Search PubMed⌕ Search

Biomedical subjects

H Ebel

Publications and source records attributed to H Ebel.

133 records · Page 8Linked to original sources
PubMedDate not supplied

Long-term neuropsychological outcome after severe head injury with good recovery.

The quality of outcome after severe closed head injury has become of increasing concern to neurosurgeons. The assessment of residual deficits in patients who have recovered from closed head injury can be very difficult. Many patients are classified as having a good recovery according to the Glasgow Outcome Scale (GOS), but this may be insufficiently focused or sensitive to demonstrate mental deficits objectively. We investigated 33 patients with severe closed head injury who subsequently were diagnosed as having made a good recovery according to the GOS. The severity of the injury was determined by the Glasgow Coma Scale (GCS) and by the presence of a midline shift in the preoperative CT scans. There was a minimal interval of 15 months (means = 1080.5 days, SD = 491 days) between injury and time of neuropsychological testing. Their performance was compared with that of 15 orthopaedic cases. Residual neuropsychological deficits can be demonstrated on the majority of measures in a group of patients who have achieved good recovery on the GOS. Midline shift in preoperative CT scans is not of prognostic value for long-lasting neuropsychological deficits.

Activities of Daily Living↗
PubMedDate not supplied

Inhibition of (Na+K+)-ATPase and cation transport by an antibody against renal plasma membranes.

An antibody was raised in rabbits against NaI extracted plasma membranes of rat kidney. The antibody inhibited (Na+K+)-ATPase of basolateral membranes and of rat erythrocyte ghosts. Also K+-stimulated pNPase was inhibited. No effect on Mg-ATPase and basal pNPase activity was registered. Kinetic experiments with Na+,K+ and Mg-ATP showed a noncompetitive inhibition of (Na+K+)-ATPase by the antibody. Hill constants were unchanged. In renal epithelial cell cultures as well as in intact rat erythrocytes ouabain sensitive 22Na-efflux and 42K influx was inhibited by the antibody. It is concluded that outward facing Na+K+-ATPase is immunogenic. The antibody can be raised when the antigen is adequately disintegrated to open otherwise hidden antigenic sites.

Animals↗