A prospective, randomized and double-blinded trial of the comparative effects of delta-9-tetrahydrocannabinol (THC) and haloperidol (H) was begun in February 1980. Patients were randomized to initially receive either THC or haloperidol with cross-over to the other agent after two courses. All patients evaluated efficacy and toxicity of each agent and those patients completing the study expressed a preference for either THC or haloperidol. All patients are receiving chemotherapeutic agents known to induce severe vomiting (cis-platinum, nitrogen mustard, or doxorubicin) or have a history or retching with chemotherapy. Fifty-two patients are evaluable as of October, 1980. THC and haloperidol were equally effective in controlling nausea and vomiting as judged by number of vomiting episodes, patient evaluation of efficacy, and patient preference. About 10% of patients had complete control of vomiting and a third had less than five episodes. Patients failing one of the antiemetics had good control with the other about half the time. Toxicities from THC were less well tolerated than those from haloperidol, but most patients had no serious side effects. Nonoverlapping toxicities and efficacy raise the possibility that a combination of the agents might be worthwhile.

Adult↗

PubMedDate not supplied

A controlled trial of the effect of calmic 131A in the treatment of transient cerebral ischaemic attacks.

Explore the source record for details and available documents.

Adult↗

PubMedDate not supplied

Multi-technique comparison of source and primary transfer soil samples: an experimental investigation by D Croft and K Pye. A comment.

The Croft and Pye paper has a story to tell about the differentiation capabilities of four analytical techniques. It is not however, the whole story. This may be due in part to the lack of reproducibility in the generation of results, and also in the effort to match soil samples and thus infer that the results provide stronger conclusions than is possible to make with this sort of analysis. More research must be done to establish in what instances these techniques and others provide reliable, reproducible, representative and accurate results, and in what capacity such results can be presented. As they stand, the results from this paper should be treated with great caution and not extrapolated to any other forensic case work until greater reliability of these and other techniques has been established.

Comment↗