Search PubMed⌕ Search

Biomedical subjects

H Ebel

Publications and source records attributed to H Ebel.

At least 91 records · Page 5Linked to original sources
PubMed1990

Influence of computer-modulated profile haemodialysis on cardiac arrhythmias.

To reduce hamodialysis-induced ventricular arrhythmias, each of 15 patients (age 66.9 +/- 6.2 years) with end-stage renal disease and cardiac irregularities was treated subsequently with four different computer-modulated bicarbonate haemodialysis profiles (A-D) for 2 weeks respectively: (A) constant UF, dialysate Na (138 mmol/l) and K (2 mmol/l); (B) decreasing UF, otherwise as (A); (C) decreasing UF and Na (starting with 10% higher than serum Na), otherwise as (A); (D) decreasing UF and Na, adapted K to achieve a maximal reduction of serum K of only 15%/h. Cardiac monitoring was done by 11 h ECG. Only in haemodialysis profile D a distinct reduction of ventricular extrasystoles during and after haemodialysis was obtained. It was accompanied by an improvement in the Lown classification. In addition, a weak but highly predictive correlation between the number of ventricular extrasystoles in the last hour of dialysis and the difference between pre- and post-dialysis potassium concentration in the serum could be established (r = 0.37; P less than 0.004). Computer-modulated potassium profile haemodialysis is a useful tool to reduce the number and severity of ventricular extrasystoles.

Aged↗
PubMed1989

A rapid laser immunonephelometric assay for serum amyloid A (SAA) and its application to the diagnosis of kidney allograft rejection.

We set up a laser nephelometric assay for the quantitation of serum amyloid A (SAA) in human plasma. Therefore monospecific antibodies were raised in sheep and used in parallel to measure SAA concentrations by nephelometry and also by radial immunodiffusion, an assay usually applied for determination of SAA. The nephelometric method is precise, simple and unlike radial immunodiffusion results are obtained within an hour. The antigen concentrations determined both by laser nephelometry and radial immunodiffusion correlated highly (r = 0.98). As plasma SAA concentrations were reported to be a possible marker of kidney allograft rejection, the assay was applied to measure SAA concentrations in patients after kidney transplantation. Data were compared with clinical and other biochemical parameters. The period after kidney transplantation is reported for two cases, where SAA plasma concentrations were helpful in diagnosing allograft rejection. The rapid availability of the SAA plasma concentrations by nephelometry makes them a possible additional tool to decide quickly upon antirejection therapy.

Graft Rejection↗
PubMed1989

Basic symptoms in schizophrenic and affective psychoses.

The study compares schizophrenic and affective psychoses with regard to basic symptoms. 30 patients in schizophrenic pre-, intra-, and postpsychotic basic stages and 30 patients in endogenous-depressive phases were examined according to the Bonn Scale for the Assessment of Basic Symptoms. The most important result is that certain cognitive basic symptoms and cenesthesias which are decisive for the development of florid productive-psychotic phenomena are found more frequently in the group of schizophrenias.

Adult↗
PubMed1987

[99mTc tin colloid scintigraphy in the diagnosis of acute rejection reactions in kidney transplants].

Quantitative measurements of 99MTc-tin colloid uptake in renal transplants permits differentiation of acute rejection from other causes of deteriorating renal function, such as acute tubular necrosis, cyclosporin A nephrotoxicity or chronic rejection. 144 99mTc-tin colloid scintigrams were performed on 71 renal transplants; the results were compared with clinical, biochemical and histological findings. Sensitivity of colloid scintigraphy is 97.4% and specificity is 80%. Compared with other isotope methods, this has the advantage that it does not depend on comparison with repeated examinations.

Cyclosporins↗
PubMed1985

Anion sensitive ATPase in human cornea.

In human cornea an anion sensitive ATPase is present. The highest specific activity was found in the endothelium, whereas the epithelium contained the highest total activity. The enzyme was stimulated by bicarbonate and sulfite and inhibited by thiocyanate. the majority of the enzyme was localized in the mitochondria but some activity was also detected in the plasma membranes. Atractyloside inhibited only the mitochondrial anion ATPase.

Adenosine Triphosphatases↗
PubMed1983

Role of magnesium in cardiac disease.

Some aspects of the pathogenesis of cardiac disease are reviewed in the light of current knowledge of the physiological and biochemical actions of magnesium (Mg2+) on heart function. Several authors have reported a reduction of the human myocardial Mg2+ content in areas with (Mg2+ poor) soft water, without a significant alteration of Mg2+ in serum or skeletal muscle. In human during myocardial infarction, there is a reduction of Mg2+ content even in noninfarcted areas of the myocardium, followed by a transient reduction of serum Mg2+ concentration. These effects are explained by the action of catecholamines on the myocardial cells, resulting in a loss of Mg2+ accompanied by a catecholamine-induced urinary Mg2+ loss and/or increased lipolysis which binds Mg2+ as Mg2+ soaps in the adipocytes. As a consequence serum Mg2+ may be decreased. A reduced serum Mg2+ concentration may enhance the action of catecholamines on the heart muscle as well as the action of vasopressive hormones, thus provoking contraction of coronary artery smooth muscle cells and favouring the development of arrhythmia.

Arrhythmias, Cardiac↗
PubMed1982

GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets.

The potent alpha 2-adrenergic receptor antagonist 3H-yohimbine was used to characterize alpha-adrenergic receptors in human platelet membranes. Binding of 3H-yohimbine was at 25 degrees rapid (t 1/2 = 3 min) readily reversible (t 1/2 = 5.5 min), saturable with 221 +/- 38.9 fmoles bound/mg protein (N = 10) and of high affinity (KD = 1.97 nM). Inhibition of binding by alpha-adrenergic antagonists showed monophasic displacement curves with Hill-coefficients of approximately 1.0. The rank order of potency was: rauwolscine greater than or equal to yohimbine greater than phentolamine greater than phenoxybenzamine greater than AR-C 239 greater than or equal to corynanthine greater than prazosin, indicating that the alpha-adrenergic receptor in human platelets is of the alpha 2-subtype. On the contrary, agonist (clonidine, guanfacine, alpha-methyl-noradrenaline, noradrenaline and adrenaline) displacement curves were shallow with Hill-coefficients of approximately 0.7. Non-linear regression analysis showed that agonists bind to two affinity states of the alpha 2-adrenergic receptor, a high and a low affinity state. In the presence of GTP (10(-4) M) agonist concentration-inhibition curves were shifted to the right to lower affinities and Hill-coefficients increased up to 1.0 K1-values for inhibition of binding in the presence of GTP were in the same range as those for low affinity state in the absence of GTP. It is concluded that GTP regulates binding of alpha 2-adrenergic agonists at the human alpha 2-adrenergic receptor.

Adrenergic alpha-Agonists↗
PubMed1980

Magnesium metabolism: a review.

The main literature concerning the physiology and biochemistry as well as the pathophysiology and pathobiochemistry of magnesium is reviewed, including: Distribution and physico-chemical state of magnesium in the extracellular and intracellular fluid as well as in the subcellular organelles (membranes, mitochondria, microsomes, ribosomes). Intestinal resorption, transport across membranes and excretion by the kidney. Hormonal regulation of magnesium distribution and its clinical disturbances. Biochemical mechanism and the clinical effects of hypo- and hypermagnesemia.

Adrenal Cortex Hormones↗