE constitutes almost 5% of all deaths during follow-up.

Age Distribution↗