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Biomedical subjects

H Egeblad

Publications and source records attributed to H Egeblad.

At least 55 records · Page 3Linked to original sources
PubMed1990

Left ventricular function during balloon dilatation of the aortic valve in elderly patients: a blind study of echocardiograms.

Subcostal echocardiography of the left ventricle was continuously recorded during balloon dilatation of the aortic valve in ten consecutive elderly patients. Left ventricular wall motion decreased gradually during a minute of maintained complete balloon inflation. Blind analysis of M mode echocardiograms showed a significant reduction in fractional shortening. Deflation of the balloon resulted in global left ventricular hyperkinesia. There was a transient overshoot in fractional shortening, wall thickness, and blood pressure approximately 40 s after deflation of the balloon. The myocardial reaction was similar to that known to occur regionally with brief coronary artery obstruction, whereas the timing of the events seemed to be dissociated from the timing of changes in left ventricular load. Thus it is likely that the left ventricular response during valve dilatation reflects not only changes in load but also an ischaemia-reperfusion effect on the myocardium. The systolic thickening of the hypertrophied interventricular septum was slightly reduced after balloon dilatation. This finding might be a result of repeated episodes of ischaemia and reperfusion. However, the potential for myocardial injury seemed to be unimportant clinically.

Aged↗
PubMed1989

Thromboembolism in patients with advanced mitral valve prolapse.

Thromboembolism in mitral valve prolapse (MVP) has been suggested to occur in relation to valvular cul-de-sac recesses and endothelial wear-and-tear denudations. Such pathology would be suspected to be prominent in advanced cases of MVP necessitating open-heart operation. We therefore analysed the prevalence of perivalvular thrombi and episodes of systemic arterial embolism (SE) prior to operation in 21 consecutive patients with MVP and severe valve regurgitation. No perivalvular or left atrial thrombi were found during open-heart surgery, but three of the patients (14%, 3-36% with 95% confidence limits) experienced SE, in one case despite long-term anticoagulation. All cases of SE took place less than 3 months before operation. The results indicate that persistent thrombi are rare in MVP and severe valve regurgitation. However, such patients run a substantial risk of SE when they reach a clinical and haemodynamic stage that makes valve surgery mandatory.

Female↗
PubMed1987

Mitral annulus calcification and embolism.

Of 388 patients consecutively referred to echocardiography, 49 were suspected of having a cardiac source of systemic arterial embolism (SE). Mitral annulus calcification (MAC) was revealed in 27% of the patients with SE and in 8% of the remaining patients (p less than 0.05). The group of patients with SE were slightly older (median age 67 years) and included more female patients (47%) compared to the group without SE (62 years, p less than 0.05; 40% female patients, p greater than 0.05). However, the small differences in age and sex distribution did not explain satisfactorily the considerably increased prevalence of MAC in the group of patients with SE. Our preliminary data indicated that thromboembolism caused by left atrial dilatation and atrial fibrillation might be the most important cause of the condition in patients with MAC and SE. However, the significance of the possible mechanisms of embolism in patients with MAC and the incidence of the complication should be further clarified before therapy and prophylaxis can be suggested.

Adult↗