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Biomedical subjects

H Eggers

Publications and source records attributed to H Eggers.

At least 37 records · Page 2Linked to original sources
PubMed1989

[East German percentile values for newborn infants--1985 relation of age, parity, body weight and height of the mother and the birth weight of newborn infants].

Based on an analysis of very comprehensive data material multidimensional investigations on connections between age, parity, weight and height of mothers and birth weight of infants have been made. Maternal height as well as maternal weight have a considerable influence on birth weight of infants. At the same maternal height infant birth weight will rise in connection with the rise of maternal weight. Maternal age, parity and weight are correlated variables. The older a woman, the higher on average is not only her parity but at the same her weight, too. The rise of maternal weight per year in the statistic mean amounts to 401 g. Moreover, at the same age like primiparae second and subsequent parae are of higher weights so that partly maternal weight contains indirectly not only maternal age but also maternal parity. The following range of the influencing factors maternal height, weight, parity and age on birth weight can be given: 1. Height and weight as relatively equivalent factors, 2. parity and 3. age.

Adolescent↗
PubMed1989

[New percentile values for birth weight, body length, head and breast circumference of newborn infants in East Germany].

Somatometric data of 51,570 newborns (singles) delivered between the 28th and 42th week of gestation from different, representative areas of the G.D.R., concerning birth weight, body length, head and breast circumference are presented as tables and percentile curves separately for either sex. The values are recommended as reference values for the assessment of fetal development related to gestational age in the G.D.R.

Anthropometry↗
PubMed1989

[Neonatal percentile values for East Germany--1985. 3. On the correlation of body height and weight of the mother in a two-dimensional classification of newborn infants according to birth weight and gestational age].

There were published percentiles of birthweight in relation to bodyheight of the mother as well as in relation to bodyweight and parity, bodyheight and bodyweight of the mother for term range 37th to 41st week of pregnancy. They were calculated through median quantities. The dates again derive from the investigation of 51,570 single births in elected regions of GDR in 1984 and 1985. The length of pregnancy was stated in full weeks. It was determined on the base of three parameters (by Naegele method, by sonography, and by neonatal maturity judgment). Selected percentiles of birthweight regarding the above influencing factors, distributed into sex, were summarized for use in practice.

Birth Weight↗
PubMed1988

[Percentiles of newborns in the DDR--1985. 1. Percentiles of birth weight and birth height].

Body measures of newborn infants and their parents were comprehended and statistically revised in 30 hospitals of German Democratic Republic in 1984-1985. There were records of 52,570 single livebirths without birth defects of women living in the GDR (51.3 per cent boys and 48.7 per cent girls). Percentiles were calculated and demonstrated in tables and figures. Base of calculation of percentiles was a pregnancy week final diagnosis. It was determined by the physician resulting from three investigations of pregnancy week (methods Naegele; ultrasound; maturity index). Percentiles of birthweight and birthlength of newborn infants in GDR in 1984-1985 are lower than those in 1973-1974. Causes are discussed. Our results are compared with two Middle European curves and with Lubchenco curve (1963).

Body Height↗
PubMed1988

Effect of food intake on the relative bioavailability of moclobemide (Ro 11-1163).

Twelve healthy adult volunteers received a single 100-mg tablet of moclobemide in an open-label crossover study designed to determine the influence of food on moclobemide absorption. Moclobemide was administered 30 min after a standard breakfast as well as under fasting conditions. Moclobemide absorption was rapid in the absence of food. Bioavailability parameters obtained when drug was taken 30 min after the meal suggested that the rate of absorption was slightly decreased in the presence of food (mean Tmax 0.71 h vs. 1.14 h), while the extent of absorption of moclobemide given with food was unaltered. The decreased absorption rate in the presence of food is not expected to be of clinical significance.

Adult↗
PubMed1987

Determination of the new monoamine oxidase inhibitor moclobemide and three of its metabolites in biological fluids by high-performance liquid chromatography.

A sensitive high-performance liquid chromatographic method has been developed for the determination of moclobemide and three of its metabolites in plasma and urine. The four substances and the internal standard were extracted from basified plasma (pH 11) with dichloromethane, with recoveries of generally more than 70%. A column packed with 5-microns Spherisorb hexyl phase and an eluent consisting of acetonitrile and aqueous phosphate buffer 30:320 (v/v) with a pH of 3.9 were found most suitable for the chromatographic separation of the four compounds of interest. Non-ideal interactions of the basic compounds and the N-oxide metabolite occurred with many other reversed-phase materials, as indicated by broad and tailing peaks. Limits of quantitation for moclobemide and its three metabolites in the range 20-30 ng/ml and a good intra-assay reproducibility ranging between 2 and 5% for concentrations over 100 ng/ml could be achieved for plasma, which increased to ca. 8-10% at a concentration of 50 ng/ml.

Benzamides↗
PubMed1987

Disposition kinetics of moclobemide, a monoamine oxidase-A enzyme inhibitor: single and multiple dosing in normal subjects.

The absorption and disposition kinetics of moclobemide (Ro 11-1163), a new reversible and preferential monoamine oxidase-A enzyme inhibitor, were examined in 12 normal male subjects. An intravenous infusion was administered before and after a 15-day multiple oral dosing regimen (100 mg t.i.d.). Plasma concentration-time data were obtained after each intravenous infusion, after the first oral dose, during two dosing intervals at steady state, and before the second daily dose on several days. The disposition values (percent coefficient of variation in parentheses) after the first and second intravenous infusions, respectively, were: clearance, 39.4 (15%) and 29.1 (12%) L/hr; elimination half-life, 1.60 (15%) and 2.00 (18%) hours; and volume of distribution at steady state, 84.3 (11%) and 80.7 (15%) L. The absolute oral bioavailability increased from 0.56 after the first oral dose to 0.86 and 0.90 after the first and second weeks of administration, respectively. The reduced metabolic, presumably hepatic, clearance may be the result of self-inhibition or metabolite inhibition of moclobemide clearance.

Administration, Oral↗
PubMed1985

Computer-assisted spectral electroretinography in vitrectomy patients.

Computer-assisted spectral electroretinography (CASE), using full field stimulation in the presence of a rod saturating background light, has been found to be a useful means of evaluating retinal function in patients with vitreal opacities. By this means, cone electroretinograms (ERGs) to white as well as spectrally selective stimuli could easily be detected in 22 of 24 eyes with vitreal opacities obscuring any view of the fundus and with minimal or no detectable ERGs to standard single flash stimuli. The responses to spectral stimuli in the presence of a rod saturating background light provides a means of estimating the optical density of the opacity. The results indicate that most patients undergoing vitrectomy for such opacities have considerable superimposed retinal damage and that the opacities themselves are seldom sufficiently dense to decrease the ERG to any great extent. Five eyes studied before and after vitrectomy indicate that successful vitrectomy has no effect on the ERG. The results suggest that CASE may be a useful substitute to the bright flash ERG for evaluating global retinal function behind an opaque media.

Adolescent↗
PubMed1985

Transplantation of cultured human retinal epithelium to Bruch's membrane of the owl monkey's eye.

Human retinal epithelial cells dividing in culture have been radiolabelled with tritiated thymidine and subsequently transplanted and identified on Bruch's membrane of owl monkey by autoradiography. Such cells have been followed from 2 hours to 7 days after transplantation. The transplant cells reattach within 2 hours to the basement membrane left on Bruch's membrane after the host epithelial cells have been removed by suction after trypsinization. Within 6 to 24 hours they form a layer on Bruch's membrane with junctional complexes between cells and an apical-basal polarity characteristic of such cells in culture or after retinal detachment. After 2 to 7 days multilayers form by continued mitosis but no transplant cells invade the choroid as long as Bruch membrane is intact. Within this time macrophages begin to appear in the choriocapillaris under the transplant. These cells migrate through Bruch's membrane and between the transplant cells but have not been seen phagocytizing transplant cells. Reattachment of the neural retina to the transplant layer has not been attempted but seems technically possible.

Animals↗
PubMed1984

Hering's opponent colour channels do not exist in the primate retinogeniculate pathway.

We have used pure hue contrast stimuli to examine the responses of single primate retinal ganglion cells. Only one subset of these cells, those excited by the short wave sensitive cones and inhibited by the other cones, i.e. the blue-on/yellow-off variety, can distinguish white/yellow contrast. This implies that the paired opponent channels of Hering 's colour vision theory do not exist in the retinogeniculate pathway.

Animals↗
PubMed1984

F-Met-Leu-Phe and echo 9 virus interaction with human granulocytes. Changes of cell membrane structure.

Biophysical and biochemical methods were applied for investigation of cell membrane properties of human polymorphonuclear leukocytes (PMNs) exposed to the chemotactic peptide N-formylmethionyl-leucylphenylalanine (f-Met-Leu-Phe) and echovirus type 9, strain A, Barty. Steady-state fluorescence depolarization with diphenylhexatriene demonstrated no gross changes of the total membrane fluidity under the different experimental conditions. However, by means of the monomer-excimer technique with pyrenedecanoic acid (PDA), significant changes of the local membrane structure were detected for both agents. As demonstrated by a higher excimer ratio, the membrane area available for the PDA molecules was restricted by f-Met-Leu-Phe. This effect was dependent on the dose and on the time of interaction of the chemotactic peptide. These experimental findings were explained by the formation of functional receptor units ("activated membrane"). Echo 9 virus exhibited the opposite effect, characterized by a higher ratio of monomers, which also depended on the viral dose and the time of virus-PMN interaction. These virus-induced findings were explained by the dissolution of functional receptor units. Consecutive exposure of the PMNs to f-Met-Leu-Phe and echovirus, or vice versa, demonstrated a virus-predominant effect on the membrane structures.

Cell Membrane↗
PubMed1983

Responses of primate retinal ganglion cells to moving spectral contrast.

A moving border formed by color contrast across which brightness contrast can be independently controlled was used to examine responses of ganglion cells in monkey retina. We used two forms of color contrasts, white/yellow and red/green. Three classes of ganglion cells were examined: blue/yellow opponent, red/green opponent and non-color opponent on-center phasic cells. Blue/yellow opponent cells respond strongly to white/yellow contrast at all brightness gradients, responding better to a white/yellow border at minimum brightness contrast than to a white/black border at maximum brightness contrast. These cells respond before and reach their maximum response long after the border has crossed the receptive field center. Red/green opponent and phasic non-opponent cells do not detect white/yellow borders at minimum brightness contrast; at sufficient brightness contrast phasic and some red/green opponent cells detect this border responding maximally as the border crosses their receptive field center. Red/green opponent and non-opponent phasic on-center cells respond to red/green contrast at both maximum and minimum brightness contrast. The former are excited by only one side, the latter by either side of the red/green contrast entering their receptive field. Phasic on-center cells have a maintained excitatory rod signal which is suppressed when a detectable border enters their field. The results suggest that the blue/yellow opponent system plays a major role in distinguishing white/yellow borders and has a poorer spatial resolution than the red/green one, that phasic ganglion cells receive a rod and a red/green but not a blue/yellow opponent input, and that this blue/yellow system has a retinal pathway which does not obviously influence rods or other cones.

Action Potentials↗
PubMed1983

[Development of morbidity in hemolytic disease of the newborn after the introduction of immune prophylaxis at the Rostock blood exchange center from 1970 to 1980].

The development of morbus haemolyticus neonatorum morbidity is demonstrated by referring to the example of the "exchange centre" in Rostock after using anti-D-immunprophylaxis for more than 10 years. The level achieved is compared with findings in international studies. The main cause for rest morbidity consists in omitting indicated immunoprophylaxis. Further progress in reducing the morbidity of morbus haemolyticus neonatorum can only be achieved by keeping physicians informed about the deleterious consequences of anti-D-immunisation having occurred.

Erythroblastosis, Fetal↗